ID	Title	Country	Ctl	MA	Type	Drugs	Primary Endpoint	Population	
<a href="https://ClinicalTrials.gov/show/NCT04319900">NCT04319900</a>	Clinical Trial of Favipiravir Tablets Combine With Chloroquine Phosphate in the Treatment of Novel Coronavirus Pneumonia	China	Y	Y	Drug Repurposing	Favipiravir, Chloroquine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04252885">NCT04252885</a>	The Efficacy of Lopinavir Plus Ritonavir and Arbidol Against Novel Coronavirus Infection	China	Y	Y	Drug Repurposing	Lopinavir/ritonavir, Umifenovir	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04282902">NCT04282902</a>	A Study to Evaluate the Efficacy and Safety of Pirfenidone With Novel Coronavirus Infection	China	Y	N	Drug Repurposing	Pirfenidone	Efficacy - Oxygen parameters	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04329520">NCT04329520</a>	EPICOS Clinical Trial for the Prevention of Infection in Healthcare Personnel	Spain	Y	Y	Drug Repurposing	Emtricitabine/tenofovir, Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001224-33/DE">2020-001224-33</a>	Randomized controlled trial of hydroxychloroquine versus placebo for the treatment of adult patients with acute coronavirus disease 2019 &ndash; COVID-19	Germany	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04343677">NCT04343677</a>	Military COVID-19 Hydroxychloroquine Pre-exposure and Post-exposure Prophylaxis Study	United States	Y	Y	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001591-15/NL">2020-001591-15</a>	Reducing hospital admission of elderly in SARS-CoV-2 pandemic via the induction of trained immunity by bacillus Calmette-Gu&eacute;rin vaccination, a randomized controlled trial. (COVID-19)	Netherlands	Y	N	Drug Repurposing	BCG Vaccine	Efficacy - Other efficacy	Other	
<a href="https://ClinicalTrials.gov/show/NCT04380948">NCT04380948</a>	A Pilot Study Evaluating the Effect of NT-I7, a Long Acting Interleukin-7, to Enhance Immune Clearance of SARS-CoV-2 (COVID-19)	United States	Y	N	Shelved drug or NME	NT-17	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04308668">NCT04308668</a>	Post-exposure Prophylaxis / Preemptive Therapy for SARS-Coronavirus-2	United States	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	General population	
<a href="https://ClinicalTrials.gov/show/NCT04276987">NCT04276987</a>	A Pilot Clinical Study on Inhalation of Mesenchymal Stem Cells Exosomes Treating Severe Novel Coronavirus Pneumonia	China	N	N	Cell/Blood based	ND:Stem cells	Safety	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001684-89/GB">2020-001684-89</a>	CATALYST - A randomised phase II proof of principle multi-arm multi-stage trial designed to guide the selection of interventions for phase III trials in hospitalised patients with COVID-19 infection.	United Kingdom	Y	N	Drug Repurposing	Gemtuzumab ozogamicin	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04380961">NCT04380961</a>	A Study to Evaluate the Efficacy and Safety of Sirukumab in Confirmed Severe or Critical Confirmed Coronavirus Disease (COVID)-19	United States	Y	N	Shelved drug or NME	Sirukumab	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04328467">NCT04328467</a>	Pre-exposure Prophylaxis for SARS-Coronavirus-2	United States	Y	Y	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	General population	
<a href="https://ClinicalTrials.gov/show/NCT04333251">NCT04333251</a>	Study Testing Convalescent Plasma vs Best Supportive Care	United States	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04380701">NCT04380701</a>	A Trial Investigating the Safety and Effects of Four BNT162 Vaccines Against COVID-2019 in Healthy Adults	Germany	N	N	Vaccine	ND:BNT162 vaccine	Safety	General population	
<a href="https://ClinicalTrials.gov/show/NCT04367168">NCT04367168</a>	Colchicine Twice Daily During 10 Days as an Option for the Treatment of Symptoms Induced by Inflammation in Patients With Mild and Severe Coronavirus Disease	Mexico	Y	N	Drug Repurposing	Colchicine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04316377">NCT04316377</a>	Norwegian Coronavirus Disease 2019 Study	Norway	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04276688">NCT04276688</a>	Lopinavir/ Ritonavir, Ribavirin and IFN-beta Combination for nCoV Treatment	Hong Kong	Y	Y	Drug Repurposing	Ribavirin, Interferon beta-1b	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT03852537">NCT03852537</a>	Steroid Dosing by bioMARker Guided Titration in Critically Ill Patients With Pneumonia	United States	Y	N	Drug Repurposing	Methylprednisolone	Other	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04404192">NCT04404192</a>	PH94B in the Treatment of Adjustment Disorder With Anxiety	United States	N	N	Shelved drug or NME	PH94B	Efficacy - Other efficacy	General population	
<a href="https://ClinicalTrials.gov/show/NCT04356833">NCT04356833</a>	Nebulised Rt-PA for ARDS Due to COVID-19	United Kingdom	N	N	Shelved drug or NME	Nebulised Rt-PA	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04392219">NCT04392219</a>	COVID-19 First In Human Study to Evaluate Safety, Tolerability, and Pharmacokinetics of EIDD-2801 in Healthy Volunteers	United States	Y	N	Shelved drug or NME	EIDD-2801	Safety	General population	
<a href="https://ClinicalTrials.gov/show/NCT04373707">NCT04373707</a>	Weight-Adjusted vs Fixed Low Doses of Low Molecular Weight Heparin For Venous Thromboembolism Prevention in COVID-19	France	Y	N	Drug Repurposing	Enoxaparin	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT03648372">NCT03648372</a>	A Study to Evaluate the Safety, Tolerability and Pharmacokinetics (PK) of TAK-981 in Adult Participants With Advanced or Metastatic Solid Tumors or Relapsed/Refractory Hematologic Malignancies and in a Subset With Coronavirus Disease 2019 (COVID-19)	United States	N	N	Shelved drug or NME	TAK-981	Safety	Other	
<a href="https://ClinicalTrials.gov/show/NCT04393415">NCT04393415</a>	Using PRP and Cord Blood in Treatment of Covid -19	Egypt	Y	N	Cell/Blood based	ND:Stem cells	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04264533">NCT04264533</a>	Vitamin C Infusion for the Treatment of Severe 2019-nCoV Infected Pneumonia	China	Y	N	Drug Repurposing	Ascorbic acid	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04323527">NCT04323527</a>	Chloroquine Diphosphate for the Treatment of Severe Acute Respiratory Syndrome Secondary to SARS-CoV2	Brazil	Y	N	Drug Repurposing	Chloroquine	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04322682">NCT04322682</a>	Colchicine Coronavirus SARS-CoV2 Trial (COLCORONA)	Canada	Y	N	Drug Repurposing	Colchicine	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04385836">NCT04385836</a>	Trial of Alpha One Antitrypsin Inhalation in Treating Patient With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)	Saudi Arabia	Y	N	Cell/Blood based	ND:Alpha-1 antitrypsin	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04275245">NCT04275245</a>	Clinical Study of Anti-CD147 Humanized Meplazumab for Injection to Treat With 2019-nCoV Pneumonia	China	N	N	Shelved drug or NME	Meplazumab	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04341727">NCT04341727</a>	Hydroxychloroquine,Hydroxychloroquine,Azithromycin in the Treatment of SARS CoV-2 Infection	United States	Y	Y	Drug Repurposing	Hydroxychloroquine, Azithromycin, Chloroquine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04342728">NCT04342728</a>	Coronavirus 2019 (COVID-19)- Using Ascorbic Acid and Zinc Supplementation	United States	Y	N	Drug Repurposing, Other	Ascorbic Acid, ND:Zinc Gluconate	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04404634">NCT04404634</a>	Convalescent Plasma To Limit COVID-19 Associated Complications	United States	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04347031">NCT04347031</a>	A Study of the Effectiveness of an Off Label Mefloquine Use for the Treatment of Patients With COVID19	Russian Federation	Y	Y	Drug Repurposing	Mefloquine, Hydroxychloroquine, Azithromycin, Tocilizumab	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04390152">NCT04390152</a>	Safety and Efficacy of Intravenous Wharton's Jelly Derived Mesenchymal Stem Cells in Acute Respiratory Distress Syndrome Due to COVID 19	Colombia	Y	N	Cell/Blood based	ND:Stem cells	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04348370">NCT04348370</a>	BCG Vaccine for Health Care Workers as Defense Against COVID 19	United States	Y	N	Vaccine	BCG Vaccine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04343729">NCT04343729</a>	Methylprednisolone in the Treatment of Patients With Signs of Severe Acute Respiratory Syndrome in Covid-19	Brazil	Y	N	Drug Repurposing	Methylprednisolone	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04323800">NCT04323800</a>	Convalescent Plasma to Stem Coronavirus (CSSC-001)	United States	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - WHO scale	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04376034">NCT04376034</a>	Convalescent Plasma Collection and Treatment in Pediatrics and Adults	United States	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04269525">NCT04269525</a>	Umbilical Cord(UC)-Derived Mesenchymal Stem Cells(MSCs) Treatment for the 2019-novel Coronavirus(nCOV) Pneumonia	China	N	N	Cell/Blood based	ND:Stem cells	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04261907">NCT04261907</a>	Evaluating and Comparing the Safety and Efficiency of ASC09/Ritonavir and Lopinavir/Ritonavir for Novel Coronavirus Infection	China	Y	N	Drug Repurposing, Shelved drug or NME	ASC09/ritonavir	Efficacy - Oxygen parameters	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04340557">NCT04340557</a>	Do Angiotensin Receptor Blockers Mitigate Progression to Acute Respiratory Distress Syndrome With SARS-CoV-2 Infection	United States	Y	N	Drug Repurposing	Losartan	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04323592">NCT04323592</a>	Efficacy of Methylprednisolone for Patients With COVID-19 Severe Acute Respiratory Syndrome	Italy	N	N	Drug Repurposing	Methylprednisolone	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04345289">NCT04345289</a>	Efficacy and Safety of Novel Treatment Options for Adults With COVID-19 Pneumonia	Denmark	Y	Y	Drug Repurposing, Cell/Blood based	ND:Convalescent plasma, Sarilumab, Baricitinib, Hydroxychloroquine	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04353037">NCT04353037</a>	PATCH 2&3:Prevention & Treatment of COVID-19 (Severe Acute Respiratory Syndrome Coronavirus 2) With Hydroxychloroquine	United States	Y	Y	Drug Repurposing	Hydroxychloroquine	Efficacy - Other efficacy	Exposed individuals (family members, HCP), Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04280224">NCT04280224</a>	NK Cells Treatment for COVID-19	China	Y	N	Cell/Blood based	ND:T-cells	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04388826">NCT04388826</a>	COVID-19 Treatment of Severe Acute Respiratory Syndrome With Veru-111	United States	Y	N	Shelved drug or NME	Veru-111	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04326426">NCT04326426</a>	ODYSSEY: A Study to Investigate the Efficacy of Tradipitant in Treating Severe or Critical COVID-19 Infection	United States	Y	N	Shelved drug or NME	Tradipitant	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04299152">NCT04299152</a>	Stem Cell Educator Therapy Treat the Viral Inflammation in COVID-19	China	Y	N	Cell/Blood based	ND:Stem cells	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04306393">NCT04306393</a>	Nitric Oxide Gas Inhalation in Severe Acute Respiratory Syndrome in COVID-19	United States	Y	N	Drug Repurposing	Nitric oxide	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04361552">NCT04361552</a>	Tocilizumab for the Treatment of Cytokine Release Syndrome in Patients With COVID-19 (SARS-CoV-2 Infection)	United States	Y	N	Drug Repurposing	Tocilizumab	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04322773">NCT04322773</a>	Anti-il6 Treatment of Serious COVID-19 Disease With Threatening Respiratory Failure	Denmark	Y	Y	Drug Repurposing	Tocilizumab, Sarilumab	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04336410">NCT04336410</a>	Safety, Tolerability and Immunogenicity of INO-4800 for COVID-19 in Healthy Volunteers	United States	N	N	Vaccine	INO-4800	Safety	General population	
<a href="https://ClinicalTrials.gov/show/NCT04338802">NCT04338802</a>	Efficacy and Safety of Nintedanib in the Treatment of Pulmonary Fibrosis in Patients With Moderate to Severe COVID -19	China	Y	N	Drug Repurposing	Nintedanib	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04379518">NCT04379518</a>	Rintatolimod and IFN Alpha-2b for the Treatment of Mild or Moderate COVID-19 Infection in Cancer Patients	United States	N	N	Drug Repurposing	Rintatolimod, Interferon alpha-2b	Safety	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04374539">NCT04374539</a>	Plasma Exchange in Patients With COVID-19 Disease and Invasive Mechanical Ventilation: a Randomized Controlled Trial	Spain	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04325893">NCT04325893</a>	Hydroxychloroquine Versus Placebo in COVID-19 Patients at Risk for Severe Disease	France	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Mortality	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04322123">NCT04322123</a>	Safety and Efficacy of Hydroxychloroquine Associated With Azithromycin in SARS-Cov-2 Virus (COVID-19)	Brazil	Y	Y	Drug Repurposing	Hydroxychloroquine, Azithromycin	Efficacy - WHO scale	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04326036">NCT04326036</a>	Use of cSVF Via IV Deployment for Residual Lung Damage After Symptomatic COVID-19 Infection	United States	N	N	Cell/Blood based	ND:Stem cells	Safety	Other	
<a href="https://ClinicalTrials.gov/show/NCT04337918">NCT04337918</a>	Nitric Oxide Releasing Solutions to Prevent and Treat Mild/Moderate COVID-19 Infection	Canada	N	N	Shelved drug or NME	Nitric Oxide Releasing Solution	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP), Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04346693">NCT04346693</a>	An Open Randomized Study of Dalargin Effectiveness in Patients With Severe and Critical Manifestations of SARS-COVID-19	Russian Federation	Y	N	Shelved drug or NME	Dalargin	Efficacy - Viral load	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04322396">NCT04322396</a>	Proactive Prophylaxis With Azithromycin and hydroxyChloroquine in Hospitalized Patients With COVID-19	Denmark	Y	Y	Drug Repurposing	Azithromycin, Hydroxychloroquine	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04415073">NCT04415073</a>	A Phase 2 Study to Evaluate Axatilimab for Hospitalized Patients With Respiratory Involvement Secondary to COVID-19	United States	Y	N	Shelved drug or NME	Axatilimab	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04355637">NCT04355637</a>	Inhaled Corticosteroid Treatment of COVID19 Patients With Pneumonia	Spain	Y	N	Drug Repurposing	Budesonide	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04315480">NCT04315480</a>	Tocilizumab for SARS-CoV2 (COVID-19) Severe Pneumonitis	Italy	N	N	Drug Repurposing	Tocilizumab	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04399798">NCT04399798</a>	Baricitinib for coRona Virus pnEumonia (COVID-19): a THerapeutic Trial	Italy	N	N	Drug Repurposing	Baricitinib	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04363437">NCT04363437</a>	COlchicine in Moderate-severe Hospitalized Patients Before ARDS to Treat COVID-19	United States	Y	N	Drug Repurposing	Colchicine	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04406246">NCT04406246</a>	Prevention of Coronavirus Disease (COVID-19) Outbreaks With Nitazoxanide	Mexico	N	N	Drug Repurposing	Nitazoxanide	Efficacy - Other efficacy	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04341493">NCT04341493</a>	Hydroxychloroquine vs Nitazoxanide in Patients With COVID-19	Mexico	Y	N	Drug Repurposing	Nitazoxanide	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04322344">NCT04322344</a>	Escin in Patients With Covid-19 Infection	Italy	Y	Y	Drug Repurposing	Escin	Efficacy - Mortality	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04344041">NCT04344041</a>	COvid-19 and Vitamin D Supplementation: a Multicenter Randomized Controlled Trial of High Dose Versus Standard Dose Vitamin D3 in High-risk COVID-19 Patients (CoVitTrial)	France	Y	N	Drug Repurposing	Vitamin D3	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases, Other	
<a href="http://www.ensaiosclinicos.gov.br/rg/RBR-3cbs3w/">RBR-3cbs3w</a>	Randomized, pragmatic, open study evaluating Hydroxychloroquine for prevention of Hospitalization and Respiratory Complications in outpatients with confirmed or presumptive diagnosis of Infection by (COVID-19)	Brazil	Y	Y	Drug Repurposing	Hydroxychloroquine	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04384458">NCT04384458</a>	COVID-19 Prophylaxis With Hydroxychloroquine Associated With Zinc For High-Risk Healthcare Workers	Brazil	N	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04403685">NCT04403685</a>	Safety and Efficacy of Tocilizumab in Moderate to Severe COVID-19 With Inflammatory Markers	Brazil	Y	N	Drug Repurposing	Tocilizumab	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04382768">NCT04382768</a>	Inhaled Ibuprofen to Treat COVID-19	Argentina	N	N	Drug Repurposing	Ibuprofen	Efficacy - WHO scale	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04414631">NCT04414631</a>	Conestat Alfa in the Prevention of Severe SARS-CoV-2 Infection in Hospitalized Patients With COVID-19	Switzerland	Y	N	Drug Repurposing	Conestat alfa	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04368377">NCT04368377</a>	Enhanced Platelet Inhibition in Critically Ill Patients With COVID-19	Italy	N	N	Drug Repurposing	Tirofiban, Clopidogrel, Aspirin, Fondaparinux	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04365309">NCT04365309</a>	Protective Effect of Aspirin on COVID-19 Patients	China	Y	N	Drug Repurposing	Aspririn	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04312243">NCT04312243</a>	NO Prevention of COVID-19 for Healthcare Providers	United States	Y	N	Drug Repurposing	Nitric oxide	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04406064">NCT04406064</a>	Viral Specific T-cells for Treatment of COVID-19	United States	N	N	Cell/Blood based	ND:T-cells	Other	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04357613">NCT04357613</a>	IMATINIB IN COVID-19 DISEASE IN AGED PATIENTS.	France	Y	N	Drug Repurposing	Imatinib	Safety	Other	
<a href="https://ClinicalTrials.gov/show/NCT04363840">NCT04363840</a>	The LEAD COVID-19 Trial: Low-risk, Early Aspirin and Vitamin D to Reduce COVID-19 Hospitalizations	United States	Y	N	Drug Repurposing	Aspirin, Vitamin D3	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04371523">NCT04371523</a>	Hydroxychloroquine to Prevent COVID-19 Disease Amongst Healthcare Workers	Canada	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04333654">NCT04333654</a>	Hydroxychloroquine in Outpatient Adults With COVID-19	United States	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04345887">NCT04345887</a>	Spironolactone in Covid-19 Induced ARDS	Turkey	Y	N	Drug Repurposing	Spironolactone	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04358783">NCT04358783</a>	Convalescent Plasma Compared to the Best Available Therapy for the Treatment of SARS-CoV-2 Pneumonia	Mexico	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Mortality	Mild/Moderate Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001435-27/FR">2020-001435-27</a>	Home treatment of elderly patients with symptomatic SARS-CoV-2 infection (COVID-19) : a multiarm, multi-stage (MAMS) randomized trial to assess the efficacy and safety of several experimental treatments to reduce the risk of hospitalization or death (COVERAGE trial)	France	Y	Y	Drug Repurposing	Favipiravir, Hydroxychloroquine, Imatinib, Telmisartan	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04334629">NCT04334629</a>	LIBERATE Trial in COVID-19	United Kingdom	Y	N	Drug Repurposing	Ibuprofen	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04324463">NCT04324463</a>	Anti-Coronavirus Therapies to Prevent Progression of Coronavirus Disease 2019 (COVID-19) Trial	Canada	Y	N	Drug Repurposing	Cholchicine, Interferon-beta, Aspirin, Rivaroxaban	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04377672">NCT04377672</a>	Human Convalescent Plasma for High Risk Children Exposed or Infected With SARS-CoV-2 (COVID-19)	United States	N	N	Cell/Blood based	ND:Convalescent plasma	Safety	Other	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-002448-21/GR">2020-002448-21</a>	A RANDOMIZED CLINICAL TRIAL FOR ENHANCED TRAINED IMMUNE RESPONSES THROUGH BACILLUS CALMETTE-GU&Eacute;RIN VACCINATION TO PREVENT INFECTIONS ?? COVID-19: THE ACTIVATE II TRIAL	Greece	Y	N	Vaccine	ND:BCG vaccine	Efficacy - Infection rate (prevention)	General population	
<a href="https://ClinicalTrials.gov/show/NCT04418531">NCT04418531</a>	Convalescent Antibodies Infusion in COVID 19 Patients	Italy	N	N	Cell/Blood based	ND:Immunoglobulin	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04321278">NCT04321278</a>	Safety and Efficacy of Hydroxychloroquine Associated With Azithromycin in SARS-CoV2 Virus (Coalition Covid-19 Brasil II)	Brazil	Y	Y	Drug Repurposing	Azithromycin, Hydroxychloroquine	Efficacy - WHO scale	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04345614">NCT04345614</a>	A Study of CM4620-Injectable Emulsion (IE) in Patients With Severe COVID-19 Pneumonia	United States	Y	N	Shelved drug or NME	CM4620	Efficacy - WHO scale	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04321174">NCT04321174</a>	COVID-19 Ring-based Prevention Trial With Lopinavir/Ritonavir	Canada	Y	N	Drug Repurposing	Lopinavir/ritonavir	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04376684">NCT04376684</a>	Investigating Otilimab in Patients With Severe Pulmonary COVID-19 Related Disease	United States	Y	N	Shelved drug or NME	Otilimab	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04393792">NCT04393792</a>	SINUS WASH Pilot Study in Adults Testing Positive for COVID-19	United Kingdom	Y	N	Shelved drug or NME	Povidone-Iodine	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT02735707">NCT02735707</a>	Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia	Netherlands	Y	Y	Drug Repurposing	Hydrocortisone, Ceftriaxone, Moxifloxacin, Levofloxacin, Piperacillin-tazobactam, Ceftaroline, Amoxicillin-clavulanate, Oseltamivir, Lopinavir/ritonavir, Hydroxychloroquine, Interferon-beta1a, Anakinra, Tocilizumab, Sarilumab	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04293887">NCT04293887</a>	Efficacy and Safety of IFN-a2ß in the Treatment of Novel Coronavirus Patients	China	Y	N	Drug Repurposing	Interferon alpha-1b	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04327401">NCT04327401</a>	COVID-19-associated ARDS Treated With Dexamethasone: Alliance Covid-19 Brasil III	Brazil	Y	N	Drug Repurposing	Dexamethasone	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04342156">NCT04342156</a>	Safety And Efficacy Of Hydroxychloroquine For At Risk Population (SHARP) Against COVID-19	Singapore	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04389385">NCT04389385</a>	COVID-19 Specific T Cell Derived Exosomes (CSTC-Exo)	Turkey	N	N	Cell/Blood based	COVID-19 Specific T Cell derived exosomes	Safety	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04387409">NCT04387409</a>	Study to Assess VPM1002 in Reducing Healthcare Professionals' Absenteeism in COVID-19 Pandemic	Germany	Y	N	Vaccine	ND:VPM1002 vaccine	Efficacy - Other efficacy	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04371601">NCT04371601</a>	Safety and Effectiveness of Mesenchymal Stem Cells in the Treatment of Pneumonia of Coronavirus Disease 2019	China	Y	N	Cell/Blood based	ND:Stem cells	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04260594">NCT04260594</a>	Clinical Study of Arbidol Hydrochloride Tablets in the Treatment of Pneumonia Caused by Novel Coronavirus	China	Y	N	Drug Repurposing	Umifenovir	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04336748">NCT04336748</a>	HCQ for Primary Prophylaxis Against COVID19 in Health-care Workers	Austria	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04383717">NCT04383717</a>	Levamisole and Isoprinosine in the Treatment of COVID19: A Proposed Therapeutic Trial	Egypt	Y	N	Drug Repurposing	Levamisole, Isoprinosine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04429555">NCT04429555</a>	Efficacy, Safety, Tolerability, and Biomarkers of MN-166 (Ibudilast) in Patients Hospitalized With COVID-19 and at Risk for ARDS	United States	Y	N	Drug Repurposing	Ibudilast	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04346589">NCT04346589</a>	Convalescent Antibodies Infusion in Critically Ill COVID 19 Patients	Italy	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04340349">NCT04340349</a>	Low-dose Hydroxychloroquine and Bromhexine: a Novel Regimen for COVID-19 Prophylaxis in Healthcare Professionals	Mexico	Y	N	Drug Repurposing	Hydroxychloroquine, Bromhexine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04439006">NCT04439006</a>	Ibrutinib for the Treatment of COVID-19 in Patients Requiring Hospitalization	United States	Y	N	Drug Repurposing	Ibrutinib	Efficacy - Oxygen parameters	Other	
<a href="https://ClinicalTrials.gov/show/NCT03042143">NCT03042143</a>	Repair of Acute Respiratory Distress Syndrome by Stromal Cell Administration (REALIST) (COVID-19)	United Kingdom	Y	N	Cell/Blood based	ND:Stem cells	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04359810">NCT04359810</a>	Plasma Therapy of COVID-19 in Critically Ill Patients	United States	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04252274">NCT04252274</a>	Efficacy and Safety of Darunavir and Cobicistat for Treatment of COVID-19	China	Y	N	Drug Repurposing	Darunavir, Cobicistat	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04385186">NCT04385186</a>	Inactivated Convalescent Plasma as a Therapeutic Alternative in Patients CoViD-19	Colombia	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04305457">NCT04305457</a>	Nitric Oxide Gas Inhalation Therapy for Mild/Moderate COVID-19	United States	Y	N	Drug Repurposing	Nitric oxide	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04320277">NCT04320277</a>	Baricitinib in Symptomatic Patients Infected by COVID-19: an Open-label, Pilot Study.	Italy	N	N	Drug Repurposing	Baricitinib	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04397497">NCT04397497</a>	Mavrilimumab in Severe COVID-19 Pneumonia and Hyper-inflammation (COMBAT-19)	Italy	Y	N	Shelved drug or NME	Mavrilimumab	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04369794">NCT04369794</a>	COVID-19: BCG As Therapeutic Vaccine, Transmission Limitation, and Immunoglobulin Enhancement	Brazil	Y	N	Vaccine	BCG vaccine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04353128">NCT04353128</a>	Efficacy of Melatonin in the Prophylaxis of Coronavirus Disease 2019 (COVID-19) Among Healthcare Workers.	Spain	Y	N	Drug Repurposing	Melatonin	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04365985">NCT04365985</a>	Study of Immunomodulation Using Naltrexone and Ketamine for COVID-19	United States	Y	Y	Drug Repurposing	Naltrexone, Ketamine	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04352946">NCT04352946</a>	HEalth Care Worker pROphylaxis Against COVID-19: The HERO Trial	United States	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04331613">NCT04331613</a>	Safety and Efficacy of CAStem for Severe COVID-19 Associated With/Without ARDS	China	N	N	Cell/Blood based	ND:Stem cells	Safety	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04334967">NCT04334967</a>	Hydroxychloroquine in Patients With Newly Diagnosed COVID-19 Compared to Standard of Care	United States	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04363827">NCT04363827</a>	Protect: Study With Hydroxychloroquine for Prevention and Early Phase Treatment of Coronavirus Disease (COVID-19)	Italy	Y	Y	Drug Repurposing	Hydroxychloroquine	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04340050">NCT04340050</a>	COVID-19 Convalescent Plasma	United States	N	N	Cell/Blood based	ND:Convalescent plasma	Other	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04363450">NCT04363450</a>	Hydroxychloroquine as Prophylaxis for COVID-19 in Healthcare Workers (HCQPreP)	United States	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04335786">NCT04335786</a>	Valsartan for Prevention of Acute Respiratory Distress Syndrome in Hospitalized Patients With SARS-COV-2 (COVID-19) Infection Disease	Netherlands	Y	N	Drug Repurposing	Valsartan	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04446429">NCT04446429</a>	Anti-Androgen Treatment for COVID-19	Brazil	Y	N	Drug Repurposing	Dutasteride	Efficacy - Clinical improvement (except WHO scale)	Other	
<a href="https://ClinicalTrials.gov/show/NCT04321616">NCT04321616</a>	The Efficacy of Different Anti-viral Drugs in COVID 19 Infected Patients	Norway	Y	Y	Drug Repurposing, Shelved drug or NME	Hydroxychloroquine, Remdesivir	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04263402">NCT04263402</a>	The Efficacy of Different Hormone Doses in 2019-nCoV Severe Pneumonia	China	N	Y	Drug Repurposing	Methylprednisolone	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04392778">NCT04392778</a>	Clinical Use of Stem Cells for the Treatment of Covid-19	Turkey	Y	N	Cell/Blood based	ND:Stem cells	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases, Other	
<a href="https://ClinicalTrials.gov/show/NCT04407182">NCT04407182</a>	Safety and Efficacy of Viusid and Asbrip in Hospitalized Patients Infected by SARS-Cov-2 With COVID-19	Ecuador	Y	N	Shelved drug or NME	Viusid/Asbrip	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04424134">NCT04424134</a>	BromhexIne And Spironolactone For Coron?VirUs Infection Requiring HospiTalization	Russian Federation	Y	N	Drug Repurposing	Bromhexine, Spironolactone	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04332666">NCT04332666</a>	Angiotensin-(1,7) Treatment in COVID-19: the ATCO Trial	Belgium	Y	N	Drug Repurposing	Angiotensin 1-7	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04332991">NCT04332991</a>	Outcomes Related to COVID-19 Treated With Hydroxychloroquine Among In-patients With Symptomatic Disease	United States	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - WHO scale	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04397692">NCT04397692</a>	Inhaled NO for the Treatment of COVID-19 Caused by SARS-CoV-2 (US Trial)	United States	Y	N	Drug Repurposing	Nitric oxide	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04433078">NCT04433078</a>	RepurpoSing Old Drugs TO SuppRess a Modern Threat: COVID-19 STORM	United States	Y	N	Drug Repurposing	Doxycycline	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04382547">NCT04382547</a>	Treatment of Covid-19 Associated Pneumonia With Allogenic Pooled Olfactory Mucosa-derived Mesenchymal Stem Cells	Belarus	N	N	Cell/Blood based	ND:Stem cells	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04374565">NCT04374565</a>	Convalescent Plasma for Treatment of COVID-19 Patients With Pneumonia	United States	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04298060">NCT04298060</a>	DAS181 for Patients With Severe Hospitalized Flu and SAD-RVs (COVID-19)	China	Y	Y	Shelved drug or NME	DAS181	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04343651">NCT04343651</a>	Study to Evaluate the Efficacy and Safety of Leronlimab for Mild to Moderate COVID-19	United States	Y	N	Shelved drug or NME	Leronlimab	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04384380">NCT04384380</a>	Efficacy and Tolerability of Hydroxychloroquine in Adult Patients With COVID-19	Taiwan	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04381364">NCT04381364</a>	Inhalation of Ciclesonide for Patients With COVID-19: A Randomised Open Treatment Study (HALT COVID-19)	Sweden	Y	N	Drug Repurposing	Ciclesonide	Efficacy - Oxygen parameters	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04321096">NCT04321096</a>	The Impact of Camostat Mesilate on COVID-19 Infection	Denmark	Y	N	Drug Repurposing	Camostat	Efficacy - WHO scale	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04355962">NCT04355962</a>	Sevoflurane in COVID-19 ARDS (SevCov)	Switzerland	Y	N	Drug Repurposing	Sevoflurane	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04333368">NCT04333368</a>	Cell Therapy Using Umbilical Cord-derived Mesenchymal Stromal Cells in SARS-CoV-2-related ARDS	France	Y	N	Cell/Blood based	ND:Stem cells	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04416399">NCT04416399</a>	STerOids in COVID-19 Study	United Kingdom	Y	N	Drug Repurposing	Budesonide	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04381377">NCT04381377</a>	Efficacy and Safety of Polyoxidonium  in Hospitalized Patients With Coronavirus Disease COVID-19	Russian Federation	Y	N	Drug Repurposing	Azoximer bromide	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04349228">NCT04349228</a>	Assessment of the Efficacy and Safety of (HCQ) as a Prophylaxis for COVID19 for Health Professionals	Tunisia	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04347239">NCT04347239</a>	Study to Evaluate the Efficacy and Safety of Leronlimab for Patients With Severe or Critical Coronavirus Disease 2019 (COVID-19)	United States	Y	N	Shelved drug or NME	Leronlimab	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04403100">NCT04403100</a>	Hydroxychloroquine and Lopinavir/ Ritonavir to Improve the Health of People With COVID-19: "The Hope Coalition - 1"	Brazil	Y	N	Drug Repurposing	Hydroxychloroquine, Lopinavir/Ritonavir	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04403243">NCT04403243</a>	COLchicine Versus Ruxolitinib and Secukinumab In Open Prospective Randomized Trial	Russian Federation	Y	Y	Drug Repurposing	Colchicine, Ruxolitinib, Secukinumab	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04442230">NCT04442230</a>	NasoVAX in Patients With Early Coronavirus Infectious Disease 2019 (COVID-19)	United States	Y	N	Vaccine	ND:NasoVAX	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04361474">NCT04361474</a>	Trial Evaluating the Efficacy of Local Budesonide Therapy in the Management of Hyposmia in COVID-19 Patients Without Signs of Severity	France	Y	N	Drug Repurposing	Budesonide	Other	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04402957">NCT04402957</a>	LSALT Peptide vs. Placebo to Prevent ARDS and Acute Kidney Injury in Patients Infected With SARS-CoV-2 (COVID-19)	Canada	Y	N	Shelved drug or NME	LSALT peptide	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04448756">NCT04448756</a>	M5049 Study in Participants With Coronavirus Disease 2019 (COVID-19) Pneumonia	United States	Y	N	Shelved drug or NME	M5049	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04349098">NCT04349098</a>	Evaluation of Activity and Safety of Oral Selinexor in Participants With Severe COVID-19 Infection	United States	Y	N	Drug Repurposing	Selinexor	Efficacy - WHO scale	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04332380">NCT04332380</a>	Convalescent Plasma for Patients With COVID-19: A Pilot Study	Colombia	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04355676">NCT04355676</a>	Evaluation of Activity and Safety of Two Regimens of Low Dose Oral Selinexor in Participants With Moderate or Severe COVID-19	United States	N	N	Drug Repurposing	Selinexor	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04395716">NCT04395716</a>	A Study of ResCure  to Treat COVID-19 Infection	United States	N	N	Shelved drug or NME	ResCure	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04419623">NCT04419623</a>	A Study of TL-895 With Standard Available Treatment Versus Standard Available Treatment for the Treatment of COVID-19 in Patients With Cancer	United States	Y	N	Shelved drug or NME	TL-895	Other	Other	
<a href="https://ClinicalTrials.gov/show/NCT04437823">NCT04437823</a>	Efficacy of Intravenous Infusions of Stem Cells in the Treatment of COVID-19 Patients	Pakistan	Y	N	Cell/Blood based	ND:Stem cells	Safety	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04402060">NCT04402060</a>	A Study of APL-9 in Adults With Mild to Moderate ARDS Due to COVID-19	United States	Y	N	Shelved drug or NME	APL-9	Safety	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04371978">NCT04371978</a>	Efficacy and Safety of Dipeptidyl Peptidase-4 Inhibitors in Diabetic Patients With Established COVID-19	Israel	Y	N	Drug Repurposing	Linagliptin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Other	
<a href="https://ClinicalTrials.gov/show/NCT04332835">NCT04332835</a>	Convalescent Plasma for Patients With COVID-19: A Randomized, Open Label, Parallel, Controlled Clinical Study	Colombia	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04312009">NCT04312009</a>	Losartan for Patients With COVID-19 Requiring Hospitalization	United States	Y	N	Drug Repurposing	Losartan	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases, Mild/Moderate Cases, Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04315948">NCT04315948</a>	Trial of Treatments for COVID-19 in Hospitalized Adults	France	Y	Y	Drug Repurposing, Shelved drug or NME	Remdesivir, Lopinavir/ritonavir, Interferon beta-1a, Hydroxychloroquine	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04311177">NCT04311177</a>	Losartan for Patients With COVID-19 Not Requiring Hospitalization	United States	Y	N	Drug Repurposing	Losartan	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04402970">NCT04402970</a>	Dornase Alfa for ARDS in Patients With SARS-CoV-2	United States	N	N	Drug Repurposing	Dornase alfa	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04335084">NCT04335084</a>	A Study of Hydroxychloroquine, Vitamin C, Vitamin D, and Zinc for the Prevention of COVID-19 Infection	United States	N	N	Drug Repurposing	Hydroxychloroquine, Ascorbic acid, Vitamin D3, Zinc	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04264858">NCT04264858</a>	Treatment of Acute Severe 2019-nCoV Pneumonia With Immunoglobulin From Cured Patients	China	Y	N	Cell/Blood based	ND:Immunoglobulin	Efficacy - WHO scale	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04322565">NCT04322565</a>	Colchicine Counteracting Inflammation in COVID-19 Pneumonia	Italy	Y	N	Drug Repurposing	Colchicine	Efficacy - WHO scale	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04341935">NCT04341935</a>	Effects of DPP4 Inhibition on COVID-19	United States	Y	N	Drug Repurposing	Linagliptin	Other	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04367077">NCT04367077</a>	MultiStem Administration for COVID-19 Induced ARDS (MACoVIA)	United States	Y	N	Cell/Blood based	ND:Stem cells	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04365101">NCT04365101</a>	Natural Killer Cell (CYNK-001) Infusions in Adults With COVID-19 (CYNK-001-COVID-19)	United States	Y	N	Cell/Blood based	ND:CYNK-001	Safety	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04370834">NCT04370834</a>	Tocilizumab for Patients With Cancer and COVID-19 Disease	United States	N	N	Drug Repurposing	Tocilizumab	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases, Other	
<a href="https://ClinicalTrials.gov/show/NCT04275414">NCT04275414</a>	Bevacizumab in Severe or Critical Patients With COVID-19 Pneumonia	China	N	N	Drug Repurposing	Bevacizumab	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04421664">NCT04421664</a>	Preemptive Therapy for SARS-Coronavirus-2 (COVID-19 PEP Canada)	United States	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04360096">NCT04360096</a>	Inhaled Aviptadil for the Treatment of Moderate and Severe COVID-19	United States	Y	N	Shelved drug or NME, Other	Aviptadil, ND:Device	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04342169">NCT04342169</a>	University of Utah COVID-19 Hydrochloroquine Trial	United States	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04320238">NCT04320238</a>	Experimental Trial of rhIFNa Nasal Drops to Prevent 2019-nCOV in Medical Staff	China	N	Y	Drug Repurposing	Interferon alpha, Thymosin alpha	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04327349">NCT04327349</a>	Investigating Effect of Convalescent Plasma on COVID-19 Patients Outcome: A Clinical Trial	Iran	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04400019">NCT04400019</a>	Prevention of COVID19 Infection in Nursing Homes by Chemoprophylaxis With Hydroxychloroquine (PREVICHARM)	Spain	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Other	
<a href="https://ClinicalTrials.gov/show/NCT04433546">NCT04433546</a>	PB1046, a Long-acting, Sustained Release Human VIP Analogue, Intended to Provide Clinical Improvement to Hospitalized COVID-19 Patients at High Risk for Rapid Clinical Deterioration and Acute Respiratory Distress Syndrome (ARDS).	United States	Y	N	Shelved drug or NME	PB1046	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04357730">NCT04357730</a>	Fibrinolytic Therapy to Treat ARDS in the Setting of COVID-19 Infection	United States	Y	N	Drug Repurposing	Alteplase	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04407208">NCT04407208</a>	Convalescent Plasma Therapy in Patients With COVID-19	Indonesia	N	N	Cell/Blood based	ND:Convalescent plasma	Safety	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04394377">NCT04394377</a>	Full Anticoagulation Versus Prophylaxis in COVID-19: COALIZAO ACTION Trial	Brazil	Y	N	Drug Repurposing	Rivaroxaban	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04453371">NCT04453371</a>	Impact of Tissue Plasminogen Activator (tPA) Treatment for an Atypical Acute Respiratory Distress Syndrome (COVID-19)	Russian Federation	Y	N	Drug Repurposing	Alteplase	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04342650">NCT04342650</a>	Chloroquine Diphosphate in the Prevention of SARS in Covid-19 Infection	Brazil	Y	N	Drug Repurposing	Chloroquine	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04452565">NCT04452565</a>	NA-83, Atazanavir and Dexamethasone Combination Therapy for the Treatment of COVID-19 Infection	United States	Y	Y	Drug Repurposing	Atazanavir, Dexamethasone	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04324606">NCT04324606</a>	A Study of a Candidate COVID-19 Vaccine (COV001)	United Kingdom	N	Y	Vaccine	ND:Vaccine, Paracetamol	Safety	General population	
<a href="https://ClinicalTrials.gov/show/NCT04373733">NCT04373733</a>	Early Intervention in COVID-19: Favipiravir Verses Standard Care	United Kingdom	Y	Y	Drug Repurposing	Favipiravir	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04459702">NCT04459702</a>	A Study of Combination Therapies to Treat COVID-19 Infection	United States	Y	Y	Drug Repurposing	Lopinavir, Ritonavir, Azithromycin, Hydroxychloroquine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04400838">NCT04400838</a>	Investigating a Vaccine Against COVID-19	United Kingdom	Y	Y	Vaccine	ND:Vaccine	Efficacy - Infection rate (prevention)	General population	
<a href="https://ClinicalTrials.gov/show/NCT04344379">NCT04344379</a>	Prevention of SARS-CoV-2 in Hospital Workers s Exposed to the Virus	France	Y	Y	Drug Repurposing	Hydroxychloroquine, Azithromycin	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04268537">NCT04268537</a>	Immunoregulatory Therapy for 2019-nCoV	China	Y	Y	Drug Repurposing	Anti-PD-1(NOS), Thymosin alpha	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04355052">NCT04355052</a>	Open Label Study to Compare Efficacy, Safety and Tolerability of Hydroxychloroquine Combined With Azithromycin Compared to Hydroxychloroquine Combined With Camostat Mesylate and to "no Treatment" in SARS CoV 2 Virus	Israel	Y	Y	Drug Repurposing	Azithromycin, Camostat	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04330495">NCT04330495</a>	Randomized, Controlled, Double-blind Clinical Trial Comparing the Efficacy and Safety of Chemoprophylaxis With Hydroxychloroquine in Patients Under Biological Treatment and / or JAK Inhibitors in the Prevention of SARS-CoV-2 Infection	Spain	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Other	
<a href="https://ClinicalTrials.gov/show/NCT04447781">NCT04447781</a>	Safety, Tolerability and Immunogenicity of INO-4800 Followed by Electroporation in Healthy Volunteers for COVID19	Korea, Republic of	Y	Y	Vaccine, Other	ND:Vaccine INO-4800, ND:Device	Safety	Other	
<a href="https://ClinicalTrials.gov/show/NCT04447235">NCT04447235</a>	Early Treatment With Ivermectin and LosarTAN for Cancer Patients With COVID-19 Infection	Brazil	Y	N	Drug Repurposing	Losartan, Ivermectin	Efficacy - Clinical improvement (except WHO scale)	Other	
<a href="https://ClinicalTrials.gov/show/NCT04405739">NCT04405739</a>	The Safety of EIDD-2801 and Its Effect on Viral Shedding of SARS-CoV-2 (The END-COVID Study)	United States	Y	Y	Shelved drug or NME	EIDD-2801	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04447404">NCT04447404</a>	DUR-928 in Subjects With SARS-CoV-2 With Acute Liver or Kidney Injury	United States	Y	N	Shelved drug or NME	DUR-928	Efficacy - Mortality	Other	
<a href="https://ClinicalTrials.gov/show/NCT04261426">NCT04261426</a>	The Efficacy of Intravenous Immunoglobulin Therapy for Severe 2019-nCoV Infected Pneumonia	China	N	N	Cell/Blood based	ND:Immunoglobulin	Efficacy - WHO scale	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04386070">NCT04386070</a>	Preventing Pulmonary Complications in Surgical Patients at Risk of COVID-19	United Kingdom	Y	Y	Drug Repurposing	Lopinavir-Ritonavir, Hydroxychloroquine	Efficacy - Infection rate (prevention)	Other	
<a href="https://ClinicalTrials.gov/show/NCT04255017">NCT04255017</a>	A Prospective/Retrospective,Randomized Controlled Clinical Study of Antiviral Therapy in the 2019-nCoV Pneumonia	China	Y	Y	Drug Repurposing	Oseltamivir, Lopinavir/ritonavir	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04254874">NCT04254874</a>	A Prospective/Retrospective,Randomized Controlled Clinical Study of Interferon Atomization in the 2019-nCoV Pneumonia	China	Y	N	Drug Repurposing	Peg-Interferon alpha-2b	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04408235">NCT04408235</a>	High Versus Low LMWH Dosages in Hospitalized Patients With Severe COVID-19 Pneumonia and Coagulopathy	Italy	Y	N	Drug Repurposing	Enoxaparin	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04261270">NCT04261270</a>	A Randomized,Open,Controlled Clinical Study to Evaluate the Efficacy of ASC09F and Ritonavir for 2019-nCoV Pneumonia	China	N	Y	Drug Repurposing, Shelved drug or NME	Ritonavir, Oseltamivir, ASC09F	Efficacy - Oxygen parameters	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04350281">NCT04350281</a>	Double Therapy With IFN-beta 1b and Hydroxychloroquine	Hong Kong	Y	N	Drug Repurposing	Interferon beta-1b	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04332042">NCT04332042</a>	TOFAcitinib in SARS-CoV2 Pneumonia	Italy	Y	N	Drug Repurposing	Tofacitinib	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04371393">NCT04371393</a>	MSCs in COVID-19 ARDS	United States	Y	N	Cell/Blood based	ND:Remestemcel-L 	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04467918">NCT04467918</a>	CANnabiDiol for CoviD-19 pATiEnts With Mild to Moderate Symptoms	Brazil	Y	N	Drug Repurposing	Cannabidiol	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04357366">NCT04357366</a>	suPAR-guided Anakinra Treatment for Validation of the Risk and Management of Respiratory Failure by COVID-19 (SAVE)	Greece	N	N	Drug Repurposing	Anakinra, Trimethoprim/sulfamethoxazole	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04346667">NCT04346667</a>	Post-Exposure Prophylaxis for Asymptomatic SARS-CoV-2 COVID-19 Patients With choloroquinE Compounds	Pakistan	Y	Y	Drug Repurposing	Hydroxychloroquine, Chloroquine	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04355429">NCT04355429</a>	Efficacy of Captopril in Covid-19 Patients With Severe Acute Respiratory Syndrome (SARS) CoV-2 Pneumonia (CAPTOCOVID)	France	Y	N	Drug Repurposing	Captopril	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04420247">NCT04420247</a>	Efficacy of Chloroquine or Hydroxychloroquine in Treating Pneumonia Caused by SARS-Cov-2 - COVID-19	Brazil	Y	N	Drug Repurposing	Hydroxychloroquine, Chloroquine	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04356482">NCT04356482</a>	CONVALESCENT PLASMA FOR ILL PATIENTS BY COVID-19	Mexico	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04311697">NCT04311697</a>	Intravenous Aviptadil for Critical COVID-19 With Respiratory Failure	United States	Y	N	Shelved drug or NME	Aviptadil	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04419025">NCT04419025</a>	Efficacy of N-Acetylcysteine (NAC) in Preventing COVID-19 From Progressing to Severe Disease	United States	Y	N	Drug Repurposing	N-acetylcysteine	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04407507">NCT04407507</a>	Efficacy, Safety and Tolerability of Ivermectin in Subjects Infected With SARS-CoV-2 With or Without Symptoms	Mexico	Y	N	Drug Repurposing	Ivermectin	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04479644">NCT04479644</a>	Safety, Tolerability, and Pharmacokinetics Study of Human Monoclonal Antibody BRII-198	China	Y	N	Shelved drug or NME	BRII-198	Safety	Other	
<a href="https://ClinicalTrials.gov/show/NCT04479631">NCT04479631</a>	Safety, Tolerability, and Pharmacokinetics Study of Human Monoclonal Antibody BRII-196	China	Y	N	Shelved drug or NME	BRII-196	Safety	Other	
<a href="https://ClinicalTrials.gov/show/NCT04357782">NCT04357782</a>	Administration of Intravenous Vitamin C in Novel Coronavirus Infection (COVID-19) and Decreased Oxygenation	United States	N	N	Drug Repurposing	Ascorbic acid	Safety	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04400799">NCT04400799</a>	Enoxaparin for Primary Thromboprophylaxis in Ambulatory Patients With COVID-19	Switzerland	Y	N	Drug Repurposing	Enoxaparin	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04344184">NCT04344184</a>	Early Infusion of Vitamin C for Treatment of Novel COVID-19 Acute Lung Injury (EVICT-CORONA-ALI)	United States	Y	N	Drug Repurposing	Ascorbic acid	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04378244">NCT04378244</a>	CORONA: A Study Using DeltaRex-G Gene Therapy for Symptomatic COVID-19	United States	N	N	Shelved drug or NME	DeltaRex-G	Safety	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04333914">NCT04333914</a>	Prospective Study in Patients With Advanced or Metastatic Cancer and SARS-CoV-2 Infection	France	Y	Y	Drug Repurposing, Shelved drug or NME	GNS651, Nivolumab, Tocilizumab, Avdoralimab, Monalizumab	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04398147">NCT04398147</a>	Phase I/II Clinical Trial of Recombinant Novel Coronavirus Vaccine (Adenovirus Type 5 Vector) in Canada	Canada	Y	Y	Vaccine	ND:Ad5-nCoV	Safety	General population	
<a href="https://ClinicalTrials.gov/show/NCT04327206">NCT04327206</a>	BCG Vaccination to Protect Healthcare Workers Against COVID-19	Australia	Y	N	Drug Repurposing, Vaccine	BCG Vaccine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04466098">NCT04466098</a>	Multiple Dosing of Mesenchymal Stromal Cells in Patients With ARDS (COVID-19)	United States	Y	N	Cell/Blood based	ND:MSC	Safety	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04334512">NCT04334512</a>	A Study of Quintuple Therapy to Treat COVID-19 Infection	United States	N	N	Drug Repurposing	Hydroxychloroquine, Azithromycin, Ascorbic acid, Vitamin D3, Zinc	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04328961">NCT04328961</a>	Hydroxychloroquine for COVID-19 Post-exposure Prophylaxis (PEP)	United States	Y	Y	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	General population	
<a href="https://ClinicalTrials.gov/show/NCT04425733">NCT04425733</a>	MK-5475 in Participants With Hypoxemia Due to COVID-19 Pneumonia (MK-5475-009)	United States	Y	N	Shelved drug or NME	MK-5475	Safety	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04461379">NCT04461379</a>	Prevention, Efficacy and Safety of BCG Vaccine in COVID-19 Among Healthcare Workers	Mexico	Y	N	Vaccine	ND:Vaccine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04392232">NCT04392232</a>	A Study of COVID 19 Convalescent Plasma in High Risk Patients With COVID 19 Infection	United States	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04339712">NCT04339712</a>	Personalised Immunotherapy for SARS-CoV-2 (COVID-19) Associated With Organ Dysfunction	Greece	N	N	Drug Repurposing	Anakinra, Tocilizumab	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04455958">NCT04455958</a>	Lopinavir/Ritonavir for the Treatment of COVID-19 Positive Patients With Cancer and Immune Suppression in the Last Year	United States	Y	N	Drug Repurposing	Lopinavir/Ritonavir	Efficacy - Clinical improvement (except WHO scale)	Other	
<a href="https://ClinicalTrials.gov/show/NCT04389580">NCT04389580</a>	Combination Therapy With Isotretinoin and Tamoxifen Expected to Provide Complete Protection Against Severe Acute Respiratory Syndrome Coronavirus	Egypt	Y	Y	Drug Repurposing	Isotretinoin, Tamoxifen	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04357106">NCT04357106</a>	COPLA Study: Treatment of Severe Forms of COronavirus Infection With Convalescent PLAsma	Mexico	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04334148">NCT04334148</a>	Healthcare Worker Exposure Response and Outcomes of Hydroxychloroquine	United States	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04333589">NCT04333589</a>	Corona Virus Disease 2019 Patients Whose Nucleic Acids Changed From Negative to Positive	China	Y	N	Drug Repurposing	Favipiravir	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04310228">NCT04310228</a>	Favipiravir Combined With Tocilizumab in the Treatment of Corona Virus Disease 2019	China	Y	Y	Drug Repurposing	Favipiravir, Tocilizumab	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04302519">NCT04302519</a>	Novel Coronavirus Induced Severe Pneumonia Treated by Dental Pulp Mesenchymal Stem Cells	China	N	N	Cell/Blood based	ND:Stem cells	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04370015">NCT04370015</a>	Hydroxychloroquine Chemoprophylaxis for COVID-19 Infection in High-risk Healthcare Workers.	Pakistan	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04435015">NCT04435015</a>	The Utility of Camostat Mesylate in Patients With COVID-19 Associated Coagulopathy (CAC) and Cardiovascular Complications	United States	Y	N	Drug Repurposing	Camostat	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04391179">NCT04391179</a>	Dipyridamole to Prevent Coronavirus Exacerbation of Respiratory Status (DICER) in COVID-19	United States	Y	N	Drug Repurposing	Dipyridamole	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04273763">NCT04273763</a>	Evaluating the Efficacy and Safety of Bromhexine Hydrochloride Tablets Combined With Standard Treatment/ Standard Treatment in Patients With Suspected and Mild Novel Coronavirus Pneumonia (COVID-19)	China	Y	N	Drug Repurposing	Bromhexine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04393727">NCT04393727</a>	Transfusion of Convalescent Plasma for the Early Treatment of Patients With COVID-19	Italy	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04490486">NCT04490486</a>	Umbilical Cord Tissue (UC) Derived Mesenchymal Stem Cells (MSCs) Versus Placebo to Treat Acute Pulmonary Inflammation Due to COVID-19	United States	Y	N	Cell/Blood based	ND:Stem cells	Safety	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04354155">NCT04354155</a>	COVID-19 Anticoagulation in Children - Thromboprophlaxis (COVAC-TP) Trial	United States	N	N	Drug Repurposing	Enoxaparin	Safety	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04435587">NCT04435587</a>	Ivermectin vs Combined Hydroxychloroquine and Antiretroviral Drugs (ART) Among Asymptomatic COVID-19 Infection	Thailand	Y	N	Drug Repurposing	Ivermectin	Safety	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04341441">NCT04341441</a>	Will Hydroxychloroquine Impede or Prevent COVID-19	United States	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04390217">NCT04390217</a>	LB1148 for Pulmonary Dysfunction Associated With COVID-19 Pneumonia	United States	Y	N	Shelved drug or NME	LB1148	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04445246">NCT04445246</a>	Inhaled Iloprost for Suspected COVID-19 Respiratory Failure	Qatar	N	N	Drug Repurposing	Iloprost	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04348461">NCT04348461</a>	BAttLe Against COVID-19 Using MesenchYmal Stromal Cells	Spain	Y	N	Cell/Blood based	ND:MSC	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04365517">NCT04365517</a>	The Effect of Sitagliptin Treatment in COVID-19 Positive Diabetic Patients	Italy	Y	N	Drug Repurposing	Sitagliptin	Efficacy - WHO scale	Mild/Moderate Cases, Other	
<a href="https://ClinicalTrials.gov/show/NCT04364009">NCT04364009</a>	Anakinra for COVID-19 Respiratory Symptoms	France	Y	N	Drug Repurposing	Anakinra	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04357860">NCT04357860</a>	Clinical Trial of Sarilumab in Adults With COVID-19	Spain	Y	N	Drug Repurposing	Sarilumab	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04355728">NCT04355728</a>	Use of UC-MSCs for COVID-19 Patients	United States	Y	N	Cell/Blood based	ND:Stem cells	Safety	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04471519">NCT04471519</a>	Whole-Virion Inactivated SARS-CoV-2 Vaccine (BBV152) for COVID-19 in Healthy Volunteers	India	Y	Y	Vaccine	BBV152 Vaccine	Safety	General population	
<a href="https://ClinicalTrials.gov/show/NCT04429529">NCT04429529</a>	Safety of TY027, a Treatment for COVID-19, in Humans	Singapore	Y	N	Shelved drug or NME	TY027	Safety	Other	
<a href="https://ClinicalTrials.gov/show/NCT04350086">NCT04350086</a>	Use of Dexmedetomidine in Light to Moderate Sedation in the Patient in the Palliative Situation of a Sars-cov-2 / COVID-19 Infection	France	N	N	Drug Repurposing	Dexmedetomidine	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04361253">NCT04361253</a>	Evaluation of SARS-CoV-2 (COVID-19) Antibody-containing Plasma thErapy	United States	Y	N	Cell/Blood based	Convalescent plasma	Efficacy - WHO scale	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04452097">NCT04452097</a>	Use of hUC-MSC Product (BX-U001) for the Treatment of COVID-19 With ARDS	United States	N	Y	Cell/Blood based	ND:Stem cells	Safety	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04380935">NCT04380935</a>	Effectiveness and Safety of Convalescent Plasma Therapy on COVID-19 Patients With Acute Respiratory Distress Syndrome	Indonesia	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04389450">NCT04389450</a>	Double-Blind, Multicenter, Study to Evaluate the Efficacy of PLX PAD for the Treatment of COVID-19	Israel	Y	Y	Shelved drug or NME	PLX-PAD	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04439071">NCT04439071</a>	A Study to Evaluate Efficacy and Safety of PTC299 in Hospitalized Participants With Coronavirus (COVID-19)	United States	Y	N	Shelved drug or NME	PTC299	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04483973">NCT04483973</a>	SPI-1005 Treatment in Severe COVID-19 Patients	United States	Y	N	Drug Repurposing	Ebselen	Safety	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04409834">NCT04409834</a>	Prevention of Arteriovenous Thrombotic Events in Critically-Ill COVID-19 Patients Trial	United States	Y	Y	Drug Repurposing	Heparin, Enoxaparin, Clopidogrel	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04303507">NCT04303507</a>	Chloroquine/ Hydroxychloroquine Prevention of Coronavirus Disease (COVID-19) in the Healthcare Setting	United Kingdom	Y	N	Drug Repurposing	Chloroquine, Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04484025">NCT04484025</a>	SPI-1005 Treatment in Moderate COVID-19 Patients	United States	Y	N	Drug Repurposing	Ebselen	Safety	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04347226">NCT04347226</a>	Anti-Interleukin-8 (Anti-IL-8) for Patients With COVID-19	United States	Y	N	Shelved drug or NME	BMS-986253	Efficacy - WHO scale	Other	
<a href="https://ClinicalTrials.gov/show/NCT04379492">NCT04379492</a>	A Study of Hydroxycholoroquine Compared to Placebo as Treatment for People With COVID-19	United States	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - WHO scale	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04369469">NCT04369469</a>	Efficacy and Safety Study of IV Ravulizumab in Patients With COVID-19 Severe Pneumonia	United States	Y	N	Drug Repurposing	Ravulizumab	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04482712">NCT04482712</a>	Effects of mTOR Inhibition With Sirolimus (RAPA) in Patients With COVID-19 to Moderate the Progression of ARDS	United States	Y	N	Drug Repurposing	Sirolimus	Efficacy - Mortality	Mild/Moderate Cases, Other	
<a href="https://ClinicalTrials.gov/show/NCT04328480">NCT04328480</a>	The ECLA PHRI COLCOVID Trial. Effects of Colchicine on Moderate/High-risk Hospitalized COVID-19 Patients.	Argentina	Y	N	Drug Repurposing	Colchicine	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04435522">NCT04435522</a>	Maraviroc in Patients With Moderate and Severe COVID-19	United States	N	N	Drug Repurposing	Maraviroc	Safety	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04357028">NCT04357028</a>	Measles Vaccine in HCW	Egypt	Y	N	Drug Repurposing, Vaccine	Measles Vaccine	Efficacy - Infection rate (prevention)	General population	
<a href="https://ClinicalTrials.gov/show/NCT04441918">NCT04441918</a>	Tolerability,Safety,Pharmacokinetic Profile and Immunogenicity of a Recombinant Humanized Anti-SARS-CoV-2 Monoclonal Antibody (JS016) for Injection in Chinese Health Subjects	China	Y	N	Shelved drug or NME	JS016	Safety	Other	
<a href="https://ClinicalTrials.gov/show/NCT04429854">NCT04429854</a>	Donated Antibodies Working Against nCoV	Belgium	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04483375">NCT04483375</a>	Safety, Tolerability and Pharmacokinetics of SCTA01, an Anti-SARS-CoV-2 Monoclonal Antibody, in Healthy Chinese Subjects	China	Y	N	Shelved drug or NME	SCTA01	Safety	Other	
<a href="https://ClinicalTrials.gov/show/NCT04356508">NCT04356508</a>	COVID-19: A Pilot Study of Adaptive Immunity and Anti-PD1	Hong Kong	N	N	Drug Repurposing	Nivolumab	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04458948">NCT04458948</a>	Open Label Non-comparative Trial of the Combination of Hydroxychloroquine and Azithromycin in the Treatment of Hospitalized Patients	United States	N	N	Drug Repurposing	Hydroxychloroquine, Azithromycin	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04359290">NCT04359290</a>	Ruxolitinib for Treatment of Covid-19 Induced Lung Injury ARDS	Germany	N	N	Drug Repurposing	Ruxolitinib	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04400929">NCT04400929</a>	Using GM-CSF as a Host Directed Therapeutic Against COVID-19	Singapore	Y	Y	Drug Repurposing	Sargramostim	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04346329">NCT04346329</a>	Immune Monitoring of Prophylactic Effect of Hydroxychloroquine in Healthcare Providers Highly Exposed to COVID-19	Colombia	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04335032">NCT04335032</a>	EPA-FFA to Treat Hospitalised Patients With COVID-19 (SARS-CoV-2)	United Kingdom	N	N	Shelved drug or NME	Eicosapentaenoic acid	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04401150">NCT04401150</a>	Lessening Organ Dysfunction With VITamin C - COVID-19	Canada	Y	N	Drug Repurposing	Ascorbic acid	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04365153">NCT04365153</a>	Canakinumab in Covid-19 Cardiac Injury (The Three C Study)	United States	Y	Y	Drug Repurposing	Canakinumab	Efficacy - WHO scale	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04382846">NCT04382846</a>	Novel Regimens in COVID-19 Treatment	Egypt	Y	Y	Drug Repurposing	Nitazoxanide, Ivermectin, Chloroquine, Azithromycin	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04401527">NCT04401527</a>	Treatment of Lung Injury From COVID-19 Infection With Intravenous Sodium Nitrite	United States	Y	N	Shelved drug or NME	Sodium Nitrite	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04421508">NCT04421508</a>	A Study to Assess Pulsed Inhaled Nitric Oxide vs Placebo in Subjects With Mild or Moderate COVID-19	United States	Y	N	Drug Repurposing	Nitric Oxide	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04453852">NCT04453852</a>	Monovalent Recombinant COVID19 Vaccine	Australia	Y	N	Vaccine	Covax-19 vaccine	Safety	General population	
<a href="https://ClinicalTrials.gov/show/NCT04405999">NCT04405999</a>	Prevention of Infection and Incidence of COVID-19 in Medical Personnel Assisting Patients With New Coronavirus Disease	Russian Federation	Y	N	Drug Repurposing	Bromhexine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04365439">NCT04365439</a>	Convalescent Plasma for COVID-19	Italy	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Viral load	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04472585">NCT04472585</a>	Efficacy of Subcutaneous Ivermectin With or Without Zinc and Nigella Sativa in COVID-19 Patients	Pakistan	Y	Y	Drug Repurposing, Other	Ivermectin, Zinc, ND:Nigella sativa	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04324021">NCT04324021</a>	Efficacy and Safety of Emapalumab and Anakinra in Reducing Hyperinflammation and Respiratory Distress in Patients With COVID-19 Infection.	Italy	Y	Y	Drug Repurposing	Emapalumab, Anakinra	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49612">ChiCTR2000029939</a>	A Single-blind, Randomized, Controlled Clinical Trial for Chloroquine Phosphate in the treatment of Novel Coronavirus Pneumonia 2019 (COVID-19)	China	Y	N	Drug Repurposing	Chloroquine	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49607">ChiCTR2000029935</a>	A Single-arm Clinical Trial for Chloroquine Phosphate in the treatment of Novel Coronavirus Pneumonia 2019 (COVID-19)	China	N	N	Drug Repurposing	Chloroquine	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49532">ChiCTR2000029853</a>	A randomized, open-label, controlled clinical trial for azvudine in the treatment of novel coronavirus pneumonia (COVID-19)	China	Y	N	Shelved drug or NME	Azvudine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49533">ChiCTR2000029850</a>	Effecacy and safty of convalescent plasma treatment for severe patients with novel coronavirus pneumonia (COVID-19): a prospective cohort study	China	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Mortality	Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49161">ChiCTR2000029806</a>	Optimization of treatment and diagnosis plan for critically ill patients	China	Y	Y	Drug Repurposing, Shelved drug or NME	Thymosin, Camrelizumab	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49342">ChiCTR2000029776</a>	A randomized, open-label, blank-controlled, multicenter trial for Polyinosinic-Polycytidylic Acid Injection in the treatment of novel coronavirus pneumonia (COVID-19)	China	N	N	Shelved drug or NME	Polyinosinic-Polycytidylic Acid	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49409">ChiCTR2000029765</a>	A multicenter, randomized controlled trial for the efficacy and safety of tocilizumab in the treatment of new coronavirus pneumonia (COVID-19)	China	Y	N	Drug Repurposing	Tocilizumab	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49297">ChiCTR2000029742</a>	A randomized, parallel controlled trial for the efficacy and safety of Sodium Aescinate Injection in the treatment of patients with pneumonia (COVID-19)	China	Y	N	Shelved drug or NME	Sodium Aescinate	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49263">ChiCTR2000029741</a>	Efficacy of Chloroquine and Lopinavir/ Ritonavir in mild/general novel coronavirus (CoVID-19) infections: a prospective, open-label, multicenter randomized controlled clinical study	China	Y	N	Drug Repurposing	Chloroquine	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49086">ChiCTR2000029656</a>	A randomized, open-label study to evaluate the efficacy and safety of low-dose corticosteroids in hospitalized patients with novel coronavirus pneumonia (COVID-19)	China	Y	N	Drug Repurposing	Methylprednisolone	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49215">ChiCTR2000029636</a>	Efficacy and safety of aerosol inhalation of vMIP in the treatment of novel coronavirus pneumonia (COVID-19): a single arm clinical trial	China	N	N	Shelved drug or NME	vMIP	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49145">ChiCTR2000029609</a>	A prospective, open-label, multiple-center study for the efficacy of chloroquine phosphate in hospitalized patients with novel coronavirus pneumonia (COVID-19)	China	Y	Y	Drug Repurposing	Chloroquine, Lopinavir/ritonavir	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49146">ChiCTR2000029606</a>	Clinical Study for Human Menstrual Blood-derived Stem Cells in the Treatment of Acute Novel Coronavirus Pneumonia (COVID-19)	China	Y	N	Cell/Blood based	ND:MSC	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49042">ChiCTR2000029600</a>	Clinical study on safety and efficacy of Favipiravir in the treatment of novel coronavirus pneumonia (COVID-19)	China	Y	Y	Drug Repurposing	Favipiravir, Lopinavir/ritonavir, Interferon alpha	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49062">ChiCTR2000029569</a>	Safety and efficacy of umbilical cord blood mononuclear cells conditioned medium in the treatment of severe and critically novel coronavirus pneumonia (COVID-19): a randomized controlled trial	China	Y	N	Shelved drug or NME	ND:MSC	Efficacy - Other efficacy	Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=48880">ChiCTR2000029559</a>	Therapeutic effect of hydroxychloroquine on novel coronavirus pneumonia (COVID-19)	China	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49013">ChiCTR2000029544</a>	A randomized controlled trial for the efficacy and safety of Baloxavir Marboxil, Favipiravir tablets in novel coronavirus pneumonia (COVID-19) patients who are still positive on virus detection under the current antiviral therapy	China	Y	Y	Drug Repurposing	Baloxavir Marboxil, Favipiravir	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=48968">ChiCTR2000029542</a>	A prospective cohort study for the efficacy and safety of chloroquine in hospitalized patients with novel coronavirus pneumonia (COVID-19)	China	Y	N	Drug Repurposing	Chloroquine	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=48992">ChiCTR2000029541</a>	A randomised, open, controlled trial for darunavir/cobicistat or Lopinavir/ritonavir combined with thymosin a1 in the treatment of novel coronavirus pneumonia (COVID-19)	China	Y	N	Drug Repurposing	Darunavir, Cobicistat, Lopinavir/ritonavir, Thymosin alpha	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=48991">ChiCTR2000029539</a>	A randomized, open-label study to evaluate the efficacy and safety of Lopinavir-Ritonavir in patients with mild novel coronavirus pneumonia (COVID-19)	China	Y	N	Drug Repurposing	Lopinavir/ritonavir	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=48919">ChiCTR2000029468</a>	The early use of lopinavir/litonavir (LPV/r) and emtritabine (FTC)/ Tenofovir alafenamide Fumarate tablets (TAF) regimen in the treatment of the novel coronavirus pneumonia (COVID-19): a real-world study	China	Y	N	Drug Repurposing	Lopinavir/ritonavir, Emtricitabine, Tenofovir alafenamide	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=50059">ChiCTR2000030179</a>	Experimental study of novel coronavirus pneumonia rehabilitation plasma therapy severe novel coronavirus pneumonia (COVID-19)	China	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49229">ChiCTR2000030173</a>	Key techniques of umbilical cord mesenchymal stem cells for the treatment of novel coronavirus pneumonia (COVID-19) and clinical application demonstration	China	Y	N	Cell/Blood based	ND:MSC	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=50017">ChiCTR2000030170</a>	Study for safety and efficacy of Jakotinib hydrochloride tablets in the treatment severe and acute exacerbation patients of novel coronavirus pneumonia (COVID-19)	China	N	N	Shelved drug or NME	Jaktinib	Safety	Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49567">ChiCTR2000030167</a>	Clinical Trial for Recombinant Human Interleukin-2 in the Treatment of Novel Coronavirus Pneumonia (COVID-19)	China	Y	N	Drug Repurposing	recombinant human IL-2	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=50004">ChiCTR2000030138</a>	Clinical Trial for Human Mesenchymal Stem Cells in the Treatment of Severe Novel Coronavirus Pneumonia (COVID-19)	China	Y	N	Shelved drug or NME	ND:MSC	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49901">ChiCTR2000030116</a>	Safety and effectiveness of human umbilical cord mesenchymal stem cells in the treatment of acute respiratory distress syndrome of severe novel coronavirus pneumonia (COVID-19)	China	N	N	Cell/Blood based	ND:MSC	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49988">ChiCTR2000030113</a>	Clinical study for safety and efficacy of Favipiravir in the treatment of novel coronavirus pneumonia (COVID-19) with poorly responsive ritonavir/ritonavir	China	Y	N	Drug Repurposing	Favipiravir	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49889">ChiCTR2000030089</a>	A randomized, open-label, controlled trial for the efficacy and safety of  Adalimumab Injection in the treatment of patients with severe novel coronavirus pneumonia (COVID-19)	China	Y	N	Drug Repurposing	Adalimumab	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49902">ChiCTR2000030088</a>	Umbilical cord Wharton's Jelly derived mesenchymal stem cells in the treatment of severe novel coronavirus pneumonia (COVID-19)	China	Y	N	Cell/Blood based	ND:MSC	Efficacy - Viral load	Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49831">ChiCTR2000030058</a>	A multicenter, randomized, double-blind, controlled clinical trial for leflunomide in the treatment of novel coronavirus pneumonia (COVID-19)	China	Y	N	Drug Repurposing	Leflunomide	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49869">ChiCTR2000030054</a>	An open randomized controlled trial for Chloroquine phosphate and Hydroxychloroquine sulfate in the treatment of mild and common novel coronavirus pneumonia (COVID-19)	China	Y	Y	Drug Repurposing	Chloroquine, Hydroxychloroquine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49861">ChiCTR2000030046</a>	A single arm trial to evaluate the efficacy and safety of anti-2019-nCoV inactivated convalescent plasma in the treatment of novel coronavirus pneumonia patient (COVID-19)	China	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49891">ChiCTR2000030041</a>	A single-arm, single-center clinical trial for Azivudine tablets in the treatment of adult novel coronavirus pneumonia (COVID-19)	China	N	N	Shelved drug or NME	Azvudine	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49544">ChiCTR2000030039</a>	Clinical study for infusing convalescent plasma to treat patients with new coronavirus pneumonia (COVID-19)	China	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49824">ChiCTR2000030029</a>	A multi-center study on the efficacy and safety of suramin sodium in adult patients with novel coronavirus pneumonia (COVID-19)	China	N	N	Drug Repurposing	Suramin	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49812">ChiCTR2000030020</a>	The clinical application and basic research related to mesenchymal stem cells to treat novel coronavirus pneumonia (COVID-19)	China	N	N	Shelved drug or NME	ND:MSC	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49799">ChiCTR2000030016</a>	Efficacy evaluation of inhalation of mycobacterium vaccae injection for treating Novel coronavirus pneumonia (COVID-19) and the mechanism study of prevention and treatment of respiratory virus infection	China	Y	N	Shelved drug or NME	ND:Mycobacterium	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49777">ChiCTR2000030010</a>	A randomized, double-blind, parallel-controlled, trial to evaluate the efficacy and safety of anti-SARS-CoV-2 virus inactivated plasma in the treatment of severe novel coronavirus pneumonia patients (COVID-19)	China	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49619">ChiCTR2000030007</a>	Multicenter randomized controlled trial for rhG-CSF in the treatment of novel coronavirus pneumonia (COVID-19)	China	Y	N	Cell/Blood based	G-CSF	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49738">ChiCTR2000030002</a>	Clinical study for novel NLRP Inflammasome inhibitor (Tranilast) in the treatment of novel coronavirus (COVID-19)	China	Y	N	Drug Repurposing	Tranilast	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49723">ChiCTR2000030001</a>	The efficacy and safety of Triazavirin for 2019 novel coronary pneumonia (COVID-19): a multicenter, randomized, double blinded, placebo-controlled trial	China	Y	N	Shelved drug or NME	Triazavirin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49510">ChiCTR2000029996</a>	A randomized, open-label, controlled trial for the efficacy and safety of Farpiravir Tablets in the treatment of patients with novel coronavirus pneumonia (COVID-19)	China	Y	N	Drug Repurposing	Favipiravir	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49674">ChiCTR2000029990</a>	Clinical trials of mesenchymal stem cells for the treatment of pneumonitis caused by novel coronavirus (COVID-19)	China	Y	N	Shelved drug or NME	ND:MSC	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49720">ChiCTR2000029989</a>	A randomized controlled Trial for therapeutic efficacy of Recombinant Human Interferon alpha 1b Eye Drops in the treatment of elderly with novel coronavirus pneumonia (COVID-19)	China	Y	N	Drug Repurposing	Interferon alpha 1b	Efficacy - Oxygen parameters	Other	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49218">ChiCTR2000029988</a>	Clinical Study of Chloroquine Phosphate in the Treatment of Severe Novel Coronavirus Pneumonia (COVID-19)	China	Y	N	Drug Repurposing	Chloroquine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49534">ChiCTR2000029851</a>	A multicenter, randomized controlled trial for the efficacy and safety of Alpha lipoic acid (iv) in the treatment of patients of severe novel coronavirus pneumonia (COVID-19)	China	Y	N	Drug Repurposing	Alpha Lipoic Acid	Efficacy - Other efficacy	Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49428">ChiCTR2000029803</a>	A prospective, randomized, open-label, controlled clinical study to evaluate the preventive effect of hydroxychloroquine on close contacts after exposure to the Novel Coronavirus Pneumonia (COVID-19)	China	Y	N	Drug Repurposing	Hydroxychloroquine, Umifenovir	Efficacy - Infection rate (prevention)	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49317">ChiCTR2000029740</a>	Efficacy of therapeutic effects of hydroxycholoroquine in novel coronavirus pneumonia (COVID-19) patients(randomized open-label control clinical trial)	China	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=50380">ChiCTR2000030442</a>	The therapeutic efficacy of combination of Tocilizumab, IVIG and CRRT in sever patients with novel coronavirus pneumonia (COVID-19)	China	N	N	Drug Repurposing, Cell/Blood based	Tocilizumab	Efficacy - Other efficacy	Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=50174">ChiCTR2000030424</a>	A single-center, single-arm clinical trial for azvudine in the treatment of novel coronavirus pneumonia (COVID-19)	China	N	N	Shelved drug or NME	Azvudine	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=50173">ChiCTR2000030398</a>	A randomized, double-blind, placebo-controlled trial for evaluation of  the efficacy and safety of bismuth potassium citrate capsules in the treatment of patients with novel coronavirus pneumonia (COVID-19)	China	Y	N	Drug Repurposing	Bismuth potassium citrate	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49691">ChiCTR2000030265</a>	Clinical research program of continuous renal replacement therapy with adsorption filter for the treatment of the novel coronavirus pneumonia (COVID-19)	China	Y	N	Cell/Blood based	ND:Continuous renal replacement therapy	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49963">ChiCTR2000030261</a>	A study for the key technology of mesenchymal stem cells exosomes atomization in the treatment of novel coronavirus pneumonia (COVID-19)	China	Y	N	Cell/Blood based	ND:MSC	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49883">ChiCTR2000030196</a>	A multicenter, single arm, open label trial for the efficacy and safety of CMAB806 in the treatment of cytokine release syndrome of novel coronavirus pneumonia (COVID-19)	China	N	N	Drug Repurposing	Tocilizumab	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49796">ChiCTR2000030013</a>	A study on the efficacy and safety of recombinant human interferon alpha 1b spray in preventing novel coronavirus (COVID-19) infection in highly exposed medical staffs.	China	Y	N	Drug Repurposing	Interferon alpha 1b	Safety	Exposed individuals (family members, HCP)	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49592">ChiCTR2000029975</a>	Single arm study for exploration of chloroquine phosphate aerosol inhalation in the treatment of novel coronavirus pneumonia (COVID-19)	China	N	N	Drug Repurposing	Chloroquine	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49536">ChiCTR2000029899</a>	Evaluation the Efficacy and Safety of Hydroxychloroquine Sulfate in Comparison with Phosphate Chloroquine in Mild and Commen Patients with Novel Coronavirus Pneumonia (COVID-19): a Randomized, Open-label, Parallel, Controlled Trial	China	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49482">ChiCTR2000029898</a>	Evaluation the Efficacy and Safety of Hydroxychloroquine Sulfate in Comparison with Phosphate Chloroquine in Severe Patients with Novel Coronavirus Pneumonia (COVID-19): a Randomized, Open-Label, Parallel, Controlled Trial	China	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49404">ChiCTR2000029762</a>	A randomized, open-label, controlled trial for the efficacy and safety of hydroxychloroquine sulfate tablets in the treatment of patients with severe novel coronavirus pneumonia (COVID-19)	China	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Viral load	Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49400">ChiCTR2000029761</a>	Multicenter, randomized, open clinical study of Hydroxychloroquine Sulfate tablets in the treatment of common patients with novel coronavirus pneumonia (COVID-19)	China	Y	Y	Drug Repurposing	Hydroxychloroquine	Efficacy - Viral load	Mild/Moderate Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49369">ChiCTR2000029760</a>	A randomized controlled study to evaluate the efficacy and safety of hydroxychloroquine for mild and moderate COVID-19 Infectious diseases	China	Y	N	Drug Repurposing	Hydroxychloroquine, Lopinavir/ritonavir	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=48782">ChiCTR2000029387</a>	Comparative effectiveness and safety of ribavirin plus interferon-alpha, lopinavir/ritonavir plus interferon-alpha and ribavirin plus lopinavir/ritonavir plus interferon-alphain in patients with mild to moderate novel coronavirus pneumonia	China	Y	Y	Drug Repurposing	Ribavirin, Interferon alpha, Lopinavir/ritonavir	Efficacy - Viral load	Mild/Moderate Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=48777">ChiCTR2000029386</a>	A study on treatment strategies of novel coronavirus pnueumonia patients	China	Y	N	Drug Repurposing	Methylprednisolone	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=50727">ChiCTR2000030627</a>	Study on the application of convalescent plasma therapy in severe COVID-19	China	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Viral load	Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49790">ChiCTR2000030535</a>	Multi-Center Clinical Study on the Treatment of Patients with Novel Coronavirus Pneumonia (COVID-19) by Ebastine	China	Y	N	Drug Repurposing	Ebastine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=50507">ChiCTR2000030487</a>	A single-center, single-arm clinical trial for azvudine in the treatment of novel coronavirus pneumonia (COVID-19)	China	N	N	Shelved drug or NME	Azvudine	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=50263">ChiCTR2000030484</a>	HUMSCs and Exosomes Treating Patients with Lung Injury following Novel Coronavirus Pneumonia (COVID-19)	China	Y	N	Cell/Blood based	ND:MSC	Efficacy - Oxygen parameters	Other	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49753">ChiCTR2000030472</a>	An open and controlled clinical study to evaluate the efficacy and safety of Ganovo combined with ritonavir in the treatment of novel coronavirus pneumonia (COVID-19)	China	Y	N	Drug Repurposing, Shelved drug or NME	Danoprevir, Ritonavir	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=50421">ChiCTR2000030471</a>	Efficacy and safety of lipoic acid injection in reducing the risk of progression in common patients with novel coronavirus pneumonia (COVID-19)	China	Y	N	Drug Repurposing	Alpha Lipoic Acid	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=50258">ChiCTR2000030312</a>	A single-center, open-label and single arm trial to evaluate the efficacy and safety of anti-SARS-CoV-2 inactivated convalescent plasma in the treatment of novel coronavirus pneumonia (COVID-19) patient	China	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49081">ChiCTR2000029757</a>	Convalescent plasma for the treatment of severe and critical novel coronavirus pneumonia (COVID-19): a prospective randomized controlled trial	China	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49088">ChiCTR2000029580</a>	Severe novel coronavirus pneumonia (COVID-19) patients treated with ruxolitinib in combination with mesenchymal stem cells: a prospective, single blind, randomized controlled clinical trial	China	Y	N	Drug Repurposing, Cell/Blood based	Ruxolitinib, ND:MSC	Safety	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=48684">ChiCTR2000029308</a>	A randomized, controlled open-label trial to evaluate the efficacy and safety of lopinavir-ritonavir in hospitalized patients with 2019-nCoV infection	China	Y	N	Drug Repurposing	Lopinavir/ritonavir	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=51118">ChiCTR2000030892</a>	Efficacy and Safety of Pirfenidone in the Treatment of Severe Post-Novel Coronavirus Pneumonia (COVID-19)) Fibrosis:a prospective exploratory experimental medical study	China	Y	N	Drug Repurposing	Pirfenidone	Efficacy - Other efficacy	Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=51081">ChiCTR2000030853</a>	Evaluation of the protective effect of dexmedetomidine on patients with severe new coronavirus pneumonia	China	N	N	Drug Repurposing	Dexmedetomidine	Efficacy - Other efficacy	Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=51072">ChiCTR2000030841</a>	Treatment of Acute Severe COVID-19 With Immunoglobulin From Cured COVID-19 Patients	China	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=51050">ChiCTR2000030835</a>	Clinical study on the efficacy of Mesenchymal stem cells (MSC) in the treatment of severe novel coronavirus pneumonia (COVID-19)	China	Y	N	Cell/Blood based	ND:MSC	Efficacy - Other efficacy	Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=50973">ChiCTR2000030779</a>	A randomized, open-label, controlled trial for the efficacy and safety of  Ulinastatin Injection in the treatment of patients with severe novel coronavirus pneumonia (COVID-19)	China	Y	N	Shelved drug or NME	Ulinastatin	Efficacy - Oxygen parameters	Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=50843">ChiCTR2000030718</a>	Clinical Study of Chloroquine Phosphate in the Treatment of 2019-nCoV Infection	China	Y	N	Drug Repurposing	Chloroquine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=50251">ChiCTR2000030703</a>	A randomized, blinded, controlled, multicenter clinical trial to evaluate the efficacy and safety of Ixekizumab combined with conventional antiviral drugs in patients with novel coronavirus pneumonia (COVID-19)	China	Y	N	Drug Repurposing	Ixekizumab	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=50537">ChiCTR2000030702</a>	Convalescent plasma for the treatment of common COVID-19: a prospective randomized controlled trial	China	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=50795">ChiCTR2000030701</a>	A randomized, parallel controlled open-label trial to evaluate the efficacy and safety of Prolongin (Enoxaparin Sodium Injection) in adult hospitalized patients with novel coronavirus pneumonia (COVID-19)	China	Y	N	Drug Repurposing	Enoxaparin	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=50786">ChiCTR2000030700</a>	An evaluative clinical study: efficacy and safety of of Prolongin (Enoxaparin Sodium Injection) in treatment of hospitalized adult patients with common novel coronavirus pneumonia (COVID-19)	China	Y	N	Drug Repurposing	Enoxaparin	Efficacy - Viral load	Mild/Moderate Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=50693">ChiCTR2000030580</a>	Tozumab combined with adamumab(Qletli) in the treatment of severe and critically ill patients with novel coronavirus pneumonia (COVID-19):A prospective, single-center, randomized, parallel controlled trial	China	Y	N	Drug Repurposing	Adalimumab, Tocilizumab	Efficacy - Other efficacy	Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49956">ChiCTR2000030509</a>	Clinical Study of NK Cells in the Treatment of Novel Coronavirus Pneumonia (COVID-19)	China	Y	N	Cell/Blood based	ND:NK cells	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=50279">ChiCTR2000030417</a>	Efficacy and safety of chloroquine phosphate inhalation combined with standard therapy in the treatment of novel coronavirus pneumonia (COVID-19)	China	Y	N	Drug Repurposing	Chloroquine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=50290">ChiCTR2000030381</a>	A randomized, open-label, controlled and single-center trial to evaluate the efficacy and safety of anti-SARS-CoV-2 inactivated convalescent plasma in the treatment of novel coronavirus pneumonia (COVID-19) patient	China	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49779">ChiCTR2000030329</a>	Clinical trial for umbilical cord blood CIK and NK cells in the treatment of mild and general patients infected with novel coronavirus pneumonia (COVID-19)	China	Y	N	Cell/Blood based	ND:Umbilical cord NK/CIK cells	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=50057">ChiCTR2000030187</a>	Efficacy and safety of Lopinavir and Ritonavir in the treatment of novel coronavirus pneumonia (COVID-19)	China	Y	N	Drug Repurposing	Lopinavir/ritonavir	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=50002">ChiCTR2000030135</a>	A randomized controlled trial for high-dose Vitamin C in the treatment of severe and critical novel coronavirus pneumonia (COVID-19) patients	China	Y	N	Drug Repurposing	Ascorbic acid	Efficacy - Mortality	Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49915">ChiCTR2000030082</a>	Randomized controlled trial for the efficacy of dihydroartemisinine piperaquine in the treatment of mild/common novel coronavirus pneumonia (COVID-19)	China	Y	N	Drug Repurposing	Dihydroartemisinin/piperaquine	Efficacy - Viral load	Mild/Moderate Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49806">ChiCTR2000030031</a>	A randomized, double-blind, parallel, controlled trial for comparison of phosphoric chloroquine combined with standard therapy and standard therapy in mild/common patients with novel coronavirus pneumonia (COVID-19)	China	Y	N	Drug Repurposing	Chloroquine	Efficacy - Viral load	Mild/Moderate Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49712">ChiCTR2000029984</a>	Study on the effect of human placenta biological preparation on the defense of immune function against novel coronavirus pneumonia (COVID-19)	China	Y	N	Cell/Blood based	ND:Human placenta extract	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49569">ChiCTR2000029895</a>	Single arm study for the efficacy and safety of GD31 in patients with novel coronavirus pneumonia (COVID-19)	China	N	N	Shelved drug or NME	GD31	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49495">ChiCTR2000029837</a>	A randomized, double-blind, parallel, controlled trial for comparison of phosphoric chloroquine combined with standard therapy and standard therapy in mild/common patients with novel coronavirus pneumon (COVID-19)ia	China	Y	N	Drug Repurposing	Chloroquine	Efficacy - Viral load	Mild/Moderate Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49481">ChiCTR2000029826</a>	A randomized, double-blind, parallel, controlled trial for comparison of phosphoric chloroquine combined with standard therapy and standard therapy in serious/critically ill patients with novel coronavirus pneumonia (COVID-19)	China	Y	N	Drug Repurposing	Chloroquine	Efficacy - Mortality	Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49384">ChiCTR2000029817</a>	Clinical Study of Cord Blood NK Cells Combined with Cord Blood Mesenchymal Stem Cells in the Treatment of Acute Novel Coronavirus Pneumonia (COVID-19)	China	Y	N	Cell/Blood based	ND:MSC, ND:NK cells	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49374">ChiCTR2000029812</a>	Clinical Study for Umbilical Cord Blood Mononuclear Cells in the Treatment of Acute Novel Coronavirus Pneumonia (NCP)	China	Y	N	Cell/Blood based	ND:Cord blood MNC	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=51404">ChiCTR2000031139</a>	Safety and Effectiveness of Human embryonic stem cell-derived M cells (CAStem) for Pulmonary Fibrosis Correlated with novel coronavirus pneumonia(COVID-19)	China	N	N	Cell/Blood based	ND:MSC	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=51416">ChiCTR2000031138</a>	Prospective exploratory clinical research on the efficacy and safety of pirfenidone capsules in the treatment of severe novel coronavirus pneumonia (COVID-19)	China	Y	N	Drug Repurposing	Pirfenidone	Efficacy - Other efficacy	Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=51329">ChiCTR2000030987</a>	Clinical Trial of Favipiravir Tablets Combine With Chloroquine Phosphate in the Treatment of novel coronavirus pneumonia (COVID-19)	China	Y	N	Drug Repurposing	Chloroquine, Favipiravir	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=50199">ChiCTR2000030944</a>	An open, multi-center, control, exploratory clinical study of human NK cells and UC-MSCs transplantation for severe novel coronavirus pneumonia	China	Y	N	Cell/Blood based	ND:NK cells, ND:MSC	Efficacy - Other efficacy	Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=51059">ChiCTR2000030939</a>	Preliminary evaluation of the safety and efficacy of oral LL-37 antiviral peptide (CAS001) in the treatment of novel coronavirus pneumonia	China	N	N	Shelved drug or NME	CSA0001	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=50696">ChiCTR2000030929</a>	A randomized, double-blind, parallel-controlled trial to evaluate the efficacy and safety of anti-SARS-CoV-2 virus inactivated plasma in the treatment of severe novel coronavirus pneumonia (COVID-19)	China	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=51141">ChiCTR2000030922</a>	Prospective, open-label, controlled, multicenter cohort study of long-acting interferon plus ribavirin in patients with COVID-19 infection	China	Y	N	Drug Repurposing	Interferon alpha 2a	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=51154">ChiCTR2000030906</a>	A single-center, open and dose-escalation phase I clinical trial for recombinant novel coronavirus vaccine (adenoviral vector) in healthy adults aged between 18 and 60 years	China	Y	N	Vaccine	Adenoviral vaccine	Safety	General population	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=50660">ChiCTR2000030539</a>	Study for the effect of 3% hydrogen peroxide gargle on the Intraoral novel coronavirus of the patients with novel coronavirus pneumonia (COVID-19)	China	Y	N	Drug Repurposing	Hydrogen peroxide	Efficacy - Viral load	Mild/Moderate Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=50137">ChiCTR2000030254</a>	the Efficacy and Safety of Favipiravir for novel coronavirus   infected pneumonia: A multicenter, randomized, open, positive, parallel-controlled clinical study	China	Y	N	Drug Repurposing	Favipiravir	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49968">ChiCTR2000030224</a>	Clinical study of mesenchymal stem cells in treating severe novel coronavirus pneumonia (COVID-19)	China	Y	N	Cell/Blood based	ND:MSC	Efficacy - Oxygen parameters	Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49524">ChiCTR2000029868</a>	Hydroxychloroquine treating novel coronavirus pneumonia (COVID-19): a randomized controlled, open label, multicenter trial	China	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=48809">ChiCTR2000029496</a>	A randomized, open label, parallel controlled trial for evaluating the efficacy of recombinant cytokine gene-derived protein injection on clearing novel coronavirus in patients with novel coronavirus pneumonia (COVID-19)	China	Y	N	Shelved drug or NME	Novaferon	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49420">ChiCTR2000031204</a>	A multicenter, single-blind, randomized controlled clinical trial for chloroquine phosphate in the treatment of 2019 novel coronavirus-infected pneumonia	China	Y	N	Drug Repurposing	Chloroquine	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=51112">ChiCTR2000031196</a>	Clinical efficacy of novel coronavirus infection treated by combination of interferon regimen and Ritonavir Tablets	China	Y	N	Drug Repurposing	Lopinavir/ritonavir, Interferon	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49840">ChiCTR2000030028</a>	Clinical comparative study of PD-1 mAb in the treatment of severe and critical patients with novel coronavirus disease (COVID-19)	China	Y	N	Drug Repurposing	Anti-PD1 mab (unspecified)	Efficacy - Other efficacy	Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=50474">ChiCTR2000031630</a>	Clinical study for Celebrex in the treatment of novel coronavirus pneumonia (COVID-19)	China	Y	N	Drug Repurposing	Celecoxib	Other	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=50254">ChiCTR2000031501</a>	The efficacy  of convalescent plasma in patients with critical novel coronavirus pneumonia (COVID-19): a pragmatic, prospective cohort study	China	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Mortality	Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=51904">ChiCTR2000031494</a>	Clinical study for stem cells in the treatment of severe novel coronavirus pneumonia (COVID-19)	China	Y	N	Cell/Blood based	ND:MSC	Efficacy - Other efficacy	Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=51693">ChiCTR2000031454</a>	Clinical study for prevention and treatment of digestive tract lesions caused by novel coronavirus pneumonia (COVID-19)	China	Y	N	Drug Repurposing	Rabeprazole	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49254">ChiCTR2000031430</a>	Evaluation of  the safety and efficacy for human umbilical cord mesenchymal stem cells in COVID-19 induced pulmonary fibrosis	China	Y	N	Cell/Blood based	ND:MSC	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://anzctr.org.au/ACTRN12620000454976.aspx">ACTRN12620000454976</a>	High-dose intravenous zinc (HDIVZn) as adjunctive therapy in COVID-19 positive critically ill patients: A pilot randomized controlled trial	Australia	Y	N	Drug Repurposing	Zinc chloride	Efficacy - Oxygen parameters	Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=52006">ChiCTR2000031781</a>	A randomized, double-blinded, placebo-controlled phase II clinical trial for Recombinant Novel Coronavirus (2019-nCOV) Vaccine (Adenovirus Vector) in healthy adults aged above 18 years	China	Y	N	Vaccine	Adenoviral vaccine	Efficacy - Other efficacy	General population	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=50613">ChiCTR2000031735</a>	Clinical study for natural killer (NK) cells from umbilical cord blood in the treatment of viral pneumonia include novel coronavirus pneumonia (COVID-19)	China	Y	N	Cell/Blood based	ND:NK cells	Safety	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=50928">ChiCTR2000030750</a>	A clinical study for effectiveness and safety evaluation for recombinant chimeric COVID-19 epitope DC vaccine in the treatment of novel coronavirus pneumonia	China	Y	N	Vaccine	Chimeric COVID-19 DC vaccine	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=50241">ChiCTR2000030328</a>	Clinical application of inhaled acetylcysteine solution in the treatment of novel coronavirus pneumonia (COVID-19)	China	Y	N	Drug Repurposing	N-acetylcysteine	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://anzctr.org.au/ACTRN12620000473965.aspx">ACTRN12620000473965</a>	Reducing acute severe respiratory events in health care workers during the Covid-19 pandemic with OM85	Australia	Y	N	Drug Repurposing	OM-85	Efficacy - Other efficacy	Exposed individuals (family members, HCP)	
<a href="https://anzctr.org.au/ACTRN12620000478910.aspx">ACTRN12620000478910</a>	Cord Blood Therapy to prevent progression of COVID-19 related pneumonia	Australia	Y	N	Cell/Blood based	ND:Stem cells	Safety	Mild/Moderate Cases	
<a href="https://anzctr.org.au/ACTRN12620000480987.aspx">ACTRN12620000480987</a>	Stress-reduction Using Probiotics to Promote Ongoing Resilience Throughout COVID-19 for Healthcare Workers: A randomised placebo-controlled trial	New Zealand	Y	N	Drug Repurposing	Lactobacillus rhamnosus HN001	Other	Exposed individuals (family members, HCP)	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=50022">ChiCTR2000030300</a>	Umbilical cord mesenchymal stem cells for the treatment of patients at high risk of novel coronavirus pneumonia  (COVID-19): a single-center, prospective, open clinical study	China	N	N	Cell/Blood based	ND:MSC	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/46424">IRCT20200310046736N1</a>	Comparison of The Therapeutic Effect of Convalescent Plasma and Plasma-derived Immunoglobulin-enriched solution on COVID-19 Patients: A Clinical Trial Study	Iran	Y	Y	Cell/Blood based	ND:Convalescent plasma	Efficacy - Other efficacy	Severe Cases	
<a href="http://en.irct.ir/trial/46536">IRCT20100228003449N30</a>	Evaluating efficacy and safety of hydroxychloroquine + lopinavir or atazanavir/ritonavir combination  in patients with COVID-19	Iran	N	N	Drug Repurposing	Hydroxychloroquine, Atazanavir/ritonavir, Lopinavir/ritonavir	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="http://en.irct.ir/trial/46538">IRCT20100228003449N28</a>	Evaluating efficacy and safety of interferone   -1a in the treatment COVID-19 infection	Iran	Y	N	Drug Repurposing	Interferon beta-1a	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="http://en.irct.ir/trial/46545">IRCT20100228003449N27</a>	Evaluating efficacy and safety of interferone   -1b (IFN   -1b) in the treatment of COVID-19	Iran	Y	N	Drug Repurposing	Interferon beta-1b	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="http://en.irct.ir/trial/46561">IRCT20151227025726N12</a>	Evaluting the therapeutic and adverse effects of Interferon beta 1-a subcutaneous administration in patients with novel Coronavirus (COVID-19)	Iran	N	N	Drug Repurposing	Interferon beta-1a	Efficacy - Other efficacy	Severe Cases	
<a href="http://en.irct.ir/trial/46564">IRCT20170117032004N3</a>	evaluation the effect of vitamin A on respiratory signs and hospitalization in patients with COVID-19	Iran	Y	N	Drug Repurposing	Vitamin A	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="http://en.irct.ir/trial/46567">IRCT20100228003449N29</a>	Evaluating efficacy and safety of sofosbuvir/ ledipasvir in  treatment of COVID-19	Iran	Y	N	Drug Repurposing	Ledipasvir/sofosbuvir	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="http://en.irct.ir/trial/46573">IRCT20200317046797N1</a>	Effect of Camostate mesylate on clinical improvement and outcome of  Coronavirus (COVID-19)-induced pneumonia	Iran	Y	N	Drug Repurposing	Camostat	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/46576">IRCT20160625028622N1</a>	The effect of  NOSCOVID on pulmonary & other clinical manifestations of COVID-19 patients	Iran	Y	N	Drug Repurposing	Noscapine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/46603">IRCT20120826010664N6</a>	Effect of hydroxychloroquine on prevention of covid-19 virus infection among treatment staff in Arash hospital-A double-blind clinical trial	Iran	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="http://en.irct.ir/trial/46623">IRCT20140528017891N8</a>	Evaluation of the efficacy and safety of cord-derived mesenchymal stem cell transplantation in the treatment of COVID-19	Iran	N	N	Cell/Blood based	ND:Stem cells	Efficacy - Mortality	Severe Cases	
<a href="http://en.irct.ir/trial/46624">IRCT20200321046828N1</a>	The effect of genetical nanocomposit drug with cell imunity level on human coronavirus (COVID-19)	Iran	Y	Y	Shelved drug or NME	NOS	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/46629">IRCT20190727044343N1</a>	The effect of febuxostat against lung injury induced by COVID-19 virus in infected patients: A clinical trial study	Iran	Y	N	Drug Repurposing	Febuxostat	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="http://en.irct.ir/trial/46665">IRCT20150914024017N1</a>	the efficacy of Interferon beta 1 a (ReciGen)  in treatment of patients with Covid-19 in Sina Hospital Emergency Department	Iran	Y	N	Drug Repurposing	Interferon beta-1a	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/46668">IRCT20140911019125N6</a>	Study the effect of intravenous injection of dental pulp mesenchymal stem cells in treatment of patients with COVID-19 pneumonia	Iran	N	N	Cell/Blood based	ND:Stem cells	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/46681">IRCT20151227025726N13</a>	Evaluation the Efficacy and Safety of Tocilizumab in Patients with Novel Coronavirus (COVID-19)	Iran	N	N	Drug Repurposing	Tocilizumab, Hydroxychloroquine, Oseltamivir, Lopinavir/Ritonavir, Interferon beta-1a	Efficacy - Other efficacy	Severe Cases	
<a href="http://en.irct.ir/trial/46693">IRCT20160310026998N10</a>	Study of the metformin effect on the survival and recovery rate of COVID-19 patients	Iran	Y	N	Drug Repurposing	Metformin	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/46751">IRCT20200324046850N5</a>	Study of the effect of Vitamin C on duration of hospital stay in patients with Covid-19	Iran	Y	N	Drug Repurposing	Ascorbic acid	Efficacy - Other efficacy	Severe Cases	
<a href="http://en.irct.ir/trial/46759">IRCT20200325046860N1</a>	Evaluation of Convalescent Plasma as a Potential Therapy for COVID-19 infected patients	Iran	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/46786">IRCT20200317046797N2</a>	Effect of Fingolimod for treatment of COVID-19-induced cytokine storm	Iran	Y	N	Drug Repurposing	Fingolimod	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="http://en.irct.ir/trial/46789">IRCT20200325046860N2</a>	Mesenchymal stem cell utilization in reducing complications and enhancing pneumonia healing  in patients infected with 2019-nCoV (phase I clinical trial)	Iran	N	N	Cell/Blood based	ND:Stem cells	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/46804">IRCT20190917044805N2</a>	Effects of High-dose Vitamin C on Treatment, Clinical Symptoms and Laboratory Signs of Iranian COVID-19 Patients: A Double Blind Randomized Clinical Trial	Iran	Y	N	Drug Repurposing	Ascorbic acid	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/46810">IRCT20120225009124N4</a>	Efficacy of different methods of administeration of combination regiemn including dexamethasone, IV-IG and Interferone beta for treatment of patients with severe COVID-19: a randomized controlled trial	Iran	Y	Y	Drug Repurposing	Dexamethasone, Interferon beta, ND:Immunoglobulin	Efficacy - Oxygen parameters	Severe Cases	
<a href="http://en.irct.ir/trial/46824">IRCT20180802040678N4</a>	Evaluation of the effects of Losartan in patients with corona virus disease 2019	Iran	Y	N	Drug Repurposing	Losartan	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/46837">IRCT20150704023055N2</a>	To evaluate the effectiveness of hemoperfusion in patients with severe coronavirus disease 2019 (COVID-19)	Iran	N	N	Cell/Blood based	ND:Procedure	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="http://en.irct.ir/trial/46838">IRCT20200319046819N1</a>	Impact of vitamin B, A, D, E, C supplementation on improvement and mortality rate in patients with COVID-19 admitted in intensive care unit	Iran	Y	N	Drug Repurposing, Other	Ascorbic acid, ND:Vitamin supplementation	Efficacy - Other efficacy	Severe Cases	
<a href="https://www.clinicaltrials.jp/user/showCteDetailE.jsp?japicId=JapicCTI-205238">JPRN-JapicCTI-205238</a>	Multicenter, Adaptive, Randomized, Placebo-Controlled, Comparative Study to Evaluate the Efficacy and Safety of Favipiravir in Patients with COVID-19 Non-Severe Pneumonia	Japan	Y	N	Drug Repurposing	Favipiravir	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://anzctr.org.au/ACTRN12620000417987.aspx">ACTRN12620000417987</a>	Multi-Site, Randomized, Open-Label, Parallel-Group, Placebo-Controlled Study to Assess the Chemoprophylactic Efficacy of Chloroquine Against SARS-CoV-2/COVID-19 in Healthcare Workers at High-Risk of Exposure	Australia	Y	N	Drug Repurposing	Chloroquine	Efficacy - Other efficacy	Exposed individuals (family members, HCP)	
<a href="https://anzctr.org.au/ACTRN12620000457943.aspx">ACTRN12620000457943</a>	A Randomised, Double Blind, Placebo-Controlled Trial of the Efficacy of Hydroxychloroquine for the Community-Based Treatment of Adults With Diagnosed COVID-19 	New Zealand	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=52958">ChiCTR2000032400</a>	the efficacy and safety of high dose intravenous vitamin C in the treatment of novel coronavirus pneumonia (COVID-19): a prospective, randomize, controlled trial	China	Y	N	Drug Repurposing	Ascorbic acid	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=52867">ChiCTR2000032314</a>	A randomized clinical trial for the efficacy and safety of Aliskiren and Nifedipine in novel coronavirus pneumonia (COVID-19) patients with hypertension	China	Y	Y	Drug Repurposing	Aliskiren, Nifedipine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases, Other	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=52824">ChiCTR2000032242</a>	A multicenter, randomized, open, controlled trial for the efficacy and safety of oral kolimycin in the treatment of patients with new coronavirus pneumonia (CoVID-19)	China	Y	N	Drug Repurposing	Colistin	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://anzctr.org.au/ACTRN12620000517976.aspx">ACTRN12620000517976</a>	A randomised controlled trial of Nebulised Heparin in critically ill mechanically ventilated patients with COVID-19 to assess the effect on  the  duration of mechanical ventilation.	Australia	Y	N	Drug Repurposing	Heparin	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=52394">ChiCTR2000032487</a>	Study for using sulfate in the prevention and control of novel coronavirus pneumonia (COVID-19) in high and low prevalence communities	China	Y	N	Drug Repurposing	Hydroxychloroquine	Other	General population	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=53003">ChiCTR2000032459</a>	Evaluation of the safety and immunogenicity of inactivated novel coronavirus (2019-CoV) vaccine (Vero cells) in healthy population aged 3 years and above: a randomized, double-blind, placebo parallel-controlled phase I/II clinical trial	China	Y	N	Vaccine	ND:Vaccine	Safety	General population	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=52506">ChiCTR2000032135</a>	Efficacy and Safety of ulinastatin in the Treatment of novel coronavirus pneumonia (COVID-19)	China	Y	Y	Shelved drug or NME	Ulinastatin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=51437">ChiCTR2000031174</a>	Effectiveness and safety of hydroxychloroquine sulfate in the preventive treatment of novel coronavirus pneumonia (COVID-19)	China	Y	N	Drug Repurposing	Hydroxychloroquine	Other	General population	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=53368">ChiCTR2000032769</a>	A randomized,double blinded, parallel  controlled clinical trial for azvudine in the treatment of novel coronavirus pneumonia (COVID-19)	China	Y	N	Shelved drug or NME	Azvudine	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=53322">ChiCTR2000032717</a>	Efficacy and safety of high-dose vitamin C combined with traditional Chinese medicine in the treatment of moderate and severe novel coronavirus pneumonia (COVID-19)	China	Y	Y	Drug Repurposing, TCM	Ascorbic acid, ND:TCM	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=53389">ChiCTR2000032716</a>	High dose intravenous vitamin C might be used as an important rescue therapy for aggravation of severe and critical novel coronavirus pneumonia (COVID-19) patients	China	N	N	Drug Repurposing	Ascorbic acid	Efficacy - Other efficacy	Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=53790">ChiCTR2000033003</a>	A safety and immune response study of novel coronavirus pneumonia (COVID-19) s-vax loaded autologous dendritic cells	China	N	N	Cell/Blood based	ND:Vaccine	Safety	General population	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=53658">ChiCTR2000032915</a>	A randomized controlled trial for the efficacy and safety of artemisinin-pipequine tablets in the treatment of the mild and common type novel coronavirus pneumonia (COVID-19) patients whose nCoV Nucleic acid did not turn negative after treated by hydroxychloroquine and Abidor	China	Y	N	Drug Repurposing	Artemisinin-piperaquine	Safety	Mild/Moderate Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=50136">ChiCTR2000030262</a>	Clinical study of novel coronavirus (SARS-Cov-2) infection treated with aerosol inhalation (IFN-? plus anti-inflammatory factor TFF2)	China	Y	N	Shelved drug or NME	TFF2	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49224">ChiCTR2000029638</a>	A Multicenter, Randomized, Controlled trial for Recombinant Super-Compound Interferon (rSIFN-co) in the Treatment of Novel Coronavirus (2019-nCoV) Pneumonia	China	Y	N	Shelved drug or NME	rSIFN-co	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/46533">IRCT20200314046764N1</a>	The evaluation of pirfenidone effects on prevention and treatment of pulmonary fibrosis and acute respiratory distress syndrome caused by COVID-19	Iran	Y	N	Drug Repurposing	Pirfenidone	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/46550">IRCT20150303021315N17</a>	Evaluation of the safety and efficacy of tocilizumab (AryoGen ?Pharmed Co., Iran) in patients with severe COVID-19?	Iran	N	N	Drug Repurposing	Tocilizumab	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/46551">IRCT20200312046749N1</a>	Evaluation the efficacy of Tumor Necrosis Factor alpha inhibitor in COVID-19 outcomes: a prospective clinical trial study.	Iran	N	N	Drug Repurposing	Etanercept biosimilar	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/46639">IRCT20190727044343N2</a>	Atorvastatin effect in Clinical and Laboratory findings of patiens with COVID-19 admitted RAZI referral hospital in Mazandaran State: A Randomized Clinical Trial	Iran	Y	N	Drug Repurposing	Atorvastatin	Other	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/46660">IRCT20171122037571N2</a>	A single-arm multicenter clinical trial to evaluate the safety and efficacy of Remdesivir in COVID-19 patients with progressive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)	Iran	N	N	Shelved drug or NME	Remdesivir	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/46713">IRCT20200324046850N2</a>	Comparison of the effect of Sofosbuvir + Daclatasvir (Sovodac) and Ribavirin in Covid-19 Patients with Severe Symptoms	Iran	Y	N	Drug Repurposing	Daclatasvir/sofosbuvir	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="http://en.irct.ir/trial/46741">IRCT20190804044429N1</a>	Efficacy and safety evaluation of therapeutic regimen of lopinavir/ritonavir and interferon beta 1b in patients with COVID-19	Iran	Y	N	Drug Repurposing	Interferon beta-1b, Hydroxychloroquine, Lopinavir/ritonavir	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/46776">IRCT20200204046369N1</a>	Evaluation of Methylprednisolone Administration as a Therapeutic Option in the 2019 Novel Coronavirus (COVID-19): A Non-Randomized Controlled Study	Iran	N	N	Drug Repurposing	Methylprednisolone	Efficacy - Oxygen parameters	Severe Cases	
<a href="http://en.irct.ir/trial/46790">IRCT20130812014333N145</a>	Comparative assessment of the efficacy and safety of add ontreatment with    Sofosbuvir plus Velpatasvir    to    standard of care therapeutic regimen    in patients with COVID-19	Iran	Y	N	Drug Repurposing	Sofosbuvir/velpatasvir	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/46811">IRCT20200325046859N1</a>	Evaluation of the efficacy of intravenous immunoglobulin (IVIg) in patients with severe  COVID-19 (Before intubation phase) who have not responded to treatment with the standard three-drug protocol (hydroxychloroquine / chloroquine + lupinavir / ritonavir + ribavirin)	Iran	N	N	Cell/Blood based	ND:Immunoglobulin	Efficacy - Other efficacy	Severe Cases	
<a href="http://en.irct.ir/trial/46814">IRCT20161204031229N3</a>	Study of the Efficacy of Teicoplanin on mortality rate of patients with  COVID-19 Infection: A randomized clinical trial	Iran	Y	N	Drug Repurposing	Teicoplanin	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/46849">IRCT20130917014693N10</a>	Evaluation the efficacy and safety of Hydroxychloroquine administration for COVID-19 post exposure prophylaxis	Iran	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Other efficacy	Exposed individuals (family members, HCP)	
<a href="http://en.irct.ir/trial/46853">IRCT20130812014333N147</a>	Comparative assessment of the efficacy and safety of addon treatment with    Sofosbuvir-Daclatasvir   ,    Lithium   ,and    Trifluoprazine    to    standard of care in three groups of patients with COVID-19	Iran	Y	Y	Drug Repurposing	Sofosbuvir-Daclatasvir, Lithium, Trifluoperazine, Trihexyphenidyl	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/46887">IRCT20131215015805N2</a>	Assessment of effect of levamisole on pneumonia caused by COVID-19	Iran	Y	N	Drug Repurposing	Levamisole	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="http://en.irct.ir/trial/46926">IRCT20200403046926N1</a>	The effect of adding SOVODAK (sofosbuvir+daclatasvir) to the treatment protocol of COVID-19 outpatients: A Clinical Trial Study	Iran	Y	N	Drug Repurposing	Sofosbuvir/daclatasvir	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/46931">IRCT20151228025732N53</a>	Evaluation of the therapeutic effects of Convalescent Plasma (CP) of recovered people from Covid-19 in improving clinical and laboratory symptoms of hospitalized patients	Iran	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Oxygen parameters	Severe Cases	
<a href="http://en.irct.ir/trial/46932">IRCT20130306012728N8</a>	Prospective post-exposure hydroxycloroquine prophylaxis for Covid 19 (PROSCLOROCOV 19)	Iran	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="http://en.irct.ir/trial/46942">IRCT20151227025726N14</a>	Evaluation the efficacy and safety of Favipiravir made by Shahid Beheshti University of Medical Sciences in comparison with Lopinavir-ritonavir in COVID-19 patients	Iran	Y	N	Drug Repurposing	Favipiravir	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/46946">IRCT20200405046958N1</a>	Effect of Hydroxychloroquine on Novel Coronavirus Disease (COVID-19) prevention in cancer patients under treatment	Iran	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Other	
<a href="http://en.irct.ir/trial/46968">IRCT20200318046812N2</a>	Safety and efficacy of    Hydroxychloroquine + Azithromycin + Naproxen + Prednisolone    and    Hydroxychloroquine + Azithromycin + Naproxen    regimens in comparison with    Hydroxychloroquine + kaletra    on the need for intensive care unit treatment in patients with COVID-19; a randomized, multicenter, parallel groups, open label study	Iran	Y	N	Drug Repurposing	Prednisolone	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/46969">IRCT20200317046797N4</a>	Effect of Bromhexine Hydrochloride on clinical improvement and outcome of  COVID-19-induced pneumonia	Iran	Y	N	Drug Repurposing	Bromhexine	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="http://en.irct.ir/trial/46973">IRCT20200404046948N1</a>	Randomized, parallel-controlled and multi-center clinical study evaluating the efficacy and safety of convalescent  plasma, in the treatment of patients with severe SARS-CoV-2 infection (COVID-19)	Iran	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - WHO scale	Severe Cases	
<a href="http://en.irct.ir/trial/46974">IRCT20180520039738N2</a>	Comparison of the effectiveness of standard treatment with stand treatment plus Vitamin A in treatment in covid19 patients	Iran	Y	N	Drug Repurposing	Vitamin A	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/46977">IRCT20081019001369N4</a>	Clinical trial of minocycline against COVID-19	Iran	Y	N	Drug Repurposing	Minocycline	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47006">IRCT20200408046992N1</a>	Evaluation of the Effect  of  Trifluoperazin in Treatment of   Patients with Confirmed 2019 Novel Coronavirus(COVID- 19): An Open-Label Randomized Clinical Trial	Iran	Y	N	Drug Repurposing	Trifluoperazine	Efficacy - WHO scale	Severe Cases	
<a href="http://en.irct.ir/trial/47012">IRCT20200408046987N1</a>	Dose-Finding study of Ivermectin treatment on patients infected with Covid-19:A clinical trial	Iran	Y	N	Drug Repurposing	Ivermectin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47014">IRCT20200317046797N3</a>	To evaluate the effectiveness of intravenous immunoglobulin (IVIG) for the treatment of COVID-19-induced cytokine storm	Iran	Y	N	Cell/Blood based	ND:Immunoglobulin	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="http://en.irct.ir/trial/47021">IRCT20200406046968N1</a>	The  effect of IL-6 inhibitor (Tocilizumab) on the prognosis of covid-19 patients with acute respiratory failure	Iran	N	N	Drug Repurposing	Tocilizumab	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47022">IRCT20150808023559N20</a>	Evaluation of safety and efficacy of hydroxychloroquine plus favipiravir drug regimen in comparison with hydroxychloroquine plus kaletra in  hospitalized patients with COVID-19	Iran	Y	N	Drug Repurposing	Favipiravir	Efficacy - Mortality	Severe Cases	
<a href="http://en.irct.ir/trial/47052">IRCT20200410047009N1</a>	Evaluation of the role of naproxen as adjunctive therapy with standard therapies and its efficacy in the early improvement and reduced mortality rate of COVID-19 patients	Iran	Y	N	Drug Repurposing	Naproxen	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47058">IRCT20200409047007N1</a>	The effect of plasma administration of COVID-19 survivors in patients with acute respiratory distress syndrome due to COVID-19	Iran	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Mortality	Mild/Moderate Cases, Other	
<a href="http://en.irct.ir/trial/47073">IRCT20200217046526N2</a>	Mesenchymal Stem Cell Therapy for Acute Respiratory Distress Syndrome in Coronavirus Infection: A Phase 2-3 Clinical Trial	Iran	Y	N	Cell/Blood based	ND:Stem cells	Safety	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47078">IRCT20200411047025N1</a>	Evaluation of effectiveness? of Intravenous vitamin c in Patients with COVID-19 Referred to Imam ?Khomeini Hospital: a clinical trial ?	Iran	Y	N	Drug Repurposing	Ascorbic acid	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47087">IRCT20080901001165N46</a>	Investigating the efficacy and safety of Umifenovir in controlling the symptoms of patients with COVID-19	Iran	Y	N	Drug Repurposing	Umifenovir	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47088">IRCT20200406046963N1</a>	Evaluation of the efficacy and safety of methylprednisolone pulse therapy in treatment of Covid-19 patients with ARDS	Iran	Y	N	Drug Repurposing	Methylprednisolone	Efficacy - Mortality	Severe Cases	
<a href="http://en.irct.ir/trial/47090">IRCT20190122042450N4</a>	Prevention of COVID-19 disease after contact with an infected patient with coronavirus after taking hydroxychloroquine in the community	Iran	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Other efficacy	Exposed individuals (family members, HCP)	
<a href="http://en.irct.ir/trial/47099">IRCT20200411047030N1</a>	Evaluation of adding melatonin to routine treatment on outcomes and quality of sleep in COVID-19 patients	Iran	N	N	Drug Repurposing	Melatonin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47110">IRCT20190717044241N2</a>	Cell therapy in patients with coronavirus19 using mesenchymal stem cells	Iran	N	N	Cell/Blood based	ND:Stem cells	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47115">IRCT20200406046968N2</a>	Efficacy of convalescent plasma transfusion of COVID-19 survivors on the treatment of respiratory failure of these patients	Iran	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Viral load	Severe Cases	
<a href="http://en.irct.ir/trial/47119">IRCT20170207032444N3</a>	The efficacy and safety of Thalidomide in severe Covid19 pneumonia: Arandomized controlled clinical trial	Iran	Y	N	Drug Repurposing	Thalidomide	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="http://en.irct.ir/trial/47141">IRCT20081019001369N5</a>	Clinical trial of lithium in improving the clinical and laboratory symptoms of patients with COVID-19	Iran	Y	N	Drug Repurposing	Lithium	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47142">IRCT20200408046988N1</a>	Evaluation of the efficacy of melatonin tablets as auxiliary medication in accelerating the improvement of the COVID-19 symptoms and clinical findings: A double-blind randomized and placebo controlled trial	Iran	Y	N	Drug Repurposing	Melatonin	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47146">IRCT20200413047062N1</a>	Evaluating the efficacy of Atorvastatin in clinical improvement, prognosis and hospitalization course in patients with COVID-19 infection	Iran	Y	N	Drug Repurposing	Atorvastatin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47152">IRCT20200406046968N3</a>	effect of Interfron-beta1(zifron) on clinical improvement and prognosis of COVID-19 in Tabriz Imam-Reza hospital	Iran	Y	N	Drug Repurposing	Interferon beta-1b	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47156">IRCT20200413047063N1</a>	Placental Mesenchymal Stem cells for treatment of ARDS in Coronavirus infection, Phase 1 and 2 Clinical Trials	Iran	Y	N	Cell/Blood based	ND:Stem cells	Safety	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47169">IRCT20200414047070N1</a>	Determining the effect of skin test  purified protein derivative (PPD) on the recovery process of patients with COVID 19 in patients with this disease	Iran	Y	N	Cell/Blood based	ND:Purified protein derivative	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47173">IRCT20170210032478N3</a>	The efficacy of inhaled formoterol on symptom improvement  in covid 19 patients	Iran	Y	N	Drug Repurposing	Formoterol	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47212">IRCT20200413047056N1</a>	Comparison between the efficacy of intravenous immunoglobulin and convalescent plasma in improving the condition of patients with COVID-19: A randomized clinical trial	Iran	Y	N	Cell/Blood based	ND:Immunoglobulin, ND:Convalescent plasma	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47219">IRCT20200418047116N1</a>	Effect of Intravenous immunoglobulin (IVIG) versus Kaletra (lopinavir and ritonavir) tablets in patients with acute respiratory infection (COVID-19): A clinical trial studies	Iran	N	N	Cell/Blood based	ND:Immunoglobulin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47244">IRCT20200415047092N1</a>	Safety and Effectiveness of azithromycin in Patients with COVID-19 Referred to zeiaeian Hospital : A clinical trial study	Iran	Y	N	Drug Repurposing	Azithromycin	Efficacy - Other efficacy	Severe Cases	
<a href="http://en.irct.ir/trial/47264">IRCT20200417047113N1</a>	Evaluating the safety and efficacy of allogeneic NK cells on COVID-19 induced pneumonia, double blind, randomized clinical trial	Iran	Y	Y	Cell/Blood based	ND:NK-cells	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47265">IRCT20200419047128N1</a>	Assessment of the effect of Tranilast on the efficacy of antiviral drug regimens in the treatment of patients with severe COVID19	Iran	Y	N	Drug Repurposing	Tranilast	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="http://en.irct.ir/trial/47266">IRCT20200416047099N1</a>	Use of convalescent plasma in the treatment of patients with severe COVID-19 pneumonia	Iran	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Other efficacy	Severe Cases	
<a href="http://en.irct.ir/trial/47268">IRCT20200418047122N1</a>	Evaluation of the protective effect of a combination drug including Apocynin, Niacin, and Tannin on prevention of cardiovascular and respiratory morbidities and mortality in COVID-19 infection: A Clinical Trial	Iran	Y	N	Drug Repurposing	Niacin-Tannin, Apocynin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="http://en.irct.ir/trial/47275">IRCT20200418047121N2</a>	Investigation the adipose and placenta-derived mesenchymal stem cells effect on the respiratory distress syndrome in patients with COVID-19: a pilot study	Iran	N	N	Cell/Blood based	ND:Stem cells	Efficacy - Infection rate (prevention)	Mild/Moderate Cases	
<a href="http://en.irct.ir/trial/47300">IRCT20200329046892N1</a>	Evaluation of Trifluoperazine Effectiveness in Treatment Process, Survival rate and Cure rate of COVID-19 Patients	Iran	Y	N	Drug Repurposing	Trifluoperazine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47319">IRCT20151222025660N2</a>	The prophylactic effect of Hydroxychloroquine on Novel Corona virus (COVID-19) in health care providers	Iran	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="http://en.irct.ir/trial/47334">IRCT20200420047147N1</a>	Evaluation the efficacy and safety of Sitagliptin administration in patients with COVID-19	Iran	Y	N	Drug Repurposing	Sitagliptin	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47387">IRCT20200421047155N1</a>	Therapeutic Effect of Tenofovir and hydroxychloroquine combination therapy compared to chloroquine alone in patients with COVID-19	Iran	Y	N	Drug Repurposing	Tenofovir	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47437">IRCT20200422047168N1</a>	Comparison of the Effectiveness of  Tenofovir antiviral drug beside (Kaletra and Chloroquine) with  routine drug regime (Kaletra and Chloroquine) in  COVID-19 patients	Iran	Y	N	Drug Repurposing	Tenofovir	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47468">IRCT20200408046990N2</a>	Evaluation of colchicine tablet efficacy as an adjuvant treatment for patients with mild to moderate COVID-19 in Qaem Hospital, Mashhad: A triple-blind randomized placebo controlled clinical trial	Iran	Y	N	Drug Repurposing	Colchicine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="http://en.irct.ir/trial/47475">IRCT20180114038350N3</a>	Investigating the effect of Deferiprone on the improvement of symptoms of Coronavirus 2019 (COVID 19)	Iran	Y	N	Drug Repurposing	Deferiprone	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47501">IRCT20120215009014N353</a>	Effect of plasma of patients recovered from covid-19 versus control group on treatment of covid-19: a randomized clinical trial	Iran	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47508">IRCT20140305016852N4</a>	Comparison of three methods of treatment in patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with and without coronavirus positive test (Kovid-19)	Iran	Y	N	Drug Repurposing	Ascorbic acid, Vitamin D3	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47516">IRCT20180425039414N2</a>	The effect of zinc on the treatment and clinical course of patients with SARS-cov2 (COVID-19)	Iran	Y	N	Drug Repurposing	Zinc	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47520">IRCT20200427047215N1</a>	Efficacy and safety  of  oral indomethacin for treatment of covid 19 induced pneumonia	Iran	Y	N	Drug Repurposing	Indomethacin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47576">IRCT20080901001165N50</a>	Investigating the efficacy and safety of Azithromycin inhaled spray in controlling the symptoms of patients with COVID-19	Iran	Y	N	Drug Repurposing	Azithromycin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="http://en.irct.ir/trial/47577">IRCT20080901001165N51</a>	Investigating the efficacy and safety of Hydroxychloroquine nasal spray in controlling the symptoms of patients with COVID-19	Iran	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="http://en.irct.ir/trial/47578">IRCT20200418047121N1</a>	Study of the effectiveness of concomitant use of vitamin C, metformin, azithromycin and doxycycline on improving patients with COVID-19	Iran	Y	N	Drug Repurposing	Azithromycin, Doxycycline, Ascorbic acid, Metformin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47594">IRCT20150808023559N21</a>	The Effect of Convalescent Plasma Therapy on the Outcomes of Patients with 19-COVID	Iran	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47629">IRCT20200501047258N1</a>	Investigation of the effects of COVID-19 convalescent plasma in acute respiratory distress syndrome due to COVID-19	Iran	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Infection rate (prevention)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47641">IRCT20080901001165N52</a>	Investigating the efficacy of high dose of glucocorticoid in patients with moderate to severe pneumonia related to COVID-19	Iran	Y	N	Drug Repurposing	Methylprednisolone, Prednisolone	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47953">IRCT20200508047346N1</a>	Evaluation of the efficacy and safety of Rabbit polyclonal antibody (CoviGlobulin) in patients with coronavirus COVID-19 virus moderate to severe	Iran	Y	N	Cell/Blood based	ND:CoviGlobulin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/48043">IRCT20120215009014N354</a>	Evaluating the effect of intravenous hydrocortisone, methylprednisolone, and dexamethasone in treatment of patients with moderate to severe acute respiratory distress syndrome caused by COVID-19: A double blind randomized clinical trial	Iran	Y	Y	Drug Repurposing	Hydrocortisone, Methylprednisolone, Dexamethasone	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="http://cris.nih.go.kr/cris/en/search/search_result_st01.jsp?seq=16635">KCT0005003</a>	Treatment effect of Nafamostat mesilate in patients with COVID-19 pneumonia: open labelled randomized controlled clinical trial	Korea, Republic of	Y	N	Drug Repurposing	Nafamostat	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://anzctr.org.au/ACTRN12620000445976.aspx">ACTRN12620000445976</a>	Australasian COVID-19 Trial (ASCOT). A multi-centre randomised clinical trial to assess clinical, virological and immunological outcomes in patients with SARS-CoV-2 infection (COVID-19) treated with lopinavir/ritonavir and/or hydroxychloroquine compared to standard of care	Australia	Y	N	Drug Repurposing	Hydroxychloroquine, Lopinavir/ritonavir	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://anzctr.org.au/ACTRN12620000580976.aspx">ACTRN12620000580976</a>	Tocilizumab for the treatment of COVID-19 in intensive care patients: effect on days free of ventilatory support.	Australia	N	N	Drug Repurposing	Tocilizumab	Efficacy - Mortality	Severe Cases	
<a href="http://isrctn.com/ISRCTN85216856">ISRCTN85216856</a>	Investigating the use of convalescent plasma from patients who have recovered from COVID-19 in the management of Ecuadorian patients infected with SARS-CoV-2 with clinical deterioration: IMPACT	Ecuador	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=53859">ChiCTR2000033056</a>	Convalescent Plasma in the treatment of 6 COVID-19 Patients	China	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=53840">ChiCTR2000033049</a>	A clinical study for the efficacy and safety of artemisinin-pipequine tablets in the treatment of the untreated mild or common type novel coronavirus pneumonia (COVID-19) patients	China	N	N	Drug Repurposing	Artemisinin-piperaquine	Efficacy - Viral load	Mild/Moderate Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=54408">ChiCTR2000033372</a>	Efficacy and safety of leflunomide for Refractory novel coronavirus pneumonia (COVID-19): A non-Randomized Controlled Study	China	N	N	Drug Repurposing	Leflunomide	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=54346">ChiCTR2000033323</a>	Severe Reluctant COVID-19 Patients Responding to Convalescent  Plasma; A case series	Iraq	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=54707">ChiCTR2000033627</a>	In vivo use of ivermectin (IVR) for treatment for corona virus infected patients: a randomized controlled trial	Iraq	Y	N	Drug Repurposing	Ivermectin	Efficacy - Viral load	Mild/Moderate Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=54278">ChiCTR2000033491</a>	The Single Oral Favipiravir for Patients with Delayed SARS-Cov-2 viral RNA Clearance	China	N	N	Drug Repurposing	Favipiravir	Efficacy - Viral load	Mild/Moderate Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=55097">ChiCTR2000033774</a>	Evaluating the Efficacy and Safety of Bromhexine Hydrochloride Tablets in Treating Pediatric novel coronavirus pneumonia (COVID-19)	China	Y	N	Drug Repurposing	Bromhexine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Other	
<a href="http://en.irct.ir/trial/46463">IRCT20200128046294N2</a>	A prospective randomized controlled trial comparing Sovodak (Sofosbuvir plus Daclatasvir) in participants with moderate to severe Coronavirus disease (COVID-19) compared to standard of care treatment	Iran	Y	N	Drug Repurposing	Daclatasvir/sofosbuvir	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/46519">IRCT20200314046774N1</a>	Assessment of vitamin A effectiveness on COVID-19 patients and treatment outcomes referred to health centers of Qom province	Iran	Y	N	Drug Repurposing	Vitamin A	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/46718">IRCT20200324046850N3</a>	The effect of naproxen on the healing process of patients with COVID-19	Iran	Y	N	Drug Repurposing	Naproxen	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/46732">IRCT20200324046850N1</a>	Comparison of vitamin D3 and N-acetylcysteine prescription in COVID19 patients   and their effect on recovery process	Iran	Y	Y	Drug Repurposing	Vitamin D3, N-acetylcysteine	Efficacy - Other efficacy	Severe Cases	
<a href="http://en.irct.ir/trial/46783">IRCT20200318046812N1</a>	Evaluation of safety and efficacy of hydroxychloroquine plus favipiravir drug regimen in comparison with hydroxychloroquine plus kaletra on the need for intensive care unit treatment in patients with COVID-19; a randomized, multicenter, parallel groups, open label study	Iran	Y	N	Drug Repurposing	Favipiravir, Lopinavir/Ritonavir	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/46867">IRCT20190810044500N5</a>	Investigation of the efficacy and safety of colchicine In combination with standard treatment on covid-19 patients: A clinical trial	Iran	Y	N	Drug Repurposing	Colchicine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/46875">IRCT20200401046909N1</a>	The efficacy of oral 25-hydroxyvitamin D3 on  COVID-19 treatment in adults: A Randomized, Controlled Double-Blind Clinical Trial.	Iran	Y	N	Drug Repurposing	Vitamin D3	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/46897">IRCT20180725040596N2</a>	Evaluation of the effect of Arbidol drug in the treatment of hospitalized patients with COVID-19	Iran	Y	N	Drug Repurposing	Umifenovir, Lopinavir/ritonavir	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="http://en.irct.ir/trial/46904">IRCT20200404046947N1</a>	Study of Methylprednisolone effects on treatment and clinical symptoms and laboratory signs of Iranian ?COVID-19 patients: a clinical trial study	Iran	Y	N	Drug Repurposing	Methylprednisolone	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="http://en.irct.ir/trial/46963">IRCT20151228025732N52</a>	A study on melatonin and Vitamin C and zinc efficacy in patients with COVID19 hospitalized in intensive care unit of Semnan Kowsar Hopsital	Iran	Y	N	Drug Repurposing, Other	ND:Zinc, Ascorbic acid	Efficacy - Oxygen parameters	Severe Cases	
<a href="http://en.irct.ir/trial/46975">IRCT20081027001411N3</a>	Study of Prednisolone effects on treatment and clinical symptoms and laboratory signs of Iranian COVID-19 patients: a clinical trial study	Iran	Y	N	Drug Repurposing	Methylprednisolone	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/46983">IRCT20091201002804N12</a>	The effect of surfactant on clinical outcome of patients with COVID-19 under mechanical ventilation	Iran	Y	N	Drug Repurposing	Beractant	Efficacy - Oxygen parameters	Severe Cases	
<a href="http://en.irct.ir/trial/47010">IRCT20200401046909N2</a>	Investigating preventive effects of oral 25-hydroxyvitamin D3 on COVID-19 in adults: A  Randomized, Controlled Double-Blind Clinical Trial.	Iran	Y	N	Drug Repurposing	Vitamin D3	Efficacy - Infection rate (prevention)	General population	
<a href="http://en.irct.ir/trial/47030">IRCT20200217046526N1</a>	Mesenchymal Stem Cell Therapy for Acute Respiratory Distress Syndrome in Coronavirus Infection : A Phase 1 and 2 clinical trial	Iran	N	N	Cell/Blood based	ND:Stem cells	Safety	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47062">IRCT20190727044343N3</a>	Evaluation of ANIF1 antiviral drug in COVID-19 patients: A Randomized Clinical Trial	Iran	Y	N	Shelved drug or NME	ANIF1	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47188">IRCT20081019001369N6</a>	Evaluation of the effect of trans sodium crocetinate in respiratory distress caused by COVID-19	Iran	Y	N	Shelved drug or NME	Trans sodium crocetinate	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47197">IRCT20091012002582N21</a>	Effect of intratracheal Injection of Processed Autologous Serum Derived from Patients with covid-19 in oxygenation parameters and pulmonary Complications	Iran	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Oxygen parameters	Severe Cases	
<a href="http://en.irct.ir/trial/47200">IRCT20200325046859N2</a>	evaluation of the effects of the 2-drug diet (hydroxychloroquine + umifenovir(Arbidol)) compared with Hydroxy chlorquine on the of mortality rate in patients with moderate symptoms of COVID-19 infections: A  randomized interventional study in Imam Reza Hospital, Mashhad.	Iran	N	N	Drug Repurposing	Umifenovir	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="http://en.irct.ir/trial/47279">IRCT20200411047019N1</a>	Investigating the Effect of BCG Vaccine on Preventing COVID-19 Infection in Healthcare Staff Exposed to SARS-CoV-2	Iran	Y	N	Vaccine	BCG Vaccine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="http://en.irct.ir/trial/47335">IRCT20150303021315N19</a>	The evaluation of safety and efficacy of Pembrolizumab (CinnaGen Co, Iran) in patients with COVID-19	Iran	N	N	Drug Repurposing	Pembrolizumab	Efficacy - Mortality	Mild/Moderate Cases	
<a href="http://en.irct.ir/trial/47609">IRCT20200501047259N1</a>	Intravenous immunoglubolin (IVIG) effect on improvement of severe pulmonary damage in COVID 19 disease	Iran	Y	N	Cell/Blood based	ND:Immunoglobulin	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47692">IRCT20200502047268N1</a>	Evaluation of the effect of GCSF injection in treatment of COVID-19 patients with lymphopenia (less than 1000)	Iran	Y	N	Drug Repurposing	Granulocyte colony-stimulating factor	Efficacy - Other efficacy	Other	
<a href="http://en.irct.ir/trial/47707">IRCT20200418047126N1</a>	Evaluation of the therapeutic effect of colchicine plus chloroquine in comparison with chloroquine in patients with COVID-19	Iran	Y	N	Drug Repurposing	Colchicine	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47722">IRCT20200405046951N1</a>	The effect of supplementation with vitamin A on improvement of symptoms of acute respiratory syndrome in patients with COVID-19: A randomized clinical trial	Iran	Y	N	Drug Repurposing	Vitamin A	Efficacy - Oxygen parameters	Severe Cases	
<a href="http://en.irct.ir/trial/47964">IRCT20200421047150N1</a>	Assessment of safety, efficacy and effective dose determination of human umbilical cord Wharton   s jelly mesenchymal stem cell transplantation on treatment of COVID-19 (coronavirus)  pneumonia and complications in humans	Iran	Y	N	Cell/Blood based	ND:Stem cells	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47989">IRCT20140428017469N1</a>	Short-term Protection for COVID-19 by Oral Polio Vaccine	Iran	N	N	Vaccine	ND:Polio vaccine	Efficacy - Infection rate (prevention)	General population, Other	
<a href="http://en.irct.ir/trial/48018">IRCT20151227025726N15</a>	Evaluation the efficacy and safety of Umifenovir (Arbidol) Administration in comparison with Lopinavir-ritonavir (Kaletra) in COVID-19 patients	Iran	Y	N	Drug Repurposing	Umifenovir	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="http://en.irct.ir/trial/48019">IRCT20150716023235N15</a>	The use of sex hormones in the control of coronavirus inflammation	Iran	Y	N	Drug Repurposing	Testosterone, Progesterone	Efficacy - Clinical improvement (except WHO scale)	Other	
<a href="http://en.irct.ir/trial/48024">IRCT20200510047383N1</a>	Evaluation of the effect of Tocilizumab on outcomes of the severe COVID-19, determining indications within the paradigm of host-directed therapy	Iran	Y	N	Drug Repurposing	Tocilizumab	Efficacy - Mortality	Severe Cases	
<a href="http://en.irct.ir/trial/48039">IRCT20120215009014N355</a>	Evaluating the effect of intravenous N-acetyl cysteine versus placebo in the treatment of patients with mild and moderate acute respiratory distress syndrome caused by COVID-19: A double-blind randomized clinical trial	Iran	Y	N	Drug Repurposing	N-acetylcysteine	Efficacy - Mortality	Mild/Moderate Cases	
<a href="http://en.irct.ir/trial/48049">IRCT20170731035423N2</a>	Effect of the combination of BCc1 & Hep-S on the improvement of clinical & laboratory symptoms of hospitalized COVID-19 patients in a randomized, double-blind, clinical trial	Iran	Y	N	Shelved drug or NME	BCc1 nanomedicine, Hep-s	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/48061">IRCT20080901001165N55</a>	Investigating the efficacy and safety of N-Acetyl Cysteine (NAC) inhalation spray in controlling the symptoms of patients with COVID-19	Iran	Y	N	Drug Repurposing	N-acetylcysteine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/48066">IRCT20080901001165N53</a>	Investigating the efficacy and safety of Interferon Beta1a nasal spray in controlling the symptoms of patients with COVID-19	Iran	Y	N	Drug Repurposing	Interferon Beta-1A	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/48153">IRCT20151227025726N17</a>	Evolution of the efficacy and safety of Dexamethasone administration in patients with mild to moderate COVID-19 acute respiratory disease syndrome	Iran	Y	N	Drug Repurposing	Dexamethasone	Efficacy - Oxygen parameters	Mild/Moderate Cases	
<a href="http://en.irct.ir/trial/48176">IRCT20200516047468N1</a>	Interventional study of intravenous vitamin C in definitive patients with covid 19 and its effect on changes in lung CT scan and clinical and laboratory symptoms of patients	Iran	Y	N	Drug Repurposing	Ascorbic acid	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/48185">IRCT20150107020592N23</a>	Plasmapheresis and plasma exchanges;usefulness in covid-19 critically ill patients	Iran	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Oxygen parameters	Severe Cases	
<a href="http://en.irct.ir/trial/48187">IRCT20160809029275N1</a>	Evolution of Allogenic Mesenchymal stem cell- derived Umbilical cord  transplantation for ARDS patients infected with COVID19.	Iran	Y	N	Cell/Blood based	ND:Stem cells	Efficacy - Oxygen parameters	Severe Cases	
<a href="http://en.irct.ir/trial/48226">IRCT20200517047485N1</a>	Evaluation of the efficacy and side effects of combination therapy of Kaletra and Hydroxychloroquine in comparison with Atazanavir / Ritonavir and Hydroxychloroquine in the treatment of patients with COVID-19	Iran	Y	N	Drug Repurposing	Atazanavir/ritonavir, Lopinavir/ritonavir	Efficacy - Oxygen parameters	Mild/Moderate Cases	
<a href="http://en.irct.ir/trial/48262">IRCT20150107020592N22</a>	Cyclosporin for the Prevention and Treatment of COVID-19 Disease	Iran	N	N	Drug Repurposing	Cyclosporine	Efficacy - Other efficacy	Severe Cases	
<a href="http://en.irct.ir/trial/48312">IRCT20151227025726N18</a>	The effect of pentaglobin in the treatment of critically ill patients with COVID-19	Iran	Y	N	Cell/Blood based	ND:Immunoglobulin	Efficacy - Oxygen parameters	Severe Cases	
<a href="http://en.irct.ir/trial/48329">IRCT20161206031256N3</a>	Evaluation and comparison of the effect of two interferon alpha and beta antiviral drugs on the prognosis of patients with COVID 19	Iran	Y	Y	Drug Repurposing	Interferon alpha, Interferon beta	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/48444">IRCT20200422047168N2</a>	A randomized clinical trial study, comparison of the therapeutic effects of Ivermectin, Kaletra and Chloroquine with Kaletra and Chloroquine in the treatment of patients with coronavirus 2019 (COVID-19)	Iran	Y	N	Drug Repurposing	Ivermectin	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/48495">IRCT20200523047550N1</a>	Evaluating effectiveness and safety of Umifenovir in the treatment (COVID-19)infection In patients referred to Tehran Imam Khomeini Hospital Complex	Iran	N	N	Drug Repurposing	Umifenovir	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/48517">IRCT20160118026097N3</a>	Evaluation of   interferon treatment in  high-risk covid19 patients in Qom	Iran	Y	N	Drug Repurposing	Interferon beta-1b	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/48702">IRCT20120703010178N20</a>	?Evaluation of Safety and efficacy of anakinra utilization in COVID-19, a randomized controlled clinical trial	Iran	Y	N	Drug Repurposing	Anakinra	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/48749">IRCT20200412047042N1</a>	Evaluation the effect of raltegravir, and raltegravir/interferon beta combination on covid 19 patients admitted in Peymanieh hospital of Jahrom in 2020	Iran	Y	Y	Drug Repurposing	Raltagravir, Interferon beta	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrials.jp/user/showCteDetailE.jsp?japicId=JapicCTI-205270">JPRN-JapicCTI-205270</a>	A Study to Evaluate the Safety and Efficacy of Tocilizumab in Patients With Severe COVID-19 Pneumonia in Japan	Japan	N	N	Drug Repurposing	Tocilizumab	Safety	Severe Cases	
<a href="https://jrct.niph.go.jp/latest-detail/jRCTs031190227">JPRN-jRCTs031190227</a>	A prospective multi-center open trial to evaluate the safety and efficacy of triple combination therapy of  lopinavir , ritonavir and hydroxychloroquine sulfate in patients infected with COVID-19.	Japan	N	N	Drug Repurposing	Hydroxychloroquine, Lopinavir/ritonavir	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://jrct.niph.go.jp/latest-detail/jRCTs041190120">JPRN-jRCTs041190120</a>	Multicenter, open-label, randomized trial of favipiravir in asymptomatic and minimally symptomatic patients infected with SARS-CoV2 to evaluate viral load reduction	Japan	Y	N	Drug Repurposing	Favipiravir	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://jrct.niph.go.jp/latest-detail/jRCTs061200002">JPRN-jRCTs061200002</a>	Randomized controlled trial of teprenone for preventing aggravation of COVID-19	Japan	Y	N	Drug Repurposing	Teprenone	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://anzctr.org.au/ACTRN12620000501943.aspx">ACTRN12620000501943</a>	Effectiveness of Prophylactic Hydroxychloroquine on incidence of COVID-19 infection in Front-line Health and Allied Health Care Workers: The COVID-SHIELD Trial	Australia	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://anzctr.org.au/ACTRN12620000676910.aspx">ACTRN12620000676910</a>	Allogeneic Amniotic Epithelial Cells for the Treatment of COVID-19 related respiratory failure, a pilot feasibility randomised controlled trial	Australia	Y	N	Cell/Blood based	ND:Amniotic epithelial cells	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="http://isrctn.com/ISRCTN33578935">ISRCTN33578935</a>	Rationale and investigational study for the treatment of COVID-19 with severe viral pneumonia with isolated, placental, mesenchymal stem cell exosomes	Germany	Y	N	Cell/Blood based	ND:Stem cell exosomes	Safety	Severe Cases	
<a href="http://isrctn.com/ISRCTN40302986">ISRCTN40302986</a>	A double-blind clinical trial to repurpose and assess the efficacy and safety of ivermectin in COVID-19	Nigeria	Y	N	Drug Repurposing	Ivermectin	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=55524">ChiCTR2000034112</a>	A Phase I clinical trial to evaluate the safety, tolerance and preliminary immunogenicity of different doses of a SARS-CoV-2 mRNA vaccine in population aged 18-59 years and 60 years and above	China	Y	Y	Vaccine	ND:Vaccine	Safety	Other	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=55582">ChiCTR2000034076</a>	A safety and immune response trial of novel coronavirus pneumonia (COVID-19) S-Vax loaded autologous dendritic cells	China	N	N	Vaccine	ND:Vaccine	Safety	Other	
<a href="https://anzctr.org.au/ACTRN12620000707965.aspx">ACTRN12620000707965</a>	A Multicenter, Phase III, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy of the recombinant BCG VPM1002 on the Incidence or Disease Severity of SARS-COV-2/COVID-19 Among High-Risk Participants in Australia 	Australia	Y	N	Vaccine	ND: VPM1002 vaccine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://anzctr.org.au/ACTRN12620000612910.aspx">ACTRN12620000612910</a>	A pilot, open-label, randomised controlled clinical trial to investigate early efficacy of CYP-001 in adults admitted to intensive care with COVID-19	Australia	Y	N	Cell/Blood based	ND:Stem cells	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://slctr.lk/trials/slctr-2020-011">SLCTR/2020/011</a>	Hydroxychloroquine for Post-Exposure Prophylaxis of COVID-19 among naval personnel: a placebo-controlled, randomized, clinical trial	Sri Lanka	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="http://en.irct.ir/trial/46531">IRCT20151113025025N3</a>	Clinical Trial of renin-angiotensin-aldosterone system inhibitors with halting their administration and the effect on clinical outcomes of patients with coronavirus disease-2019 (COVID-19) referring to Sina and Imam-Khomeini Hospitals in 2020	Iran	N	N	Drug Repurposing, Other		Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47357">IRCT20200416047099N2</a>	Plasma exchange in patients with COVID-19 to reduce viral load and inflammatory molecules	Iran	N	N	Cell/Blood based	ND:Plasma exchange	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/47637">IRCT20200428047232N1</a>	Effectiveness and safety of thalidomide in moderate COVID-19 pneumonia: A randomized clinical trial	Iran	Y	N	Drug Repurposing	Thalidomide	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="http://en.irct.ir/trial/47696">IRCT20171105037262N4</a>	Evaluation of adalimumab effect on clinical symptoms including respiratory distress, oxygen saturation and lung involvement of patients with COVID-19	Iran	Y	N	Drug Repurposing	Adalimumab	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/48048">IRCT20200511047396N1</a>	Efficacy evaluation of inhalation therapy (nasal spray) of Interferon Beta-1a in hospitalized Covid-19 patients	Iran	Y	N	Drug Repurposing	Interferon Beta-1a	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="http://en.irct.ir/trial/48083">IRCT20180425039414N3</a>	The effect of vitamin C and E in the treatment and clinical course of patients with SARS-cov2 (COVID-19)	Iran	Y	N	Drug Repurposing	Ascorbic acid, Vitamin E	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/48099">IRCT20200510047385N1</a>	Effect of stromal vascular fraction (SVF), blood and condition medium derived exosomes on treatment of covid-19 patients with Acute Respiratory Distress Syndrome(ARDS)/ clinical Trial	Iran	Y	Y	Cell/Blood based	ND:Convalescent plasma	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/48236">IRCT20200513047426N1</a>	The prophylactic effect of oral hydroxy-chloroquine in close contacts of COVID-19 patients	Iran	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="http://en.irct.ir/trial/48287">IRCT20110726007117N11</a>	Effect of  vitamin D supplementation in diagnosed cases of  2019 Novel Coronavirus; a randomized clinical trial	Iran	Y	N	Drug Repurposing	Vitamin D3	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/48330">IRCT20200112046089N1</a>	Evaluation of the effect of Resveratrol on the effectiveness of antiviral drug regimen in patients with COVID-19	Iran	Y	N	Shelved drug or NME	Resveratrol	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/48396">IRCT20081027001411N4</a>	Study of Tocilizumab effect on treatment and clinical symptoms and laboratory signs of Iranian COVID-19 patients: a ?crinical trial study	Iran	Y	N	Drug Repurposing	Tocilizumab	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/48493">IRCT20200525047562N1</a>	Immediate uses of convalescent covid-19 plasma in the treatment of new infected patients at the first day of hospitalization in a clinical trail	Iran	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/48500">IRCT20200317046797N6</a>	Effect of edaravone on clinical improvement and outcome of patients with respiratory distress syndrome caused by COVID-19	Iran	Y	N	Drug Repurposing	Edaravone	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/48640">IRCT20200504047298N1</a>	Evaluation of Atazanavir/Ritonavir effect on COViD-19 patients treatment in comparison with Lopinavir / Ritonavir	Iran	Y	N	Drug Repurposing	Atazanavir, Ritonavir	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/48717">IRCT20200608047686N1</a>	Evaluation of therapeutic effects of Metronidazole In Inpatients with Pneuomonia Due to COVID-19	Iran	Y	N	Drug Repurposing	Metronidazole	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/48746">IRCT20150107020592N26</a>	Favipiravir effectiveness in patients undergoing COVID19 Acute respiratory distress syndrome (ARDS)	Iran	N	N	Drug Repurposing	Favipiravir	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/48764">IRCT20200609047707N1</a>	Effective of Elman tablet on illness severity and length of hospital stay in the patients with COVID-19 infection	Iran	Y	N	Shelved drug or NME	Elman	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/48907">IRCT20150107020592N27</a>	The effect of pentaglobin in the treatment of critically ill patients with COVID-19	Iran	N	N	Shelved drug or NME	Pentaglobin	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/48929">IRCT20200515047456N1</a>	Evaluation of  Tissue Plasminogen Activator (tPA) in comparition of anticoagulation for treatment of critical COVID 19 patient	Iran	Y	N	Drug Repurposing	Alteplase	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/48992">IRCT20150107020592N30</a>	Favipiravir prophylactic to reduce the involvement of health care workers in the COVID-19 epidemic	Iran	N	N	Drug Repurposing	Favipiravir	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="http://en.irct.ir/trial/49112">IRCT20150725023332N3</a>	The effect of Bromelain and Montelukast on Clinical and non-Clinical parameters in Covid-19 patients	Iran	Y	Y	Drug Repurposing, Other	Montelukast, ND:Bromelain	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/49132">IRCT20190121042444N3</a>	Considering the administration of Desferral supplementary and Vitamin C on the ferritin levels of Quid 19 patients	Iran	Y	N	Drug Repurposing	Deferoxamine, Ascorbic acid	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="http://en.irct.ir/trial/49174">IRCT20111224008507N3</a>	Effectiveness of Ivermectin in the Treatment of Coronavirus Infection in Patients admitted to Educational Hospitals of Mazandaran in 2020	Iran	Y	N	Drug Repurposing	Ivermectin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/49198">IRCT20200624047908N1</a>	Evaluation of the effect of sofosbuvir/daclatasvir  in COVID-19 patients: A randomized double-blind clinical trial	Iran	Y	N	Drug Repurposing	Sofosbuvir/Daclatasvir	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://en.irct.ir/trial/49385">IRCT20200426047206N2</a>	Clinical trial of efficacy and safety of mesenchymal stem cell transplantation in patients with COVID-19 pneumonia	Iran	Y	N	Drug Repurposing	ND:Stem cells	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://jrct.niph.go.jp/latest-detail/jRCT2031200035">JPRN-jRCT2031200035</a>	A Multicenter, Adaptive, Randomized Blinded Controlled Trial of the Safety and Efficacy of Investigational Therapeutics for the Treatment of COVID-19 in Hospitalized Adults - Adaptive COVID-19 Treatment Trial (ACTT-2)	Japan	Y	N	Drug Repurposing, Shelved drug or NME	Baricitinib, Remdesivir	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://jrct.niph.go.jp/latest-detail/jRCTs031190226">JPRN-jRCTs031190226</a>	A prospective multi-center open trial to evaluate the safety and efficacy of favipiravir in patients infected with COVID-19.	Japan	N	N	Drug Repurposing	Favipiravir	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://jrct.niph.go.jp/latest-detail/jRCTs031200026">JPRN-jRCTs031200026</a>	Multicenter, Single blinded Randomized Controlled, Comparative Study to Evaluate the Efficacy and Safety of Favipiravir and Nafamostat Mesilate in Patients with COVID-19 Pneumonia	Japan	Y	N	Drug Repurposing	Favipiravir, Nafamostat	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://jrct.niph.go.jp/latest-detail/jRCTs041200025">JPRN-jRCTs041200025</a>	Japanese, multicenter, phase II trial of combination therapy with favipiravir and corticosteroids for coronavirus disease 2019 (COVID-19) patients with mild respiratory failure - J-CRITICAL trial	Japan	N	N	Drug Repurposing	Favipiravir, Methylprednisolone	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=10928">PACTR202004801273802</a>	A Multi-Center, Randomized, Double-Blind, Placebo-Controlled Clinical Trial of the Efficacy and Safety of Chloroquine Phosphate, Hydroxychloroquine sulphate and Lopinavir/Ritonavir for the Treatment of COVID-19 in Lagos State.     	Nigeria	Y	Y	Drug Repurposing	Chloroquine, Hydroxychloroquine, Lopinavir/Ritonavir	Efficacy - WHO scale	Severe Cases	
<a href="https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=10971">PACTR202005599385499</a>	The host Epigenetic methylation repair in COVID-19 using Folic acid: A new suggested prevention and treatment.	Egypt	N	N	Drug Repurposing	Folic acid	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=10981">PACTR202004893013257</a>	PROTECT-Surg	Ghana	Y	Y	Drug Repurposing	Hydroxychloroquine, Lopinavir/Ritonavir	Efficacy - Other efficacy	Other	
<a href="https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=10988">PACTR202005681895696</a>	A phase Ib/II single-blinded, randomised, controlled study to determine safety, immunogenicity and efficacy of the candidate Coronavirus Disease (COVID-19) vaccine ChAdOx1 nCoV-19 in adults in Kenya	Kenya	Y	N	Vaccine	ND: Vaccine ChAdOx1	Safety	General population	
<a href="https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=11053">PACTR202005622389003</a>	Efficacy and safety of Hydroxychloroquine, Azythromycine and Zinc for the treatment of patients with SARS-Cov2 infection in Senegal: a dose ranging randomised trial. COVID-19	Senegal	Y	N	Drug Repurposing	Hydrochloroquine, Azythromycine, Zinc	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=11103">PACTR202006899597082</a>	Randomized clinical trial, phase 2, to evaluate the efficacy of Artesunate IV alone or combined with vitamin C IV for the treatment of COVID-19	Madagascar	Y	Y	Drug Repurposing	Artesunate, Ascorbic acid	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=12150">PACTR202006537901307</a>	An open-label, multicentre, randomised, adaptive platform trial of the safety and efficacy of several therapies, including antiviral therapies, versus control in mild/moderate cases of COVID-19	Switzerland	Y	N	Drug Repurposing	Lopinavir/Ritonavir, Hydroxychloroquine	Efficacy - Oxygen parameters	Mild/Moderate Cases	
<a href="https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=12158">PACTR202007606032743</a>	Nebulized heparin in patients with mainly moderate coronavirus disease 2019: Randomized controlled trial. COVID-19	Egypt	Y	N	Drug Repurposing	Heparin	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=12166">PACTR202006922165132</a>	COVID-19: An Adaptive Phase I/II Randomized Placebo-controlled Trial to Determine Safety, Immunogenicity and Efficacy of Non-replicating ChAdOx1 SARSCoV-2 Vaccine in South African Adults Living Without HIV; and Safety and Immunogenicity in Adults Living With HIV.	South Africa	Y	Y	Vaccine	ND:ChAdOx1 vaccine	Safety	General population, Other	
<a href="https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=12168">PACTR202006760881890</a>	A Multi-Center, Randomized, Double-Blind, Placebo- Controlled Clinical Trial of the Safety and Efficacy of Convalescent Plasma for the Treatment of COVID-19 in Hospitalized Patients in Lagos State 	Nigeria	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Viral load	Severe Cases, Other	
<a href="https://pactr.samrc.ac.za/TrialDisplay.aspx?TrialID=12175">PACTR202006883882711</a>	Effectiveness of Measles, Mumps and Rubella Vaccine in Health Care Professionals for COVID-19	Egypt	Y	N	Drug Repurposing, Vaccine	ND: MMR vaccine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="http://www.ensaiosclinicos.gov.br/rg/RBR-8969zg/">RBR-8969zg</a>	Clinical Trial using N-acetylcysteine for treatment of 2019-nCoV Pneumonia	Brazil	Y	N	Drug Repurposing	N-acetylcysteine	Efficacy - Mortality	Severe Cases	
<a href="http://www.ensaiosclinicos.gov.br/rg/RBR-3k4wxb/">RBR-3k4wxb</a>	Evaluation of the use of Hydroxychlorochine in patients with discrete form of Covid-19: randomized clinical trial	Brazil	Y	Y	Drug Repurposing	Hydroxychloroquine, Azithromycin	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://www.ensaiosclinicos.gov.br/rg/RBR-4vm3yy/">RBR-4vm3yy</a>	Use of convalescent plasma submitted to pathogen inactivation for the treatment of patients with severe COVID-19	Brazil	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="http://www.ensaiosclinicos.gov.br/rg/RBR-949z6v/">RBR-949z6v</a>	Full versus prophylactic heparinization for the treatment of severe forms of SARS-Covid-19: clinical, randomized, open and controlled study - HeSAcovid trial	Brazil	Y	N	Drug Repurposing	Enoxaparin	Efficacy - Oxygen parameters	Severe Cases	
<a href="http://www.ensaiosclinicos.gov.br/rg/RBR-876qb5/">RBR-876qb5</a>	Eculizumab for the treatment of Covid-19 severe cases - : Eculizumabe for COVID	Brazil	N	N	Drug Repurposing	Eculizumab	Efficacy - Mortality	Severe Cases	
<a href="http://www.ensaiosclinicos.gov.br/rg/RBR-3zdynp/">RBR-3zdynp</a>	Clinical Characterisation Protocol for Severe Emerging Infections ISARIC/WHO: COVID-19	Brazil	Y	N	Drug Repurposing	Tocilizumab	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="http://www.ensaiosclinicos.gov.br/rg/RBR-7jqpnw/">RBR-7jqpnw</a>	Therapeutic effectiveness of COVID-19 convalescent plasma produced by HEMOPE: a multicenter, randomized and controlled clinical trial - PLAVID-TRIAL: Covid convalescent plasma - Clinical Trial	Brazil	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="http://www.ensaiosclinicos.gov.br/rg/RBR-5vpyh4/">RBR-5vpyh4</a>	Use of Anti-IL-17 in patients with the severe acute respiratory syndrome (SARS) associated with Covid-19	Brazil	Y	N	Drug Repurposing	Secuquinumab	Efficacy - Other efficacy	Severe Cases	
<a href="http://www.ensaiosclinicos.gov.br/rg/RBR-3rywwg/">RBR-3rywwg</a>	A phase IIb, double-blind, randomized controlled trial to evaluate the efficacy and safety of Naproxen compared to placebo in combination with Azithromycin or Levofloxacin in patients with Severe Acute Respiratory Syndrome during the Covid-19 pandemic	Brazil	Y	N	Drug Repurposing	Naproxen	Efficacy - Mortality	Severe Cases	
<a href="http://www.clinicaltrials.in.th/index.php?tp=regtrials&menu=trialsearch&smenu=fulltext&task=search&task2=view1&id=6236">TCTR20200514001</a>	An Investigation of the Efficacy and Safety of Favipiravir in COVID-19 Patients without Pneumonia   ?? An open-label randomized controlled study   ??	Thailand	Y	N	Drug Repurposing	Favipiravir	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="http://www.clinicaltrials.in.th/index.php?tp=regtrials&menu=trialsearch&smenu=fulltext&task=search&task2=view1&id=5995">TCTR20200404004</a>	Comparative effectiveness of chloroquine and vitamin C prophylaxis in household contacts of confirmed COVID-19 patients	Thailand	Y	N	Drug Repurposing	Chloroquine, Ascorbic acid	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://www.ins.gob.pe/ensayosclinicos/rpec/recuperarECPBNuevoEN.asp?numec=013-20">PER-013-20</a>	CONVALESCENT PLASMA USE AS TREATMENT FOR HOSPITALIZED PATIENTS WITH COVID-19 IN ESSALUD	Peru	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://www.ins.gob.pe/ensayosclinicos/rpec/recuperarECPBNuevoEN.asp?numec=016-20">PER-016-20</a>	PERUCONPLASMA: RANDOMIZED CLINICAL TRIAL TO EVALUATE SAFETY AND EFFICACY OF THE USE OF CONVALESCENT PLASMA IN HOSPITALIZED PATIENTS WITH COVID-19	Peru	Y	N	Cell/Blood based	ND:Convalescent plasma	Safety	Mild/Moderate Cases, Severe Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=42638">CTRI/2020/03/024402</a>	Hydroxy Chloroquine, in open labelled, Randomised intervention for prevention of new infection and adverse outcomes following COVID-19 infection- A Tertiary Hospital based study - CORONA study	India	N	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=42713">CTRI/2020/04/024479</a>	Open labelled Randomised controlled trial to study the effect of Chloroquine in addition to standard therapy in COVID-19 patients	India	Y	N	Drug Repurposing	Chloroquine	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=42933">CTRI/2020/04/024729</a>	Topical Chloroquine Nasal Drops in Early Stage Covid 19- Impact on Viral load and cure rates	India	Y	N	Drug Repurposing	Chloroquine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=43149">CTRI/2020/04/024775</a>	A Phase II, Open Label, Randomized Controlled Trial to Assess the Safety and Efficacy of Convalescent Plasma to Limit COVID-19 Associated Complications in Moderate Disease. - PLACID	India	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=42972">CTRI/2020/04/024749</a>	A Multicenter, Phase III, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Efficacy of Recombinant BCG VPM1002 in Reducing Infection Incidence and Disease Severity of SARS-COV-2/COVID-19 Among High-Risk Subjects	India	Y	N	Drug Repurposing	BCG Vaccine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=42843">CTRI/2020/04/024806</a>	Efficacy of Imatinib in mild SARS CoV2 infection: A randomized study	India	Y	N	Drug Repurposing	Imatinib	Efficacy - Viral load	Mild/Moderate Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=42849">CTRI/2020/04/024804</a>	Open Label, parallel arm, phase I/II clinical trial to evaluate Safety and efficacy of Convalescent Plasma as Therapy for Covid-19 Severe SARS-CoV-2 Disease	India	N	N	Cell/Blood based	ND:Convalescent plasma	Safety	Mild/Moderate Cases, Severe Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=43105">CTRI/2020/04/024833</a>	Effect of BCG-Denmark (Green Signal) on prevention of COVID 19 infection in health care workers   ?? a double blind randomized controlled trial	India	Y	N	Drug Repurposing	BCG Vaccine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=43004">CTRI/2020/04/024846</a>	A clinical trial to evaluate the safety and efficacy of Mycobacterium W in critically ill patients suffering from COVID 19 infection	India	Y	N	Shelved drug or NME	ND:Mycobacterium	Efficacy - Other efficacy	Severe Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=43130">CTRI/2020/04/024904</a>	Randomised Controlled Trial to compare efficacy of  hydroxychloroquine alone and in combination with azithromycin  in treatment of COVID-19  - HAZES	India	Y	Y	Drug Repurposing	Hydroxychloroquine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=43364">CTRI/2020/04/024948</a>	EFFICACY OF HYDROXYCHLOROQUINE, CICLESONIDE AND IVERMECTIN IN TREATMENT OF MODERATE COVID-19 ILLNESS: AN OPEN-LABEL RANDOMISED CONTROLLED STUDY - EHYCIVER-COVID	India	Y	N	Drug Repurposing	Hydroxychloroquine, Ciclesonide, Ivermectin	Efficacy - Viral load	Mild/Moderate Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=43400">CTRI/2020/04/024949</a>	EFFICACY OF ORAL NICLOSAMIDE IN TREATMENT OF MILD AND VERY MILD COVID-19 CASES: AN OPEN-LABEL RANDOMIZED CONTROLLED TRIAL - EONIC-COVID	India	Y	N	Drug Repurposing	Niclosamide	Efficacy - Viral load	Mild/Moderate Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=43338">CTRI/2020/05/024967</a>	A Prospective, Open label observational clinical study to evaluate the efficacy and safety of MyVir tablets to improve immunity in quarantine patients of COVID-19	India	N	N	Shelved drug or NME	MyVir	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=42878">CTRI/2020/05/024959</a>	A Multi-Centre, Open label, Two Arm Randomized, Pivotal Phase 2 Trial to Study the Efficacy and Safety of Itolizumab in COVID-19 Complications	India	Y	N	Drug Repurposing	Itolizumab	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=43237">CTRI/2020/05/024962</a>	Effectiveness of topical povidone iodine (PVP-I) oropharyngeal and intranasal application during the current coronavirus pandemic amongst COVID-19 positive patients in Andhra Pradesh, India	India	Y	N	Shelved drug or NME	Povidone-Iodine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=42858">CTRI/2020/05/025013</a>	Phase 2 Clinical Trial for the Evaluation of BCG as potential therapy for CoVID-I9 - COVID-19 BCG	India	Y	N	Drug Repurposing	BCG Vaccine	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=43183">CTRI/2020/05/025022</a>	An open label randomised  controlled trial to assess the efficacy of Hydroxychloroquine in patients with mild COVID -19  illness with risk factors for severe disease.	India	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=43019">CTRI/2020/05/025067</a>	A randomized controlled trial of hydroxychloroquine prophylaxis for Healthcare Workers exposed to COVID-19	India	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=43449">CTRI/2020/05/025068</a>	A Phase IIB open label randomized controlled trial to evaluate the efficacy and safety of Ivermectin in reducing viral loads in patients with hematological disorders who are admitted with COVID 19 infection - Not applicable	India	Y	N	Drug Repurposing	Ivermectin	Efficacy - Viral load	Other	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=43504">CTRI/2020/05/025114</a>	A Randomized, Open-label, multicenter study to evaluate the efficacy and safety of Favipiravir combined with STANDARD  supportive care in adult Indian patients with mild to moderate COVID-19	India	Y	N	Drug Repurposing	Favipiravir	Efficacy - Viral load	Mild/Moderate Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=43378">CTRI/2020/05/025167</a>	Evaluation of Efficacy and Safety of Thymoquinone compared to Best supportive care in Patients with COVID-19.	India	Y	N	Shelved drug or NME	Thymoquinone	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=43251">CTRI/2020/05/025209</a>	AN OPEN LABEL RANDOMISED  CONTROL TRIAL ON PASSIVE IMMUNIZATION WITH CONVALESCENT PLASMA IN SEVERE COVID-19 DISEASE - PICP19	India	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Mortality	Severe Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=43728">CTRI/2020/05/025224</a>	Interventional study to assess the efficacy of Ivermectin with standard of care treatment versus standard of care in patients of COVID-19 at R D Gardi Medical College, Ujjain, India	India	Y	N	Drug Repurposing	Ivermectin	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=43057">CTRI/2020/05/025242</a>	Population pharmacokinetics of hydroxychloroquine sulphate in healthcare workers given for prophylaxis against Corona Virus Disease 2019 (COVID 19) pandemic in India	India	N	N	Drug Repurposing	Hydroxychloroquine	Other	Exposed individuals (family members, HCP)	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=43206">CTRI/2020/05/025271</a>	A Randomized, Double-blind, Two arm, controlled clinical trial to compare the Efficacy and Safety of Mycobacterium w (Mw) administered along with Standard of care versus Placebo administered along with Standard of care, in adult, COVID 19 positive patients hospitalized but not critically ill.	India	Y	N	Shelved drug or NME	Mycobacterium	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=43176">CTRI/2020/05/025277</a>	A Randomized, Double-blind, Two arm, Placebo Controlled Clinical Trial to Evaluate the Efficacy and Safety of Mycobacterium w in preventing COVID-19 in subjects at risk of getting infected with COVID-19.	India	Y	N	Shelved drug or NME	Mycobacterium	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=43752">CTRI/2020/05/025299</a>	Convalescent Plasma to Limit Coronavirus Associated Complications: An Open label Clinical Study of Anti-SARS-CoV-2 Plasma in Hospitalized Patients with COVID-19	India	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=42751">CTRI/2020/05/025319</a>	Angiotensin Receptor Blocker Losartan for prevention of COVID 19 complications: a randomized placebo controlled trial - LICCI	India	Y	N	Drug Repurposing	Losartan	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=43703">CTRI/2020/05/025328</a>	To Assess the Safety and Efficacy of Convalescent Plasma on outcome of COVID-19 Associated Complications - COVID PLASMA STUDY	India	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Mortality	Severe Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=43005">CTRI/2020/05/025346</a>	A Phase II, Open Label, Randomized Controlled Trial to Assess the Safety and Efficacy of Convalescent Plasma in Severe Covid-19 patients.	India	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=43485">CTRI/2020/05/025369</a>	A Multi-center, Randomized Controlled, Phase III Study to evaluate the Clinical Outcomes and Safety of Tocilizumab along with Standard of Care in Patients with Cytokine Release Syndrome associated with COVID-19 infection  - None	India	Y	N	Drug Repurposing	Tocilizumab	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=43076">CTRI/2020/06/025575</a>	Safety and efficacy of antiviral combination therapy in symptomatic patients of Covid-19 infection - a randomised control trial - SEV-Covid Trial	India	Y	Y	Drug Repurposing	Oseltamivir	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=44346">CTRI/2020/06/025613</a>	Melatonin For COVID 19 pre exposure prophylaxis in High Risk  population  . (MELATONIN IMMUNE BOOST COVID 19 STUDY )	India	Y	N	Drug Repurposing	Melatonin	Efficacy - Infection rate (prevention)	Other	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=44170">CTRI/2020/06/025704</a>	A Phase 3, Prospective, Randomized, Open Label, Comparative, Clinical Study To Evaluate Efficacy And Safety Of Ulinastatin Plus Standard-Of-Care Compared To Standard-Of-Care In Treatment Of Acute Respiratory Distress Syndrome (ARDS) In Hospitalized COVID-19 Infection Patient	India	Y	N	Shelved drug or NME	Ulinastatin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=44441">CTRI/2020/06/025760</a>	Efficacy of Sofosbuvir in the management of hospitalized COVID 19 patients.	India	N	N	Drug Repurposing	Sofosbuvir	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=44480">CTRI/2020/06/025799</a>	A Randomized, Open Label, Prospective, Comparative, Parallel Group, Multicentre Study To Evaluate Efficacy And Safety Of Favipiravir With Supportive Care Versus Supportive Care Alone In Subjects With Mild To Moderate Coronavirus Disease (COVID-19).  - NA	India	Y	N	Drug Repurposing	Favipiravir	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=44478">CTRI/2020/06/025803</a>	Efficacy of Convalescent Plasma Therapy in Patients With COVID-19: A Randomized Control Trial	India	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - WHO scale	Severe Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=44408">CTRI/2020/06/025849</a>	A Randomized, Open Label, 2-Treatment Groups Clinical Trial Evaluating the Safety and Efficacy of a Combination of Nitazoxanide and Hydroxychloroquine Versus Hydroxychloroquine Alone in the Acute Treatment of Moderate COVID-19 Patients	India	Y	N	Drug Repurposing	Nitazoxanide	Efficacy - Viral load	Mild/Moderate Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=44078">CTRI/2020/06/025854</a>	Study to Evaluate the Effectiveness of BCG vaccine in Reducing Morbidity and Mortality in Elderly individuals in COVID-19 Hotspots in India - BCG for COVID-19	India	N	N	Vaccine	Vaccine	Efficacy - WHO scale	Other	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=44664">CTRI/2020/06/025928</a>	Povidone Iodine Gargle and Intranasal application: A Quasi-Experimental study to reduce the spread of coronavirus infection in community with Covid-19 positive clusters.	India	N	N	Shelved drug or NME	Povidone-Iodine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=44709">CTRI/2020/06/025957</a>	A Randomized Open-Label Study To Evaluate The Efficacy And Safety Of Favipiravir And Umifenovir As Compared To Favipiravir Alone In Moderate Hospitalized Adult Indian COVID-19 Patients.	India	Y	N	Drug Repurposing	Umifenovir	Efficacy - WHO scale	Mild/Moderate Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=44196">CTRI/2020/06/026001</a>	Randomised Controlled Trial of Ivermectin in hospitalised patients with COVID19 - RIVET-COV	India	Y	N	Drug Repurposing	Ivermectin	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=43775">CTRI/2020/06/026087</a>	A phase II, randomized, controlled, open-label study to evaluate the efficacy and safety of Pegylated IFN alfa-2b in the treatment of adult patients diagnosed with SARS-CoV2 (COVID-19).	India	Y	N	Drug Repurposing	Interferon alpha-2b	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=44667">CTRI/2020/06/026123</a>	A phase II, Open label, randomized controlled trial to assess the safety and efficacy of convalescent plasma in severe COVID-19. - PLATINA TRIAL.	India	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - WHO scale	Severe Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=45027">CTRI/2020/06/026187</a>	Phase II, open label, randomized controlled trial to evaluate Safety and Efficacy of ACT12 Tablet and ACT 13 dry syrup as an immunomodulator in adult Covid 19 positive patients - Nil	India	Y	N	Shelved drug or NME	ACT12, ACT13	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=45029">CTRI/2020/06/026189</a>	Randomized, Double Blind, Parallel Group Study of Vitamin D3 & Magnesium in Covid 19 Infection - Covid	India	Y	N	Drug Repurposing	Vitamin D, Magnesium	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=45075">CTRI/2020/06/026191</a>	Randomized, Double Blind, Comparative, Parallel  group  study of Vitamin D3  ( Cholecalciferol )   Vitamin K2-7 & magnesium  in prophylaxis of   COVID-19 infection  in  health care professionals - Covid19	India	Y	N	Drug Repurposing	Vitamin K, Magnesium	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=44815">CTRI/2020/06/026192</a>	A randomised, double-blind, placebo-controlled, phase 2 trial investigating the safety and efficacy of C21 in hospitalised subjects with COVID-19 infection not requiring mechanical ventilation - The ATTRACT Trial	India	Y	N	Shelved drug or NME	C21	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=44766">CTRI/2020/06/026193</a>	A randomized control study to evaluate the therapeutic effects of Lithium in Covid-19 patients	India	Y	N	Drug Repurposing	Lithium	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=44299">CTRI/2020/06/026222</a>	A Phase II Safety and Efficacy Study on prognosis of Moderate Pneumonia in COVID-19 patients with Regular Intravenous Immunoglobulin Therapy	India	Y	N	Cell/Blood based	Immunoglobulin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=44350">CTRI/2020/06/026220</a>	An Open Label, Randomized, Multicenter, Controlled Clinical Study to Evaluate the Efficacy and Safety of Nafamostat Mesilate in the Treatment of Moderate COVID-19 Disease	India	Y	N	Drug Repurposing	Nafamostat	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=45156">CTRI/2020/06/026232</a>	A Clinical Trial to Study the Efficacy of    ??Ivermectin  ??  in the prevention of Covid-19. .A Single Arm Study.   ??	India	N	N	Drug Repurposing	Ivermectin	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=44929">CTRI/2020/07/026340</a>	Prospective study to assess therapeutic role of Zinc in COVID-19 patients	India	Y	N	Drug Repurposing	Zinc	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="http://www.ctri.nic.in/Clinicaltrials/pmaindet2.php?trialid=45306">CTRI/2020/07/026352</a>	A prospective, randomized, adaptive, phase I/II clinical study to evaluate the safety and immunogenicity of Novel Corona Virus -2019-nCov vaccine candidate of M/s Cadila Healthcare Limited by intradermal route in healthy subjects	India	Y	N	Vaccine		Safety	Other	
<a href="https://anzctr.org.au/ACTRN12620000731998.aspx">ACTRN12620000731998</a>	Safety and efficacy of a pharmacological strategy using Losartan in hospital patients with COVID-19	Australia	N	N	Drug Repurposing	Losartan	Safety	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=55775">ChiCTR2000034796</a>	the efficacy and safety of heparin in the treatment of novel coronavirus pneumonia (COVID-19): a prospective, randomized, controlled trial	China	N	N	Drug Repurposing	LMWH	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=56651">ChiCTR2000034780</a>	Randomized, Double Blind, Parallel Placebo Controlled, Phase III Clinical Trial to Evaluate the Safety and Protective Efficacy of Inactivated SARS-CoV-2 Vaccine in Healthy Population Aged 18 Years and above	United Arab Emirates	Y	Y	Vaccine	ND:Vero cell vaccine	Efficacy - Infection rate (prevention)	General population	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=56834">ChiCTR2000034825</a>	Safety and Immunogenicity of SARS-CoV-2 mRNA Vaccine (BNT162b1) in Chinese Healthy Subjects: A Phase I, Randomized, Placebo-controlled, Observer-blind Study	China	N	N	Shelved drug or NME	BNT162b1	Safety	Other	
<a href="https://anzctr.org.au/ACTRN12620000588998.aspx">ACTRN12620000588998</a>	The safety and efficacy of STC3141 in patient with COVID-19 ARDS require intensive care	Australia	Y	N	Shelved drug or NME	STC3141	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://anzctr.org.au/ACTRN12620000566932.aspx">ACTRN12620000566932</a>	BEAT COVID-19: A Bayesian adaptive randomised controlled trial platform to evaluate the efficacy of interventions for high risk older patients with COVID-19 in reducing the risk of hospital admission or death.	Australia	Y	N	Drug Repurposing	<TBC>	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://anzctr.org.au/ACTRN12620000674932.aspx">ACTRN12620000674932</a>	A Phase 1 Randomised, Double-Blind, Placebo-Controlled, Dosage-Escalation, Single Centre Study To Evaluate The  Safety And Immunogenicity  Of An Adjuvanted SARS-CoV-2 Sclamp Protein Subunit Vaccine (COVID-19 vaccine) In Healthy Adults Aged 18 To 55 Years Old	Australia	Y	N	Shelved drug or NME	SARS-CoV-2 Sclamp Protein Subunit Vaccine	Safety	Other	
<a href="http://isrctn.com/ISRCTN14326006">ISRCTN14326006</a>	Protecting frontline health care workers from COVID-19 with hydroxychloroquine pre-exposure prophylaxis: a randomized, placebo-controlled multi-site trial in Toronto, Canada	Canada	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="http://isrctn.com/ISRCTN48734830">ISRCTN48734830</a>	RAAS blockagE in SARS COV-2 Critically ill patiEnts    a Randomized controlled trial	Sweden	Y	N	Drug Repurposing	Losartan	Efficacy - Other efficacy	Severe Cases	
<a href="http://isrctn.com/ISRCTN89951424">ISRCTN89951424</a>	A phase III randomized controlled trial to determine safety, efficacy, and immunogenicity of the non-replicating ChAdOx1 nCoV-19 vaccine	United Kingdom	Y	N	Vaccine	ND:ChAdOx1 vaccine	Efficacy - Infection rate (prevention)	Other	
<a href="http://isrctn.com/ISRCTN59048638">ISRCTN59048638</a>	Sulodexide in the treatment of early stages of COVID-19	Mexico	Y	N	Drug Repurposing	Sulodexide	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="http://isrctn.com/ISRCTN17072692">ISRCTN17072692</a>	A first-in-human clinical trial to assess the safety and immunogenicity of a self-amplifying ribonucleic acid (saRNA) vaccine encoding the S glycoprotein of SARS-CoV-2, the causative agent of COVID-19	United Kingdom	Y	N	Vaccine	ND:Vaccine	Safety	General population	
<a href="http://isrctn.com/ISRCTN83971151">ISRCTN83971151</a>	An international randomized trial of additional treatments for COVID-19 in hospitalized patients who are all receiving the local standard of care	Switzerland	Y	Y	Drug Repurposing	Remdesivir, Chloroquine, Hydroxychloroquine, Lopinavir/ritonavir, Interferon beta	Efficacy - WHO scale	General population, Severe Cases	
<a href="https://trialregister.nl/trial/8523">NL8523</a>	Volatile agents for sedation in patients with COVID-19-associated acute respiratory distress syndrome     a pilot study	Netherlands	N	N	Drug Repurposing	Isoflurane	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://trialregister.nl/trial/8578">NL8578</a>	Alkaline phosphatase for reducing systemic inflammatory response syndrome (SIRS) in patients with Sars-CoV-2 infection and acute respiratory insufficiency (COVID 19)	Netherlands	N	N	Drug Repurposing	Alkaline phosphatase	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://trialregister.nl/trial/8609">NL8609</a>	Enhancing the BCG-induced trained immunity response by addition of bisphosphonate or MMR vaccine: a possible preventive approach against COVID-19 (BCG-PLUS)	Netherlands	Y	N	Drug Repurposing, Vaccine	ND:BCG vaccine, Bisphosphonate, ND:MMR vaccine	Efficacy - Other efficacy	General population	
<a href="https://trialregister.nl/trial/8633">NL8633</a>	Convalescent plasma compared to standard plasma for treatment of hospitalized non-ICU patients with COVID-19 infections	Netherlands	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://trialregister.nl/trial/8726">NL8726</a>	Randomized, placebo-controlled multiple dose study to evaluate the effect of hydroxychloroquine on the general immuno-competence in young and elderly healthy male volunteers	Netherlands	N	N	Drug Repurposing	Hydroxychloroquine	Other	Other	
<a href="https://trialregister.nl/trial/8490">NL8490</a>	An open label randomized controlled trial of chloroquine, hydroxychloroquine or only supportive care in patients admitted with moderate to severe COVID-19	Netherlands	Y	Y	Drug Repurposing	Chloroquine, Hydroxychloroquine	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="http://www.drks.de/DRKS00021573">DRKS00021573</a>	Impact of pantoprazole on absorption and disposition of hydroxychloroquine, a drug used in Covid-19 - K724_HCQ-PPI	Germany	Y	N	Drug Repurposing	Pantoprazole	Other	General population	
<a href="http://www.drks.de/DRKS00021214">DRKS00021214</a>	Improvement of the nutritional status regarding nicotinamide (vitamin B3) and the course of COVID-19 disease - COVit	Germany	Y	N	Drug Repurposing	Nicotinamide	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="http://www.drks.de/DRKS00022203">DRKS00022203</a>	Efficacy & Safety of Sofosbuvir/Daclatasvir treatment in COVID-19: A randomized, controlled study	Egypt	Y	Y	Drug Repurposing	Sofosbuvir, Daclatasvir, Hydroxychloroquine	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://rpcec.sld.cu/en/trials/RPCEC00000306-En">RPCEC00000306</a>	Randomized control clinical trial of CIGB 2020 in contacts and SARS-CoV-2 infection suspects (COVID-19)	Cuba	Y	N	Shelved drug or NME	CIGB 2020 vaccine	Efficacy - Other efficacy	Exposed individuals (family members, HCP)	
<a href="https://rpcec.sld.cu/en/trials/RPCEC00000307-En">RPCEC00000307</a>	Evaluation of the effect and safety of HeberFERON versus Heberon alfa in patients infected with the SARS-CoV-2 coronavirus (COVID-19).	Cuba	Y	N	Drug Repurposing	Interferon Alpha Gamma	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://rpcec.sld.cu/en/trials/RPCEC00000308-En">RPCEC00000308</a>	Pharmacodynamics and safety of recombinant interferon alfa 2b, by different routes of administration, in healthy volunteers (COVID-19).	Cuba	Y	Y	Drug Repurposing	Interferon alpha-2b	Other	General population	
<a href="https://rpcec.sld.cu/en/trials/RPCEC00000309-En">RPCEC00000309</a>	Evaluation of the effect of 0.002% sodium chloride saline (activated) administered intravenously and / or mists in patients with covid-19. (COVID-19) - TX-COVID19	Mexico	Y	N	Drug Repurposing	Sodium chloride	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://rpcec.sld.cu/en/trials/RPCEC00000311-En">RPCEC00000311</a>	Treatment of patients with severe SARS-CoV-2 pneumonia with the anti-CD6 monoclonal antibody itolizumab. (COVID-19) - VICTORIA	Cuba	N	N	Drug Repurposing	Itolizumab	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://rpcec.sld.cu/en/trials/RPCEC00000313-En">RPCEC00000313</a>	Administration of the CIGB-258 peptide in patients with COVID-19 under intensive therapy regimen (COVID-19)	Cuba	N	N	Shelved drug or NME	CIGB-258	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://rpcec.sld.cu/en/trials/RPCEC00000314-En">RPCEC00000314</a>	Population impact of intervention based on the administration of a single dose of the Outer Membrane Vesicle (OMV) complex contained in VA-MENGOC-BC to stimulate the innate response against SARS-CoV-2 (COVID-19) - VME-CORONA	Cuba	N	N	Vaccine	ND:Vaccine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://rpcec.sld.cu/en/trials/RPCEC00000315-En">RPCEC00000315</a>	Evaluation of the synergistic effect of  sequential administration of two immunostimulant products: Immuno-1 and Immuno-2 for the stimulation of the immune response in older adults. Exploratory study (COVID-19) - InmunoCorona	Cuba	Y	N	Shelved drug or NME	Immuno-1, Immuno-2	Other	Other	
<a href="https://rpcec.sld.cu/en/trials/RPCEC00000316-En">RPCEC00000316</a>	Evaluation of the effect and safety of BIOMODULIN T(R) for the stimulation of the immune response in patients with Stage 5 Chronic Kidney Disease under an iterated hemodialysis regimen. Exploratory study. (COVID-19)	Cuba	Y	N	Shelved drug or NME	Biomodulin T	Efficacy - Other efficacy	Other	
<a href="https://rpcec.sld.cu/en/trials/RPCEC00000317-En">RPCEC00000317</a>	Application of the CIGB 300 as Antiviral in the treatment of patients with a diagnosis of Covid 19. (COVID-19)	Cuba	Y	N	Shelved drug or NME	CIGB 300	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://rpcec.sld.cu/en/trials/RPCEC00000321-En">RPCEC00000321</a>	Expanded clinical use of CIGB-258 in the treatment of serious or critically ill patients by COVID-19 (COVID-19)	Cuba	N	N	Shelved drug or NME	CIGB-258	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://jrct.niph.go.jp/latest-detail/jRCTs031190269">JPRN-jRCTs031190269</a>	A multicenter, open-label, randomized controlled phase II study to evaluate the efficacy and safety of inhaled ciclesonide for asymptomatic and mild patients with COVID-19 - RACCO trial	Japan	Y	N	Drug Repurposing	Ciclesonide	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001783-28/HU">2020-001783-28</a>	REDUCING ABSENCE FROM WORK OF HEALTHCARE WORKERS DUE TO COVID-19 INFECTION BY BCG (BACILLUS CALMETTE-GU&Eacute;RIN) VACCINATION	Hungary	Y	N	Vaccine	BCG vaccine	Efficacy - Other efficacy	Exposed individuals (family members, HCP)	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001459-42/DK">2020-001459-42</a>	Ruxolitinib Treatment in Patients with Severe COVID-19 Infection. A Danish Safety and Efficacy Study.	Denmark	N	N	Drug Repurposing	Ruxolitinib	Efficacy - Mortality	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001194-69/ES">2020-001194-69</a>	Pilot study to evaluate the efficacy and safety of mefloquine as prophylaxis in people exposed to the disease caused by the SARS-CoV-2 coronavirus (COVID-19)	Spain	Y	N	Drug Repurposing	Mefloquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-002123-11/ES">2020-002123-11</a>	RANDOMIZED CLINICAL TRIAL OF PARALLEL GROUPS TO COMPARE THE EFFICACY OF HYDROXYCHLOROQUINE VS. CYCLOSPORINE - HYDROXYCHLOROQUINE IN THE TREATMENT OF COVID-19 PNEUMONIA.	Spain	Y	N	Drug Repurposing	Cyclosporine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001678-31/FR">2020-001678-31</a>	Randomized controlled trial evaluating the efficacy of vaccination with Bacillus Calmette and Gu&eacute;rin (BCG) in the Prevention of COVID-19 via the strengthening of innate immunity in Health Care Workers.&rdquo;&#13; COVID-BCG&#13;	France	Y	N	Vaccine	BCG Vaccine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001527-14/NL">2020-001527-14</a>	COVID-19: addition of azithromycin to chloroquine treatment	Netherlands	Y	N	Drug Repurposing	Azithromycin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001888-90/DK">2020-001888-90</a>	Using BCG vaccine to enhance non-specific protection of health care workers during the COVID-19 pandemic. A randomised controlled multi-center trial.	Denmark	Y	N	Vaccine	BCG vaccine	Efficacy - Other efficacy	Exposed individuals (family members, HCP)	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001421-31/ES">2020-001421-31</a>	Clinical trial randomized, unblinded and controled for evaluation of efficacy and safety of hydroxychloroquine chemoprophylaxis against SARS-CoV-2 (COVID-19) infection in healthcare professionals.	Spain	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001546-19/BE">2020-001546-19</a>	A First-in-Human Study in Adult Subjects Hospitalized with Covid-19 to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, Immunogenicity and Efficacy of ARGX-117	Belgium	N	N	Shelved drug or NME	ARGX-117	Safety	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-002027-10/SE">2020-002027-10</a>	A prospective, multicenter, randomized PHASE II clinical trial of enzalutamide treatment to decrease the morbidity in patients with Corona virus disease 2019 (COVID-19)	Sweden	Y	N	Drug Repurposing	Enzalutamide	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001697-30/ES">2020-001697-30</a>	PRE-EXPOSURE PROPHYLAXIS WITH HYDROXYCHLOROQUINE IN SANITARIES HIGHLY EXPOSED TO COVID-19. (COVIDNA)	Spain	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Other efficacy	Exposed individuals (family members, HCP)	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001686-36/FR">2020-001686-36</a>	A double-blind, randomized study versus placebo of avdoralimab (IPH5401), an anti-C5aR antibody, in patients with COVID-19 induced pneumonia&#13;	France	Y	N	Shelved drug or NME	Avdoralimab	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001417-21/BE">2020-001417-21</a>	An open label single center randomized controlled trial to evaluate the effect of hydroxychloroquine on viral shedding in mild COVID-19	Belgium	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001440-26/ES">2020-001440-26</a>	Pilot, double-blind clinical trial to evaluate the efficacy and safety of pre-exposure use of hydroxychloroquine versus placebo in the prevention of SARS-CoV-2 (COVID-19) infection in healthcare personnel.	Spain	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001987-28/IT">2020-001987-28</a>	PRECOV: a randomized controlled clinical trial on the effects of hydroxychloroquine in the prevention of COVID-19 in healthcare workers at risk	Italy	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-002449-41/ES">2020-002449-41</a>	Pilot trial on early treatment with hydroxychloroquine in patients with&#13; COVID-19 who do not have hospital admission at diagnosis.	Spain	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001327-13/AT">2020-001327-13</a>	A SINGLE-BLINDED RANDOMIZED, PLACEBO-CONTROLLED PHASE II TRIAL OF PROPHYLACTIC TREATMENT WITH ORAL AZITHROMYCIN VERSUS PLACEBO IN CANCER PATIENTS UNDERGOING ANTINEOPLASTIC TREATMENT DURING THE COVID-19 PANDEMIC	Austria	N	N	Drug Repurposing	Azithromycin	Efficacy - Infection rate (prevention)	Other	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001994-66/ES">2020-001994-66</a>	Ramdomised clinical trial of ivermectin for treatment and prophylaxis of COVID-19	Spain	Y	N	Drug Repurposing	Ivermectin	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP), Mild/Moderate Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-002233-15/DE">2020-002233-15</a>	A randomized, single blind, placebo-controlled, parallel-arm study to investigate the safety and preliminary efficacy of Niclosamide and Camostat alone and in combination to treat Covid-19 (&ldquo;NICCAM&rdquo;)	Germany	Y	Y	Drug Repurposing	Niclosamide, Camostat	Safety	Mild/Moderate Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001777-71/GB">2020-001777-71</a>	Ruxolitinib therapy to Avoid Ventilation and improve outcome for deteriorating COVID-19 patiENts - RAVEN	United Kingdom	N	N	Drug Repurposing	Ruxolitinib	Efficacy - Other efficacy	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001740-26/GB">2020-001740-26</a>	A multi-centre open-label two-arm randomised superiority clinical trial of Azithromycin versus usual care In Ambulatory COVID-19 (ATOMIC2)	United Kingdom	Y	N	Drug Repurposing	Azithromycin	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001803-17/GB">2020-001803-17</a>	A Phase 2/3 Single-Arm, Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of Remdesivir (GS-5734&trade;) in Participants from Birth to &lt; 18 Years of Age with COVID-19	United Kingdom	N	N	Shelved drug or NME	Remdesivir	Safety	Mild/Moderate Cases, Severe Cases, Other	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001618-39/ES">2020-001618-39</a>	A Phase II, randomized, open&ndash;label study to evaluate the efficacy and tolerability of treatment with vafidemstat in combination with standard of care treatment to prevent Acute Respiratory Distress Syndrome (ARDS) in adult severely ill patients with COVID-19.	Spain	Y	N	Drug Repurposing	Vafidemstat	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-002091-12/BG">2020-002091-12</a>	Multicenter, randomized, double-blind, placebo-controlled study investigating efficacy, safety and tolerability of ivermectin HUVE-19 in patients with proven SARS-CoV-2 infection (COVID-19) and manifested clinical symptoms.	Bulgaria	Y	N	Drug Repurposing	Ivermectin	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-002211-21/GB">2020-002211-21</a>	A Phase II, randomised, double-blind, placebo-controlled clinical trial to assess the safety and efficacy of AZD1656 in diabetic patients hospitalised with suspected or confirmed COVID-19. The ARCADIA Trial	United Kingdom	Y	N	Shelved drug or NME	AZD1656	Efficacy - WHO scale	Other	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001448-24/GB">2020-001448-24</a>	Preventing Pulmonary Complications in Surgical Patients at Risk of COVID-19	United Kingdom	Y	Y	Drug Repurposing	Hydroxychloroquine, Ritonavir/lopinavir	Efficacy - Other efficacy	General population	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001750-22/GB">2020-001750-22</a>	MATIS: Phase 2/3, Randomised, Open-Label, Single-Site, Multi-Arm Trial of Ruxolitinib Plus Best Supportive Treatment (BST) versus Fostamatinib Plus BST versus BST for COVID-19 pneumonia	United Kingdom	Y	Y	Drug Repurposing	Ruxolitinib, Fostamatinib	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001721-31/GB">2020-001721-31</a>	Can a sinus rinse and mouth wash reduce viral load in COVID-19 positive individuals?	United Kingdom	Y	N	Shelved drug or NME	iodonated Povidone	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001296-33/DK">2020-001296-33</a>	Efficacy and safety of 72-hour infusion of Prostacyclin (1 ng/kg/min) in patients with COVID-19 induced respiratory failure &ndash; a multicentre randomized, placebo-controlled, blinded, investigator-initiated trial	Denmark	Y	N	Drug Repurposing	Iloprost	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001671-32/ES">2020-001671-32</a>	A multi-center, open-label, randomized parallel controlled evaluation on the efficacy and safety of BDB-001 injection in the treatment of progressive severe COVID-19 in phase II	Spain	Y	N	Shelved drug or NME	BDB-001	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001605-23/ES">2020-001605-23</a>	Effectiveness of the combined treatment with hydroxycloroquine and azithromycin vs lopinavir/ritonavir + hydroxycloroquine in hospitalized patients with confirmed COVID-19 infection	Spain	Y	N	Drug Repurposing	Hydroxychloroquine, Azithromycin	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-002472-12/NL">2020-002472-12</a>	Lanadelumab for treatment of COVID-19 disease	Netherlands	Y	N	Drug Repurposing	Lanadelumab	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001921-30/IT">2020-001921-30</a>	Steroids and unfractionated heparin in critically-ill patients with pneumonia from COVID-19 infection. A multicenter, interventional, randomized, three arms study design.	Italy	Y	N	Drug Repurposing	Methylprednisolone	Efficacy - Mortality	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001929-31/ES">2020-001929-31</a>	Controlled, randomized, non-blind trial on the usefulness of pioglitazone treatment in patients with type 2 diabetes mellitus and COVID-19.	Spain	Y	N	Drug Repurposing	Pioglitazone	Efficacy - Clinical improvement (except WHO scale)	Other	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001308-40/IT">2020-001308-40</a>	Intermediate dose enoxaparin in hospitalized patients with moderate-severe COVID-19: a pilot phase II single-arm study, INHIXACOVID19	Italy	N	N	Drug Repurposing	Enoxaparin	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001587-29/ES">2020-001587-29</a>	Hydroxychloroquine efficacy in preventing SARS-CoV-2 infection and CoVid-19 disease severity during pregnancy	Spain	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Viral load	Exposed individuals (family members, HCP), Mild/Moderate Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001995-13/ES">2020-001995-13</a>	A multicentre, open-label clinical trial to evaluate the effectiveness and safety of intravenous tocilizumab for treating patients with COVID-19 pneumonia: the BREATH-19 Study	Spain	Y	N	Drug Repurposing	Tocilizumab	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-002120-37/GB">2020-002120-37</a>	An open-label, adaptive randomized, controlled multicenter study to evaluate the efficacy and safety of RESP301 plus standard of care (SOC) compared to SOC alone in hospitalized participants with COVID-19 requiring supplemental oxygen (NOCoV2)	United Kingdom	Y	N	Shelved drug or NME	RESP301	Efficacy - WHO scale	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001904-41/GB">2020-001904-41</a>	Glasgow Early Treatment Arm FavIpiravir? : A randomized controlled study of favipiravir as an early treatment arm in COVID-19 patients	United Kingdom	Y	N	Drug Repurposing	Favipiravir	Efficacy - WHO scale	Mild/Moderate Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001765-37/ES">2020-001765-37</a>	Pragmatic clinical trial to evaluate the efficacy of hydroxychloroquine in the treatment of COVID-19 infection in two cohorts: patients with oncohaematological disease and SARS-CoV-2 positive without radiological alteration and sars-cov-2 positive professionals without radiological alteration	Spain	N	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Clinical improvement (except WHO scale)	Other	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001635-27/FR">2020-001635-27</a>	A Phase 2, Randomized, Open-label Clinical Trial comparing the Safety and Efficacy of Hydroxychloroquine, and Standard of Care to a Combination of Masitinib, Isoquercetin, and Standard of Care for the Treatment of Hospitalized Moderate and Severe COVID-19 Patients.	France	Y	N	Drug Repurposing	Masitinib, Isoquercetin	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001536-98/ES">2020-001536-98</a>	Prophylaxis of COVID-19 infection with hydroxychloroquine in healthcare&#13; personnel with high risk of infection.	Spain	N	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001270-29/GB">2020-001270-29</a>	An adaptive Phase 2/3, randomized, open-label study assessing efficacy and safety of hydroxychloroquine for hospitalized patients with moderate to severe COVID-19	United Kingdom	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001386-37/IT">2020-001386-37</a>	Uno studio randomizzato multicentrico in aperto per valutare l&rsquo;efficacia della somministrazione precoce del Tocilizumab (TCZ) in pazienti affetti da polmonite da COVID-19.	Italy	Y	N	Drug Repurposing	Tocilizumab	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001603-16/ES">2020-001603-16</a>	A RANDOMIZATION, MULTICENTRIC, OPEN-LABEL, CONTROLLED, CLINICAL TRIAL TO INVESTIGATE THE EFFECTIVENESS OF EARLY CHOLCHICINE ADMINISTRATION IN PATIENTS OVER 70 YEARS OF AGE WITH HIGH RISK OF DEVELOPING SEVERE PULMONARY COMPLICATIONS ASSOCIATED WITH CORONAVIRUS SARS-CoV2 PNEUMONIA (COVID-19)	Spain	Y	N	Drug Repurposing	Colchicine	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001502-38/GB">2020-001502-38</a>	A randomised, double blind, placebo controlled, Phase 2 trial investigating the safety and efficacy of C21 in hospitalised subjects with COVID-19 infection not requiring mechanical ventilation	United Kingdom	Y	N	Shelved drug or NME	C21	Other	Mild/Moderate Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001704-42/ES">2020-001704-42</a>	Controlled and randomised trial to assess the safety and efficacy of hydroxychloroquine chemoprophylaxis in SARS CoV2 infection in hospital healthcare personnel (Sanitarios sin COVID-19 -SANsinCOVID-19).	Spain	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001841-38/ES">2020-001841-38</a>	Colchicine for the Treatment of Hyperinflammation associated with Pneumonia due to COVID-19&#13;	Spain	Y	N	Drug Repurposing	Colchicine	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001492-33/FR">2020-001492-33</a>	Interest in the administration of Dornase alpha aerosol in ARDS secondary to respiratory infection by the coronavirus SRASCoV-2 / COVID-19	France	Y	N	Drug Repurposing	Dornase alfa	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001766-11/FR">2020-001766-11</a>	Losartan and spironolactone treatment for COVID-19 patients with acute respiratory failure in intensive care unit	France	Y	N	Drug Repurposing	Losartan, Spironolactone	Efficacy - Other efficacy	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001808-42/ES">2020-001808-42</a>	PHASE II CLINICAL TRIAL, SINGLE-BLIND, RANDOMIZED, PLACEBO CONTROLLED TO EXPLORE THE EFFECTIVENESS AND SAFETY OF MELATONIN I.V. IN PATIENTS WITH COVID-19 ENTERED INTO THE ICU (MELCOVID STUDY)	Spain	Y	N	Drug Repurposing	Melatonin	Efficacy - Mortality	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001209-22/GB">2020-001209-22</a>	Platform Randomised trial of INterventions against COVID-19 In older peoPLE	United Kingdom	Y	N	Drug Repurposing	Hydroxychloroquine, Azithromycin	Efficacy - Other efficacy	General population	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001445-39/ES">2020-001445-39</a>	PRAGMATIC, CONTROLLED, OPEN, SINGLE CENTER, RANDOMIZED, PHASE II CLINICAL TRIAL TO EVALUATE METHYLPREDNISOLONE PULSES AND TACROLIMUS IN HOSPITALIZED PATIENTS WITH SEVERE PNEUMONIA SECONDARY TO COVID-19 (TACROVID)	Spain	Y	N	Drug Repurposing	Methylprednisolone, Tacrolimus	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001807-18/GB">2020-001807-18</a>	A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Parallel-group, Multi-center Study of an Inhaled Pan-Janus Kinase Inhibitor, TD-0903, to Treat Symptomatic Acute Lung Injury Associated with COVID-19	United Kingdom	Y	N	Shelved drug or NME	TD-0903	Safety	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001682-36/ES">2020-001682-36</a>	Double-blind, placebo-controlled phase I/II clinical trial to evaluate the safety and efficacy of allogeneic mesenchymal stem cells (MSV&reg;-allo) in acute respiratory failure in patients with COVID-19 pneumonia.&#13;	Spain	Y	N	Cell/Blood based	ND:Stem cells	Efficacy - Other efficacy	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001367-88/DK">2020-001367-88</a>	Efficacy and safety of novel treatment options for adults with COVID-19 pneumonia. A double-blinded, randomized, multi-stage, 6-armed placebo-controlled trial in the framework of an adaptive trial platform	Denmark	Y	Y	Drug Repurposing, Cell/Blood based	Hydroxychloroquine, Baricitinib, Sarilumab, ND:Convalescent plasma	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-002032-69/ES">2020-002032-69</a>	Single-center, randomized, open-label clinical trial on the efficacy of tocilizumab in modifying the inflammatory parameters of patients with COVID-19	Spain	Y	N	Drug Repurposing	Tocilizumab	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001640-26/GB">2020-001640-26</a>	A pilot, open label, phase II clinical trial of nebulised recombinant tissue-Plasminogen Activator (rtPA)in patients with COVID-19 ARDS: The Plasminogen Activator COVID-19 ARDS (PACA) trial	United Kingdom	N	N	Drug Repurposing	Alteplase	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-002111-22/PL">2020-002111-22</a>	A multi-centre, randomised, double-blind, placebo-controlled phase III study assessing the impact of BCG vaccination on the incidence and course of SARS-CoV-2 infection among healthcare workers in Poland during the COVID-19 pandemic.	Poland	Y	N	Vaccine	ND:Vaccine	Efficacy - Mortality	Exposed individuals (family members, HCP)	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-002186-34/ES">2020-002186-34</a>	Efficacy of the early use of corticotherapy in CoV-2 infection to prevent the progression of acute respiratory distress syndrome (ARDS) in COVID-19	Spain	N	N	Drug Repurposing	Methylprednisolone	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-002476-13/GB">2020-002476-13</a>	A study to assess the safety and efficacy of Clazakizumab in patients with COVID-19 and kidney disease.	United Kingdom	N	N	Shelved drug or NME	Clazakizumab	Efficacy - Other efficacy	Other	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001469-35/PL">2020-001469-35</a>	A multicenter, open, randomized, non-commercial study to evaluate the efficacy and safety of chloroquine phosphate in the outpatient treatment of COVID-19 in combination with telemedicine care for patients with SARS-CoV-2 infection with the risk of developing complications to reduce the risk of COVID-19-related hospitalization and death.	Poland	Y	N	Drug Repurposing	Chloroquine	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001805-21/GB">2020-001805-21</a>	Prospective, Randomized, Parallel-Group, Open-Label Study to Evaluate the Efficacy and Safety of IMU-838, in Combination with Oseltamivir, in Adults with Coronavirus Disease COVID-19	United Kingdom	Y	N	Shelved drug or NME	IMU-838	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001250-21/FR">2020-001250-21</a>	COVID-19 - Epidemiology of SARS-CoV-2 and Mortality to Covid19 Disease upon Hydroxychloroquine and Azithromycin Therapy in French Cancer patients	France	N	N	Drug Repurposing	Hydroxychloroquine, Azithromycin	Efficacy - Clinical improvement (except WHO scale)	Other	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001437-12/ES">2020-001437-12</a>	Random, controlled, open, one-site clinical trial in adult patients with COVID-19 severe pneumonia treated with immunomodulatory drugs	Spain	Y	Y	Drug Repurposing	Cyclosporine, Tocilizumab	Efficacy - Mortality	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001659-42/ES">2020-001659-42</a>	Pilot study of antithrombin as prophylaxis of acute respiratory distress syndrome in patients with COVID-19	Spain	Y	N	Cell/Blood based	ND:Human antithrombin	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001882-36/GR">2020-001882-36</a>	ANTI-INFLAMMATORY CLARITHROMYCIN TO IMPROVE SARS-CoV-2 (COVID-19) INFECTION EARLY: THE ACHIEVE OPEN-LABEL NON-RANDOMIZED CLINICAL TRIAL	Greece	N	N	Drug Repurposing	Clarithromycin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001474-29/ES">2020-001474-29</a>	Pilot study to evaluate the potential of ivermectin to reduce COVID-19 transmission	Spain	Y	N	Drug Repurposing	Ivermectin	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001643-13/GB">2020-001643-13</a>	A randomised double-blind placebo-controlled trial of Brensocatib (INS1007) in patients with severe COVID-19	United Kingdom	Y	N	Shelved drug or NME	Brensocatib	Efficacy - WHO scale	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001825-29/ES">2020-001825-29</a>	CLINICAL TRIAL OF THE USE OF ANAKINRA (ANTI IL-1) IN CYTOKINE STORM SYNDROME (CSS) SECONDARY TO COVID-19	Spain	Y	N	Drug Repurposing	Anakinra	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001606-33/ES">2020-001606-33</a>	Randomized clinical trial to evaluate the efficacy of hydroxychloroquine associated or not with azithromycin as a treatment for COVID-19 infection.	Spain	Y	N	Drug Repurposing	Hydroxychloroquine, Azithromycin	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001243-15/BE">2020-001243-15</a>	Covid-19: A randomized, open-label, adaptive, proof-of- concept clinical trial of new antiviral drug candidates against SARS-CoV-2.	Belgium	Y	N	Drug Repurposing	Itraconazole	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001375-32/NL">2020-001375-32</a>	Pre-emptive tocilizumab in hypoxic COVID-19 patients, a prospective randomized trial	Netherlands	Y	N	Drug Repurposing	Tocilizumab	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001890-56/ES">2020-001890-56</a>	Double-blind randomized placebo-controlled clinical trial to evaluate the efficacy and safety of the use of intravenous gammaglobulins in the treatment of patients with COVID-19	Spain	Y	N	Cell/Blood based	ND:Gamma globulin	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001236-10/NL">2020-001236-10</a>	COUNTER-COVID - Oral imatinib to prevent pulmonary vascular leak in COVID-19 &ndash; a randomized, single-blind, placebo controlled, clinical trial in patients with severe COVID-19 disease	Netherlands	Y	N	Drug Repurposing	Imatinib	Efficacy - Other efficacy	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001823-15/FR">2020-001823-15</a>	Evaluation of the concentration-effect relationship of enoxaparin for thromboembolic prevention in COVID-19 resuscitation patients. COV-ENOX study	France	N	N	Drug Repurposing	Enoxaparin	Efficacy - Other efficacy	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001953-36/ES">2020-001953-36</a>	A Multicenter, Randomized, Open-label, Parallel Group Pilot Study to Evaluate the Safety and Efficacy of Prolastin&reg; plus Standard Medical Treatment (SMT) versus SMT alone in Hospitalized Subjects with COVID-19.	Spain	Y	N	Drug Repurposing	Prolastin	Efficacy - Other efficacy	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001696-32/ES">2020-001696-32</a>	A Multicenter, Randomized, Open-label Parallel Group Pilot Study to Evaluate Safety and Efficacy of High Dose Intravenous Immune Globulin (IVIG) plus Standard Medical Treatment (SMT) versus SMT alone in Hospitalized Subjects with COVID-19	Spain	Y	N	Cell/Blood based	ND:Human normal immunoglobulin	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001493-29/DE">2020-001493-29</a>	Charit&eacute; trial of Cenicriviroc (CVC) treatment for COVID-19 patients	Germany	Y	N	Shelved drug or NME	Cenicriviroc	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-002274-28/ES">2020-002274-28</a>	Usefulness of vitamin D on morbidity and mortality of SARS-COV-2 virus infection (Covid-19) at the Central University Hospital of Asturias	Spain	Y	N	Drug Repurposing	Cholecalciferol	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001960-28/ES">2020-001960-28</a>	Efficacy of vitamin D treatment in patients diagnosed with pneumonia who require hospital admission and have vitamin D deficiency and a positive diagnosis for SARS-Cov-2 (COVID-19)	Spain	Y	N	Drug Repurposing	Vitamin D3	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001849-39/SE">2020-001849-39</a>	Aerosolized DNase I for the treatment of severe respiratory failure in COVID-19 - a phase 2, randomized controlled trial	Sweden	Y	N	Drug Repurposing	Dornase alfa	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001934-37/ES">2020-001934-37</a>	USE OF CORTICOSTEROIDS IN PATIENTS WITH SARS-COV2 CORONAVIRUS INFECTION (GLUCOCOVID). Pragmatic trial inserted in real practice during a pandemic COVID-19	Spain	Y	N	Drug Repurposing	Methylprednisolone	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-002293-28/SE">2020-002293-28</a>	Resolving inflammatory storm in COVID-19 patients by Omega-3 polyunsaturated fatty acids.&#13; &#13; - A single-blind, randomized, placebo-controlled feasibility study	Sweden	Y	N	Drug Repurposing	Omegaven	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001558-23/IT">2020-001558-23</a>	Hydroxychloroquine sulfate early administration in symptomatic out of hospital COVID-19 positive patients. Hydro-Stop-COVID19 Trial	Italy	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-002456-21/NL">2020-002456-21</a>	Enhancing the BCG-induced trained immunity response by addition of bisphosphonate or MMR vaccine: a possible preventive approach against COVID-19 (BCG-PLUS)	Netherlands	Y	Y	Drug Repurposing, Vaccine	MMR Vaccine, Alendronic acid	Other	General population	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001747-21/PT">2020-001747-21</a>	Impact of Montelukast as add on treatment to the novel coronavirus pneumonia (COVID-19): an investigator-initiated open labelled randomized controlled pragmatic trial	Portugal	Y	N	Drug Repurposing	Montelukast	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-002166-13/ES">2020-002166-13</a>	Randomized, open, multicenter phase II clinical trial, proof of concept, to evaluate efficacy and safety of Icatibant in hospitalized patients with SARS-COV-2 (COVID-19) without assisted ventilation compared with standard care	Spain	Y	N	Drug Repurposing	Icatibant	Safety	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-002310-41/ES">2020-002310-41</a>	Intravenous Metoprolol in Respiratory Distress Due to COVID-19: Pilot Study&#13; "MADRID-COVID"	Spain	N	N	Drug Repurposing	Metoprolol	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001770-30/BE">2020-001770-30</a>	COVID 19: Experimental use of tocilizumab (Roactemra&reg;) in severe SARS-CoV-2 related pneumonia.	Belgium	Y	N	Drug Repurposing	Tocilizumab	Efficacy - WHO scale	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001333-13/FR">2020-001333-13</a>	Dexamethasone associated with hydroxychloroquine vs. hydroxychloroquine alone for the early treatment of severe ARDS caused by COVID-19 : a randomized controlled trial	France	Y	N	Drug Repurposing	Dexamethasone	Efficacy - Mortality	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-002106-68/GB">2020-002106-68</a>	Favipiravir, lopinavir/ritonavir or combination therapy: a randomised, double blind, 2x2 factorial placebo-controlled trial of early antiviral therapy in COVID-19	United Kingdom	Y	Y	Drug Repurposing	Favipiravir, Lopinavir/ritonavir	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001854-23/IT">2020-001854-23</a>	Cumulative adaptive, multiarm, multistage and multicentre randomized clinical trial with immunotherapy for Moderate COVID-19	Italy	Y	Y	Drug Repurposing	Siltuximab, Tocilizumab, Canakinumab, Baricitinib, Methylprednisolone, Sarilumab	Efficacy - Oxygen parameters	Mild/Moderate Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001408-41/DE">2020-001408-41</a>	A prospective, randomized, double blinded placebo-controlled trial to evaluate the efficacy and safety of tocilizumab in patients with severe COVID-19 pneumonia	Germany	Y	N	Drug Repurposing	Tocilizumab	Efficacy - Other efficacy	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-002482-34/3rd">2020-002482-34</a>	Efficacy and safety of Octagam 10% therapy in COVID-19 patients with severe disease progression	United States	Y	N	Cell/Blood based	ND:Octagam	Efficacy - WHO scale	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001306-35/FR">2020-001306-35</a>	Protective role of inhaled steroids for COVID-19 infection	France	Y	N	Drug Repurposing	Budesonide, Formoterol	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001023-14/GB">2020-001023-14</a>	A randomised double-blind placebo-controlled trial to determine the safety and efficacy of inhaled SNG001 (IFNß-1a for nebulisation) for the treatment of patients with confirmed SARS-CoV-2 infection (COVID-19)	United Kingdom	Y	N	Drug Repurposing	Interferon beta-1a	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001541-39/ES">2020-001541-39</a>	Pilot study of single-dose bevacizumab as a treatment for acute respiratory distress syndrome in patients with COVID-19	Spain	N	N	Drug Repurposing	Bevacizumab	Efficacy - Mortality	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001363-85/DK">2020-001363-85</a>	COVID-19 Prophylaxis with hydroxychloroquine, Vitamin D, and Zinc supplementation in Danish nursing home residents &ndash; a randomized controlled trial	Denmark	Y	N	Drug Repurposing	Hydroxychloroquine, Zinc, Vitamin D3	Efficacy - Infection rate (prevention)	General population	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001636-95/GB">2020-001636-95</a>	Subcutaneous and Intravenous anakinra in COVID-19 Infection - Feasibility &amp; Pharmacokinetics/ Pharmacodynamics study	United Kingdom	Y	N	Drug Repurposing	Anakinra	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001767-86/IE">2020-001767-86</a>	An open-label, multi-centre, randomised trial comparing different doses of single-dose tocilizumab in adults with severe, non-critical, PCR-confirmed COVID-19 infection with evidence of progressive decline in respiratory function and evolving systemic inflammation on time to intubation, non-invasive ventilation and/or all-cause mortality	Ireland	Y	N	Drug Repurposing	Tocilizumab	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001391-15/IE">2020-001391-15</a>	A randomized double-blind placebo-controlled trial of intravenous plasma-purified alpha-1 antitrypsin for severe COVID-19 illness.	Ireland	N	N	Cell/Blood based	ND:Alpha-1 antitrypsin	Efficacy - Other efficacy	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001364-29/ES">2020-001364-29</a>	Phase I/II clinical trial to evaluate the safety and efficacy of Allogenic Adipose Tissue-Derived Mesenchymal Stem Cells Expanded in patients with severe COVID-19 pneumonia	Spain	Y	N	Cell/Blood based	ND:Stem cells	Safety	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001786-36/GB">2020-001786-36</a>	Recombinant InterLeukin-7 (CYT107) to Improve clinical outcomes in lymphopenic pAtients with COVID-19 infection &ldquo;ILIAD 7 trial&rdquo;	France	Y	N	Drug Repurposing	CYT107	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-002312-43/ES">2020-002312-43</a>	Clinical trial, PHASE III, randomized, open-label, to evaluate the efficacy of administering high-dose cholecalciferol orally alongside standard therapy in patients with COVID-19 pneumonia (COVID-19 HUSO).	Spain	Y	N	Drug Repurposing	Vitamin D3	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001972-13/IT">2020-001972-13</a>	Randomised controlled trial comparing efficacy and safety of high versus low low-molecular weight heparin dosages in hospitalised patients with severe COVID-19 pneumonia and coagulopathy not requiring invasive mechanical ventilation (COVID-19 HD)	Italy	Y	N	Drug Repurposing	Enoxaparin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001498-63/BE">2020-001498-63</a>	Adaptive design phase 2 to 3, randomized, double- blind, multicenter, to evaluate the safety, efficacy, pharmacokinetics and pharmacodynamics of BIO101 in the prevention of the respiratory deterioration in hospitalized patients with COVID-19 pneumonia (severe stage)	France	Y	N	Shelved drug or NME	BIO101	Efficacy - Other efficacy	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001860-27/GB">2020-001860-27</a>	AGILE: Seamless Phase I/IIa Platform for the Rapid Evaluation of Candidates for COVID-19 treatment	United Kingdom	Y	N	Shelved drug or NME	Nomacopan	Safety	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001281-11/FR">2020-001281-11</a>	Evaluation of the concentration/viral effect relationship of hydroxychloroquine in COVID-19 patients in the intensive care unit.	France	N	N	Drug Repurposing	Hydroxychloroquine	Other	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001891-14/ES">2020-001891-14</a>	Impact of the use of low molecular weight heparins (LMWH), at prophylactic versus intermediate doses, on SARS-CoV2 infection (COVID-19)	Spain	Y	N	Drug Repurposing	Enoxaparin	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001598-66/FR">2020-001598-66</a>	Preliminary randomized controlled trial of poractant alfa (Curosurf&reg;) by fiberoptic bronchoscopy-directed endobronchial administration in acute respiratory distress syndrome (ARDS) due to COVID-19 viral pneumonia.	France	Y	N	Drug Repurposing	Poractant alfa	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001431-27/DE">2020-001431-27</a>	Treatment of Sars-CoV2 infections (COVID-19) with valsartan vs placebo, a three-armed randomized, partly blinded trial	Germany	Y	N	Drug Repurposing	Valsartan	Efficacy - WHO scale	Mild/Moderate Cases, Other	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001442-19/ES">2020-001442-19</a>	Pilot, randomized, multicenter, open-label clinical trial of combined use of hydroxychloroquine, azithromycin, and tocilizumab for the treatment of SARS-CoV-2 infection (COVID-19)	Spain	Y	N	Drug Repurposing	Tocilizumab	Efficacy - Mortality	Mild/Moderate Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001622-64/ES">2020-001622-64</a>	OUTPATIENT TREATMENT OF COVID-19 WITH EARLY PULMONARY CORTICOSTEROIDS AS AN OPPORTUNITY TO MODIFY THE COURSE OF THE DISEASE	Spain	Y	N	Drug Repurposing	Prednisone	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001827-15/ES">2020-001827-15</a>	EARLY TREATMENT OF PNEUMONIA COVID-19 WITH GLUCOCORTICOIDS.&#13; RANDOMIZED CONTROLLED CLINICAL TRIAL	Spain	Y	N	Drug Repurposing	Methylprednisolone	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001031-27/ES">2020-001031-27</a>	Treatment of non-severe confirmed cases of COVID-19 and chemoprophylaxis of their contacts as prevention strategy: a Cluster Randomized Clinical Trial (PEP CoV-2 Study)	Spain	Y	N	Drug Repurposing	Darunavir	Efficacy - Infection rate (prevention)	Mild/Moderate Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001754-21/FR">2020-001754-21</a>	An open prospective randomized therapeutic trial using ANAKINRA or TOCILIZUMAB alone or in combination with RUXOLITINIB in severe stage 2b and 3 COVID-19 disease	France	Y	N	Drug Repurposing	Anakinra, Tocilizumab, Ruxolitinib	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001113-21/GB">2020-001113-21</a>	Randomised Evaluation of COVID-19 Therapy (RECOVERY)	United Kingdom	Y	Y	Drug Repurposing	Lopinavir/ritonavir, Dexamethasone, Azithromycin, Tocilizumab	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001450-22/ES">2020-001450-22</a>	Phase II Clinical Trial to explore the efficacy of allogeneic mesenchymal cells from umbilical cord tissue in patients with severe pulmonary involvement by COVID-19.	Spain	Y	N	Cell/Blood based	ND:Stem cells	Efficacy - Mortality	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-000890-25/FR">2020-000890-25</a>	Treatment of Coronavirus SARS-Cov2 Respiratory Infections with Hydroxychloroquine	France	N	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001709-21/FR">2020-001709-21</a>	Effectiveness of low molecular weight heparin at increased doses prophylaxis weight-adjusted, compared with lower doses prophylaxis (intermediate or standard), on the onset of venous thromboembolism in coronavirus disease 2019 (COVID-19) hospitalized patients : The randomized multicentric controlled open-label trial COVI-DOSE	France	Y	N	Drug Repurposing	Enoxaparin, Tinzaparin, Nadroparin	Other	Mild/Moderate Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001255-40/ES">2020-001255-40</a>	Sarilumab Treatment In cytoKinE storm caused by infection with COVID-19.	Spain	N	N	Drug Repurposing	Sarilumab	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001722-66/ES">2020-001722-66</a>	Plasma turnover in patients with COVID-19 disease and invasive mechanical ventilation: a randomized study	Spain	Y	N	Drug Repurposing	Albumin	Efficacy - Mortality	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001614-38/BE">2020-001614-38</a>	Covid-19: A randomized, open-label, adaptive, proof-of- concept clinical trial of new antiviral drug candidates against SARS-CoV-2.	Belgium	Y	N	Drug Repurposing	Azithromycin	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001321-31/ES">2020-001321-31</a>	Prospective, phase II, randomized, open-label, parallel group study to evaluate the efficacy of hydroxychloroquine together with baricitinib, imatinib or early lopinavir / ritonavir in patients with SARS Cov2 pneumonia (COVID-19 HUF)	Spain	Y	Y	Drug Repurposing	Hydroxychloroquine, Baricitinib, Imatinib, Lopinavir/ritonavir	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001531-27/ES">2020-001531-27</a>	Clinical trial of Sarilumab in adults hospitalized with COVID-19 presenting cytokine release syndrome	Spain	Y	N	Drug Repurposing	Sarilumab	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001420-34/DK">2020-001420-34</a>	Senicapoc in COVID-19 Patients with Severe Respiratory Insufficiency &ndash; A Randomized, Open-Label, Phase II Trial	Denmark	Y	N	Shelved drug or NME	Senicapoc	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001246-18/FR">2020-001246-18</a>	Cohort Multiple randomized controlled trials open-label of immune modulatory drugs and other treatments in COVID-19 patients	France	Y	N	Drug Repurposing	Sarilumab, Tocilizumab, Nivolumab, Bevacizumab, Tinzaparin, Hydroxychloroquine, Eculizumab, Baricitinib, Secukinumab	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001244-26/AT">2020-001244-26</a>	COVID-19: Efficacy of solnatide to treat pulmonary permeability oedema in SARS-Cov-2 positive patients with moderate-to-severe ARDS - a pilot-trial.	Austria	Y	N	Shelved drug or NME	Solnatide	Efficacy - Other efficacy	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001390-76/IT">2020-001390-76</a>	A phase 3, randomized, open-labeled, multi-center study comparing clinical efficacy and safety of intravenous sarilumab plus standard of care compared to standard of care, in the treatment of patients with severe COVID-19 pneumonia	Italy	Y	N	Drug Repurposing	Sarilumab	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001310-38/DE">2020-001310-38</a>	A randomized, prospective, open label clinical trial on the use of convalescent plasma compared to best supportive care in patients with severe COVID-19	Germany	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-002713-17/ES">2020-002713-17</a>	A PHASE II, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, MULTICENTER STUDY TO EVALUATE THE SAFETY AND EFFICACY OF&#13; MSTT1041A OR UTTR1147A IN PATIENTS WITH SEVERE COVID-19 PNEUMONIA	Spain	Y	Y	Shelved drug or NME	MSTT1041A, UTTR1147A	Efficacy - WHO scale	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001409-21/ES">2020-001409-21</a>	A prospective, multicenter, randomized, parallel, double-blind, placebo-controlled phase IIb clinical trial to evaluate intravenous infusion of Defibrotide in the prevention and treatment of respiratory distress and cytokine release syndrome in patients with COVID-19.	Spain	Y	N	Drug Repurposing	Defibrotide	Efficacy - Mortality	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001732-10/DE">2020-001732-10</a>	Ruxolitinib for treatment of Covid-19 induced lung injury ARDS (RuXoCoil) A single-arm, open-label, proof of concept study	Germany	N	N	Drug Repurposing	Ruxolitinib	Efficacy - Mortality	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001632-10/DE">2020-001632-10</a>	A Randomized Open label Phase-II Clinical Trial with or without Infusion of Plasma from Subjects after Convalescence of SARS-CoV-2 Infection in High-Risk Patients with Confirmed Severe SARS-CoV-2 Disease	Germany	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - WHO scale	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-002193-27/ES">2020-002193-27</a>	Double-blind, randomized, controlled, clinical trial to assess the efficacy of allogenic mesenchymal stromal cells in patients with acute respiratory distress syndrome due to COVID-19	Spain	Y	N	Cell/Blood based	ND:Stem cells	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001156-18/ES">2020-001156-18</a>	Randomized clinical trial to evaluate the efficacy of different treatments in patients with COVID-19 who require hospitalization	Spain	Y	Y	Drug Repurposing	Lopinavir/ritonavir, Hydroxychloroquine, Azithromycin	Efficacy - Mortality	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2019-002688-89/ES">2019-002688-89</a>	Phase 1/2 clinical study to assess the feasibility, safety, tolerability and preliminary efficacy of the administration of HCR040, a drug whose active substance is HC016, allogeneic adipose-derived adult mesenchymal stem cells expanded and pulsed with H2O2, in patients with acute respiratory distress syndrome. (included patients COVID-19)	Spain	Y	N	Cell/Blood based	ND:Stem cells	Safety	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001768-27/FR">2020-001768-27</a>	"STUDY OF THE EFFICIENCY OF NORMAL HUMAN IMMUNOGLOBULINS (IVIG) IN PATIENTS AGED 75 YEARS AND OVER COVID-19 WITH SEVERE ACUTE RESPIRATORY FAILURE" GERONIMO 19	France	N	N	Cell/Blood based	Immunoglobulin	Efficacy - Mortality	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001319-26/ES">2020-001319-26</a>	Multicenter, randomized, controlled, open-label clinical trial to assess the prognostic implications of rosuvastatin treatment in patients discharged after hospitalization for COVID-19 Positive.	Spain	Y	N	Drug Repurposing	Rosuvastatin	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001379-34/ES">2020-001379-34</a>	Sedation with sevoflurane versus propofol in patients with Acute Respiratory Distress Syndrome caused by COVID-19 infection	Spain	Y	N	Drug Repurposing	Sevoflurane	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001257-51/DK">2020-001257-51</a>	The Danish Pre-HCQ Dialysis Study:&#13; Hydroxychloroquine for prevention of COVID-19 in dialysis-treated patients with end-stage renal disease -&#13; A multicenter parallel-group open randomized clinical trial&#13;	Denmark	Y	N	Drug Repurposing	Hydroxychloroquine	Other	Other	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001971-33/ES">2020-001971-33</a>	Pragmatic study "CORIVER": Ivermectin as antiviral treatment for patients infected by SARS-COV2 (COVID-19)	Spain	Y	N	Drug Repurposing	Ivermectin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001266-11/ES">2020-001266-11</a>	Two-center, randomized, controlled clinical trial with two treatment arms to evaluate the safety and efficacy of intravenous administration of expanded allogeneic adipose tissue adult mesenchymal cells in critically ill patients COVID-19.	Spain	Y	N	Cell/Blood based	ND:MSC	Efficacy - Mortality	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001717-20/ES">2020-001717-20</a>	Prevention and treatment with Calcifediol of Coronavirus COVID-19-induced acute respiratory syndrome (SARS)	Spain	Y	N	Drug Repurposing	Calcifediol	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001573-78/FR">2020-001573-78</a>	Recombinant InterLeukin-7 (CYT107) to Improve clinical outcomes in lymphopenic pAtients with COVID-19 infection	United States	Y	N	Shelved drug or NME	CYT-107	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001303-16/FR">2020-001303-16</a>	Efficacy of Hydroxychloroquine, Telmisartan and Azithromycin on Survival in Elderly Hospitalized Patients with VIDOC-19 : A Randomized, Multi-Centre, Adaptive, Blinded Study	France	Y	Y	Drug Repurposing	Hydroxychloroquine, Telmisartan, Azithromycin	Efficacy - Mortality	Severe Cases, Other	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001511-25/ES">2020-001511-25</a>	Randomized open-blind controlled trial to study the benefit of Colchicine in Patients with COVID-19	Spain	Y	N	Drug Repurposing	Colchicine	Efficacy - WHO scale	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001406-27/FR">2020-001406-27</a>	Randomized open label trial assessing efficacy and safety of hydroxychloroquine plus azithromycin versus hydroxychloroquine for hospitalized patients with COVID-19	France	Y	N	Drug Repurposing	Azithromycin	Efficacy - WHO scale	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001903-17/ES">2020-001903-17</a>	A randomized clinical trial (IIIb) of eficacy of a single dose of Tocilizumab or a combination of Tocilizumab plus Vitamin D (single i.m. dose) for the treatment of the COVID-19 hyperimmune complication. Assessment of IL-6.	Spain	Y	Y	Drug Repurposing	Tocilizumab, Vitamin D3	Efficacy - Mortality	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001265-36/IE">2020-001265-36</a>	A multicentre, prospective, randomised trial comparing standard of care (SOC) alone, SOC plus hydroxychloroquine monotherapy or SOC plus a combination of hydroxychloroquine and azithromycin in the treatment of non-critical, SARS-CoV-2 PCR-positive population not requiring immediate resuscitation or ventilation but who have evidence of clinical decline.	Ireland	Y	Y	Drug Repurposing	Azithromycin, Hydroxychloroquine	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001038-36/DE">2020-001038-36</a>	A Multi-site Phase I/II, 2-Part, Dose-Escalation Trial Investigating the Safety and Immunogenicity of four Prophylactic SARS-CoV-2 RNA Vaccines Against COVID-19 Using Different Dosing Regimens in Healthy Adults	Germany	N	N	Vaccine	BNT162 vaccine	Safety	General population	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-002037-15/ES">2020-002037-15</a>	Multicenter, randomized, open-label study to evaluate the efficacy and safety of SOC + Sarilumab versus Standard of Care for the Early Treatment of COVID-19-pneumonia in Hospitalized Patients	Spain	Y	N	Drug Repurposing	Sarilumab	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-002952-18/GB">2020-002952-18</a>	Targeting de novo Pyrimidine Biosynthesis by leflunomide as a Novel Concept for the Treatment of Corona Virus Disease 2019 (COVID-19)	United Kingdom	Y	N	Drug Repurposing	Leflunomide	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001739-28/BE">2020-001739-28</a>	A randomized, open-label, adaptive, proof-of-concept clinical trial of modulation of host thromboinflammatory response in patients with COVID-19.&#13; &#13;	Belgium	Y	N	Drug Repurposing	Aprotinin, Anakinra	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001307-16/ES">2020-001307-16</a>	Efficacy and Safety of corticoids in patients with adult respiratory distress syndrome (ARDS) secondary to COVID-19.	Spain	Y	N	Drug Repurposing	Methylprednisolone	Efficacy - Mortality	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001736-95/GB">2020-001736-95</a>	ACCORD 2: A Multicentre, Seamless, Phase 2 Adaptive Randomisation Platform Study to Assess the Efficacy and Safety of Multiple Candidate Agents for the Treatment of COVID 19 in Hospitalised Patients	United Kingdom	Y	N	Drug Repurposing, Shelved drug or NME	Bemcentinib, MEDI3506, Acalabrutinib, Zilucoplan	Efficacy - WHO scale	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001262-11/ES">2020-001262-11</a>	Randomized, controlled, blinded clinical trial for the evaluator, to evaluate the efficacy and safety of treatment with cyclosporine A (CsA) associated with standard treatment versus standard treatment only in hospitalized patients with confirmed infection by COVID-19	Spain	Y	N	Drug Repurposing	Cyclosporine	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001505-22/ES">2020-001505-22</a>	Double-blind, randomized, parallel, placebo-controlled pilot clinical trial, nested in a prospective cohort observational study, for the evaluation of the efficacy and safetyof two doses of WJ-MSC in patients with acute respiratory distress syndrome secondary to infection by COVID-19	Spain	Y	N	Cell/Blood based	ND:Stem cells	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001290-74/ES">2020-001290-74</a>	Efficacy and safety of sarilumab in the early treament of hospitalized patients with mild-moderate neumonia and COVID19 infection versus standard of care	Spain	Y	N	Drug Repurposing	Sarilumab	Efficacy - WHO scale	Mild/Moderate Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001413-20/ES">2020-001413-20</a>	Phase 2, randomized, open-label study to compare the efficacy and safety of siltuximab vs. corticosteroids in hospitalized patients with COVID19 pneumonia	Spain	Y	N	Drug Repurposing	Siltuximab, Methylprednisolone	Efficacy - Other efficacy	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001707-16/ES">2020-001707-16</a>	PHASE III RANDOMIZED, UNICENTRIC, OPEN, CONTROLLED CLINICAL TRIAL TO DEMONSTRATE THE EFFECTIVENESS OF TOCILIZUMAB AGAINST SYSTEMIC CORTICOTHERAPY IN PATIENTS ENTERED BY COVID-19 WITH BILATERAL PNEUMONIA AND BAD EVOLUTION	Spain	Y	N	Drug Repurposing	Tocilizumab	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-002632-75/GB">2020-002632-75</a>	Multicenter, open-label, randomised trial to assess the efficacy and tolerability of poractant alfa (porcine surfactant, Curosurf&reg;) in hospitalized patients with SARS-COV-19 acute respiratory distress syndrome (ARDS)	United States	Y	N	Drug Repurposing	Poractant alfa	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001405-23/ES">2020-001405-23</a>	Randomized phase II clinical trial of ruxolitinib plus simvastatin in the prevention and treatment of respiratory failure of COVID-19.Ruxo-Sim-20 clinical trial.	Spain	Y	N	Drug Repurposing	Ruxolitinib, Simvastatin	Efficacy - WHO scale	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04372602">NCT04372602</a>	Duvelisib to Combat COVID-19	United States	N	N	Drug Repurposing	Duvelisib	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04482621">NCT04482621</a>	Decitabine for Coronavirus (COVID-19) Pneumonia- Acute Respiratory Distress Syndrome (ARDS) Treatment: DART Trial	United States	Y	N	Drug Repurposing	Decitabine	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04425538">NCT04425538</a>	A Phase 2 Trial of Infliximab in Coronavirus Disease 2019 (COVID-19).	United States	N	N	Drug Repurposing	Infliximab	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04454307">NCT04454307</a>	Safety and Efficacy of Tramadol in COVID-19 Egyptian Patients	Egypt	Y	N	Drug Repurposing	Tramadol	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04333550">NCT04333550</a>	Application of Desferal to Treat COVID-19	Iran	Y	N	Drug Repurposing	Deferoxamine	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04432987">NCT04432987</a>	Dornase Alpha for the Treatment of COVID-19	Turkey	Y	N	Drug Repurposing	Dornase alfa	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04336904">NCT04336904</a>	Clinical Study To Evaluate The Performance And Safety Of Favipiravir in COVID-19	Italy	Y	N	Drug Repurposing	Favipiravir	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04359095">NCT04359095</a>	Effectiveness and Safety of Medical Treatment for SARS-CoV-2 (COVID-19) in Colombia	Colombia	Y	Y	Drug Repurposing	Hydroxychloroquine, Lopinavir/ritonavir, Azithromycin	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04354831">NCT04354831</a>	A Study Evaluating the Efficacy and Safety of High-Titer Anti-SARS-CoV-2 Plasma in Hospitalized Patients With COVID-19 Infection	United States	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04445285">NCT04445285</a>	Phase 2 Trial Using rhDNase to Reduce Mortality in COVID-19 Patients With Respiratory Failure	United States	Y	N	Drug Repurposing	Dornase alfa	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04345445">NCT04345445</a>	Study to Evaluate the Efficacy and Safety of Tocilizumab Versus Corticosteroids in Hospitalised COVID-19 Patients With High Risk of Progression	Malaysia	Y	N	Drug Repurposing	Tocilizumab, Methylprednisolone	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04476888">NCT04476888</a>	Convalescent Plasma Treatment in COVID-19	Pakistan	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04366739">NCT04366739</a>	Repurposing of Chlorpromazine in Covid-19 Treatment	France	Y	N	Drug Repurposing	Chlorpromazine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04366960">NCT04366960</a>	Comparison of Two Doses of Enoxaparin for Thromboprophylaxis in Hospitalized COVID-19 Patients	Italy	Y	Y	Drug Repurposing	Enoxaparin	Efficacy - Infection rate (prevention)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04361422">NCT04361422</a>	Isotretinoin in Treatment of COVID-19	Egypt	Y	N	Drug Repurposing	Isotretinoin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04405310">NCT04405310</a>	Convalescent Plasma of Covid-19 to Treat SARS-COV-2 a Randomized Doble Blind 2 Center Trial	Mexico	Y	Y	Cell/Blood based	ND:Convalescent plasma	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04328272">NCT04328272</a>	Effectiveness of Hydroxychloroquine in Covid-19 Patients	Pakistan	Y	N	Drug Repurposing	Hydroxychloroquine, Azithromycin	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04345679">NCT04345679</a>	Anti COVID-19 Convalescent Plasma Therapy	Hungary	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Viral load	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04461340">NCT04461340</a>	Efficacy and Safety of Sirolimus in COVID-19 Infection	Egypt	Y	N	Drug Repurposing	Sirolimus	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04428801">NCT04428801</a>	Autologous Adipose-derived Stem Cells (AdMSCs) for COVID-19	United States	Y	N	Cell/Blood based	ND:Stem cells	Safety	Other	
<a href="https://ClinicalTrials.gov/show/NCT04321421">NCT04321421</a>	Hyperimmune Plasma for Critical Patients With COVID-19	Italy	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04370288">NCT04370288</a>	Clinical Application of Methylene Blue for Treatment of Covid-19 Patients	Iran	Y	N	Drug Repurposing	Methylene blue, Ascorbic acid, N-acetylcysteine	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04347915">NCT04347915</a>	The Phase 2 Study to Evaluate the Safety and Efficacy of Clevudine in Patients With Moderate COVID-19	Korea, Republic of	Y	N	Drug Repurposing	Clevudine	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04333407">NCT04333407</a>	Preventing Cardiac Complication of COVID-19 Disease With Early Acute Coronary Syndrome Therapy: A Randomised Controlled Trial.	United Kingdom	Y	Y	Drug Repurposing	Aspirin, Clopidogrel, Rivaroxaban, Atorvastatin, Omeprazole	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04473690">NCT04473690</a>	KBP-201 COVID-19 Vaccine Trial in Healthy Volunteers	United States	Y	N	Vaccine	KBP-201 Vaccine	Safety	General population	
<a href="https://ClinicalTrials.gov/show/NCT04470622">NCT04470622</a>	Aprepitant Injectable Emulsion in Patients With COVID-19 (GUARDS-1)	United States	Y	N	Drug Repurposing	Aprepitant	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04401423">NCT04401423</a>	TXA COVID-19 Clinical Trial	United States	Y	N	Shelved drug or NME	TXA127	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04412486">NCT04412486</a>	COVID-19 Convalescent Plasma (CCP) Transfusion	United States	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04452669">NCT04452669</a>	VentaProst in Subjects With COVID-19 Requiring Mechanical Ventilation	United States	N	N	Drug Repurposing	Epoprostenol	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04406389">NCT04406389</a>	Anticoagulation in Critically Ill Patients With COVID-19 (The IMPACT Trial)	United States	Y	Y	Drug Repurposing	Enoxaparin, Heparin, Fondaparinux, Argatroban	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04463472">NCT04463472</a>	Study of COVID-19 DNA Vaccine (AG0301-COVID19)	Japan	N	N	Vaccine	AG0301 Vaccine	Safety	General population	
<a href="https://ClinicalTrials.gov/show/NCT04474483">NCT04474483</a>	Safety and Efficacy of Melatonin in Outpatients Infected With COVID-19	United States	Y	N	Drug Repurposing	Melatonin	Safety	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04393038">NCT04393038</a>	ABX464 in Treating Inflammation and Preventing Acute Respiratory Failure in Patients With COVID-19	France	Y	N	Shelved drug or NME	ABX464	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04434248">NCT04434248</a>	An Adaptive Study of Favipiravir Compared to Standard of Care in Hospitalized Patients With COVID-19	Russian Federation	Y	N	Drug Repurposing	Favipiravir	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04466657">NCT04466657</a>	Antioxidant Therapy for COVID-19 Study	Nigeria	Y	N	Drug Repurposing, Other	ND:Antioxidant supplements, N-acetylcysteine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04363346">NCT04363346</a>	Study of FT516 for the Treatment of COVID-19 in Hospitalized Patients With Hypoxia	United States	N	N	Shelved drug or NME	FT516	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04372979">NCT04372979</a>	Efficacy of Convalescent Plasma Therapy in the Early Care of COVID-19 Patients.	France	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04456413">NCT04456413</a>	Convalescent Plasma as Treatment for Subjects With Early COVID-19 Infection	United States	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04333420">NCT04333420</a>	Open-label, Randomized Study of IFX-1 in Patients With Severe COVID-19 Pneumonia	Netherlands	Y	N	Shelved drug or NME	IFX-1	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04467151">NCT04467151</a>	Administration of Anti-SARS-CoV-2 Convalescent Plasma in Hospitalized, Non-ICU Patients With COVID-19	United States	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04479358">NCT04479358</a>	Low-dose Tocilizumab Versus Standard of Care in Hospitalized Patients With COVID-19	United States	Y	N	Drug Repurposing	Tocilizumab	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04343755">NCT04343755</a>	Convalescent Plasma as Treatment for Hospitalized Subjects With COVID-19 Infection	United States	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04464395">NCT04464395</a>	Study of CPI-006 as Immunotherapy for Hospitalized COVID-19 Patients	United States	N	N	Shelved drug or NME	CPI-006	Safety	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04324489">NCT04324489</a>	DAS181 for Severe COVID-19: Compassionate Use	China	N	N	Shelved drug or NME	DAS181	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04432298">NCT04432298</a>	Study of the Efficacy and Safety of Intravenous Pamrevlumab, in Hospitalized Patients With Acute COVID-19 Disease	United States	Y	N	Shelved drug or NME	Pamrevlumab	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04449965">NCT04449965</a>	Povidone-Iodine Rinses in the Management of COVID-19	Canada	Y	N	Shelved drug or NME	Povidone-iodine	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04392141">NCT04392141</a>	Colchicine Plus Phenolic Monoterpenes to Treat COVID-19	Iran	Y	N	Drug Repurposing, Other	Colchicine, ND:Dietary supplement	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04370262">NCT04370262</a>	Multi-site Adaptive Trials for COVID-19	United States	Y	N	Drug Repurposing	Famotidine	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04382586">NCT04382586</a>	Covid-19 Infection and Pulmonary Distress Treatment With Zanubrutinib in Hospitalized Participants	United States	Y	N	Drug Repurposing	Zanubrutinib	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04459286">NCT04459286</a>	The Nitazoxanide Plus Atazanavir for COVID-19 Study	Nigeria	Y	N	Drug Repurposing	Nitazoxanide, Atazanavir/ritonavir	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04329611">NCT04329611</a>	ALBERTA HOPE COVID-19 for the Prevention of Severe COVID19 Disease	Canada	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04335123">NCT04335123</a>	Study of Open Label Losartan in COVID-19	United States	N	N	Drug Repurposing	Losartan	Safety	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04321993">NCT04321993</a>	Treatment of Moderate to Severe Coronavirus Disease (COVID-19) in Hospitalized Patients	Canada	Y	Y	Drug Repurposing	Baricitinib	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04376788">NCT04376788</a>	Exchange Transfusion Versus Plasma From Convalescent Patients With Methylene Blue in Patients With COVID-19	Egypt	Y	Y	Drug Repurposing, Cell/Blood based	Methylene blue, ND:Convalescent plasma	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04360356">NCT04360356</a>	Ivermectin and Nitazoxanide Combination Therapy for COVID-19	Egypt	Y	N	Drug Repurposing	Ivermectin, Nitazoxanide	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04350593">NCT04350593</a>	Dapagliflozin in Respiratory Failure in Patients With COVID-19	United States	Y	N	Drug Repurposing	Dapagliflozin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04361318">NCT04361318</a>	Hydroxychloroquine and Nitazoxanide Combination Therapy for COVID-19	Egypt	Y	N	Drug Repurposing	Hydroxychloroquine, Nitazoxanide	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04375046">NCT04375046</a>	Recombinant Bacterial ACE2 Receptors -Like Enzyme of B38-CAP Could be Promising COVID-19 Infection- and Lung Injury Preventing Drug Better Than Recombinant Human ACE2	Egypt	Y	N	Shelved drug or NME	rbACE2	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04420299">NCT04420299</a>	Clinical Trial on the Efficacy and Safety of Bemiparin in Patients Hospitalized Because of COVID-19	Spain	Y	N	Drug Repurposing	Bemiparin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04425629">NCT04425629</a>	Safety, Tolerability, and Efficacy of Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies for the Treatment of Ambulatory Adult Patients With COVID-19	United States	Y	N	Shelved drug or NME	REGN10987, REGN10933	Safety	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04352933">NCT04352933</a>	PROLIFIC ChemoprophylaxisTrial (COVID-19)	United Kingdom	Y	Y	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04364022">NCT04364022</a>	Efficacy of Pragmatic Same-day COVID-19 Ring Prophylaxis for Adult Individuals Exposed to SARS-CoV-2 in Switzerland	Switzerland	Y	Y	Drug Repurposing	Hydroxychloroquine, Lopinavir/ritonavir	Efficacy - Other efficacy	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04347889">NCT04347889</a>	Preventing COVID-19 in Healthcare Workers With HCQ: A RCT	United States	Y	N	Drug Repurposing	Hydroxychloroquine, Ascorbic acid	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04405102">NCT04405102</a>	COVID-19 Ozanimod Intervention Study	Canada	Y	N	Drug Repurposing	Ozanimod	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04358081">NCT04358081</a>	Hydroxychloroquine Monotherapy and in Combination With Azithromycin in Patients With Moderate and Severe COVID-19 Disease	United States	Y	Y	Drug Repurposing	Hydroxychloroquine, Azithromycin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04381052">NCT04381052</a>	Study for the Use of the IL-6 Inhibitor Clazakizumab in Patients With Life-threatening COVID-19 Infection	United States	N	N	Shelved drug or NME	Clazakizumab	Safety	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04325633">NCT04325633</a>	Efficacy of Addition of Naproxen in the Treatment of Critically Ill Patients Hospitalized for COVID-19 Infection	France	Y	N	Drug Repurposing	Naproxen	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04486001">NCT04486001</a>	Study of Intravenous Administration of Allogeneic Adipose Stem Cells for COVID-19	United States	N	N	Cell/Blood based	ND:Stem cells	Safety	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04464408">NCT04464408</a>	Favipiravir Therapy in Adults With Mild COVID-19	Saudi Arabia	Y	N	Drug Repurposing	Favipiravir	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04382066">NCT04382066</a>	Proof of Concept Study to Evaluate the Safety Profile of Plitidepsin in Patients With COVID-19	Spain	Y	Y	Shelved drug or NME	Plitidepsin	Safety	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04408456">NCT04408456</a>	Efficacy of Hydroxychloroquine (HCQ) as Post Exposure Prophylaxis (PEP) for Prevention of COVID-19	India	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04380532">NCT04380532</a>	Tableted COVID-19 Therapeutic Vaccine	Canada	N	N	Shelved drug or NME	ND:Convalescent plasma	Safety	General population	
<a href="https://ClinicalTrials.gov/show/NCT04432103">NCT04432103</a>	Treatment of Severe and Critical COVID-19 Pneumonia With Convalescent Plasma	Mexico	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04390178">NCT04390178</a>	Convalescent Plasma as Treatment for Acute Coronavirus Disease (COVID-19)	Sweden	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04415086">NCT04415086</a>	Treatment of Patients With COVID-19 With Convalescent Plasma	Brazil	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04485130">NCT04485130</a>	DISulfiram for COvid-19 (DISCO) Trial	United States	Y	N	Drug Repurposing	Disulfiram	Safety	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04385043">NCT04385043</a>	Hyperimmune Plasma in Patients With COVID-19 Severe Infection	Italy	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04317092">NCT04317092</a>	Tocilizumab in COVID-19 Pneumonia (TOCIVID-19)	Italy	N	N	Drug Repurposing	Tocilizumab	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04375202">NCT04375202</a>	Colchicine in COVID-19: a Pilot Study	Italy	Y	N	Drug Repurposing	Colchicine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04339660">NCT04339660</a>	Clinical Research of Human Mesenchymal Stem Cells in the Treatment of COVID-19 Pneumonia	China	Y	N	Shelved drug or NME	ND:Stem cells	Other	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04465695">NCT04465695</a>	Dual Therapy With Interferon Beta-1b and Clofazimine for COVID-19	Hong Kong	Y	Y	Drug Repurposing	Interferon beta-1b, Clofazimine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04348071">NCT04348071</a>	Safety and Efficacy of Ruxolitinib for COVID-19	United States	N	N	Drug Repurposing	Ruxolitinib	Safety	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04340232">NCT04340232</a>	Safety and Efficacy of Baricitinib for COVID-19	United States	N	N	Drug Repurposing	Baricitinib	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04329832">NCT04329832</a>	Hydroxychloroquine vs. Azithromycin for Hospitalized Patients With Suspected or Confirmed COVID-19	United States	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04388410">NCT04388410</a>	Safety and Efficacy of Convalescent Plasma Transfusion for Patients With COVID-19	Mexico	Y	N	Cell/Blood based	Convalescent plasma	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04489446">NCT04489446</a>	Sildenafil in COVID-19	Chile	Y	N	Drug Repurposing	Sildenafil	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04426695">NCT04426695</a>	Safety, Tolerability, and Efficacy of Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies for Hospitalized Adult Patients With COVID-19	United States	Y	N	Shelved drug or NME	REGN10987, REGN10933	Safety	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04467047">NCT04467047</a>	Safety and Feasibility of Allogenic MSC in the Treatment of COVID-19	Brazil	N	N	Cell/Blood based	ND:Stem cells	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04480632">NCT04480632</a>	Therapeutic Plasmapheresis in Critically Ill Adult Patients With COVID-19 Confirmed Diagnosis	Colombia	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04443270">NCT04443270</a>	Chloroquine Phosphate Prophylactic Use in Health Personnel Exposed to COVID-19 Patients	Mexico	N	N	Drug Repurposing	Chloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04324996">NCT04324996</a>	A Phase I/II Study of Universal Off-the-shelf NKG2D-ACE2 CAR-NK Cells for Therapy of COVID-19	China	N	Y	Cell/Blood based	ND:T-cells	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04384497">NCT04384497</a>	Convalescent Plasma for Treatment of COVID-19: An Exploratory Dose Identifying Study	Sweden	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04354597">NCT04354597</a>	Hydroxychloroquine and Azithromycin as Prophylaxis for Healthcare Workers Dealing With COVID19 Patients	Jordan	Y	N	Drug Repurposing	Hydroxychloroquine, Azithromycin	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04410354">NCT04410354</a>	Study of Merimepodib in Combination With Remdesivir in Adult Patients With Advanced COVID-19	United States	Y	N	Shelved drug or NME	Merimepodib	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04371406">NCT04371406</a>	Efficacy of Azithromycin-associated Hydroxychloroquine Therapy Given in General Practice in Early-stage Disease in COVID-19 Patients	France	Y	N	Drug Repurposing	Azithromycin, Hydroxychloroquine	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04380688">NCT04380688</a>	Acalabrutinib Study With Best Supportive Care Versus Best Supportive Care in Subjects Hospitalized With COVID-19.	United States	Y	N	Drug Repurposing	Acalabrutinib	Safety	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04449588">NCT04449588</a>	Efficacy and Safety Study of BDB-001 in Severe COVID-19 With ALI/ARDS	China	Y	N	Shelved drug or NME	BDB-001	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04346199">NCT04346199</a>	Acalabrutinib Study With Best Supportive Care Versus Best Supportive Care in Subjects Hospitalized With COVID-19.	United States	Y	N	Drug Repurposing	Acalabrutinib	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04359615">NCT04359615</a>	Favipiravir in Hospitalized COVID-19 Patients	Iran	Y	N	Drug Repurposing	Favipiravir	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04333355">NCT04333355</a>	Safety in Convalescent Plasma Transfusion to COVID-19	Mexico	N	N	Cell/Blood based	ND:Convalescent plasma	Safety	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04421404">NCT04421404</a>	Effects of COVID-19 Convalescent Plasma (CCP) on Coronavirus-associated Complications in Hospitalized Patients	United States	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04359316">NCT04359316</a>	Azithromycin in Hospitalized COVID-19 Patients	Iran	Y	N	Drug Repurposing	Azithromycin	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04381884">NCT04381884</a>	Ivermectin Effect on SARS-CoV-2 Replication in Patients With COVID-19	United States	Y	N	Drug Repurposing	Ivermectin	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04352400">NCT04352400</a>	Efficacy of Nafamostat in Covid-19 Patients (RACONA Study)	Italy	Y	N	Drug Repurposing	Nafamostat	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04364815">NCT04364815</a>	The University of the Philippines Hydroxychloroquine PEP Against COVID-19 Trial	Philippines	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04343768">NCT04343768</a>	An Investigation Into Beneficial Effects of Interferon Beta 1a, Compared to Interferon Beta 1b And The Base Therapeutic Regiment in Moderate to Severe COVID-19: A Randomized Clinical Trial	Iran	Y	Y	Drug Repurposing	Hydroxychloroquine, Lopinavir/ritonavir, Interferon Beta-1A, Interferon Beta-1B	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04365231">NCT04365231</a>	Hydroxychloroquine Azithromycin COVID-19 Pregnancy Trial	France	Y	N	Drug Repurposing	Hydroxychloroquine, Azithromycin	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04428008">NCT04428008</a>	Thymosin Alpha 1 to Prevent COVID-19 Infection in Elderly Renal Dialysis Patients	United States	Y	N	Drug Repurposing	Thymalfasin	Efficacy - Infection rate (prevention)	Other	
<a href="https://ClinicalTrials.gov/show/NCT04355936">NCT04355936</a>	Telmisartan for Treatment of COVID-19 Patients	Argentina	Y	N	Drug Repurposing	Telmisartan	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04252118">NCT04252118</a>	Mesenchymal Stem Cell Treatment for Pneumonia Patients Infected With COVID-19	China	Y	N	Shelved drug or NME	ND:Stem cells	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04466670">NCT04466670</a>	Hemostasis in COVID-19: an Adaptive Clinical Trial	Brazil	Y	Y	Drug Repurposing	Heparin, Aspirin, Enoxaparin	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04492475">NCT04492475</a>	Adaptive COVID-19 Treatment Trial 3 (ACTT-3)	United States	Y	N	Drug Repurposing, Shelved drug or NME	Interferon beta-1a	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04438980">NCT04438980</a>	Glucocorticoids in COVID-19 (CORTIVID)	Spain	Y	N	Drug Repurposing	Methylprednisolone	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04280705">NCT04280705</a>	Adaptive COVID-19 Treatment Trial (ACTT)	United States	Y	N	Shelved drug or NME	Remdesivir	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04401579">NCT04401579</a>	Adaptive COVID-19 Treatment Trial 2 (ACTT-2)	United States	Y	N	Drug Repurposing	Baricitinib	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04348656">NCT04348656</a>	CONvalescent Plasma for Hospitalized Adults With COVID-19 Respiratory Illness (CONCOR-1)	Canada	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04475107">NCT04475107</a>	The Efficacy and Safety of Pyramax in Mild to Moderate COVID-19 Patients	Korea, Republic of	Y	N	Drug Repurposing	Pyronaridine/Artesunate	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04343976">NCT04343976</a>	Pegylated Interferon Lambda Treatment for COVID-19	United States	Y	N	Shelved drug or NME	Peg-Interferon lambda	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04357808">NCT04357808</a>	Efficacy of Subcutaneous Sarilumab in Hospitalised Patients With Moderate-severe COVID-19 Infection (SARCOVID)	Spain	Y	N	Drug Repurposing	Sarilumab	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04441385">NCT04441385</a>	Study to Evaluate the Efficacy and Safety of Maraviroc in SARS-CoV-2 Infection (COVID-19).	Spain	Y	N	Drug Repurposing	Maraviroc	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04397328">NCT04397328</a>	COVID-19 PEP- High-risk Individuals in Long-term and Specialized Care - Canada	Canada	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04330586">NCT04330586</a>	A Trial of Ciclesonide in Adults With Mild COVID-19	Korea, Republic of	Y	Y	Drug Repurposing	Ciclesonide, Hydroxychloroquine	Efficacy - Viral load	General population	
<a href="https://ClinicalTrials.gov/show/NCT04414098">NCT04414098</a>	Ruxolitinib in the Treatment of Covid-19	Argentina	N	N	Drug Repurposing	Ruxolitinib	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04345523">NCT04345523</a>	Convalescent Plasma Therapy vs. SOC for the Treatment of COVID19 in Hospitalized Patients	Spain	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - WHO scale	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04374279">NCT04374279</a>	Trial to Promote Recovery From COVID-19 With Endocrine Therapy	United States	Y	N	Drug Repurposing	Bicalutamide	Efficacy - WHO scale	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04349592">NCT04349592</a>	Hydroxychloroquine With or Without Azithromycin for Virologic Cure of COVID-19	Qatar	Y	N	Drug Repurposing	Hydoxychloroquine, Azithromycin	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04350671">NCT04350671</a>	Interferon Beta 1a in Hospitalized COVID-19 Patients	Iran	Y	N	Drug Repurposing	Interferon beta-1A	Efficacy - WHO scale	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04425252">NCT04425252</a>	Safety and Anti-coronavirus Response of Suppression of Host Nucleotide Synthesis in Patients With COVID-19	United States	Y	N	Drug Repurposing	Brequinar	Safety	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04365257">NCT04365257</a>	Prazosin to Prevent COVID-19 (PREVENT-COVID Trial)	United States	Y	N	Drug Repurposing	Prazosin	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04379479">NCT04379479</a>	Clinical Effect of Dialyzable Leukocyte Extract in Suspected or Confirmed Cases of COVID-19 (FUTURE-T)	Mexico	Y	N	Shelved drug or NME	Dialyzable Leukocyte Extract	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04466540">NCT04466540</a>	Randomized Placebo-controlled Trial of Hydroxychloroquine in Outpatient Cases With Coronavirus Disease 2019 (COVID-19)	Brazil	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04350684">NCT04350684</a>	Umifenovir in Hospitalized COVID-19 Patients	Iran	Y	N	Drug Repurposing	Umifenovir	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04328285">NCT04328285</a>	Chemoprophylaxis of SARS-CoV-2 Infection (COVID-19) in Exposed Healthcare Workers	France	Y	Y	Drug Repurposing	Hydroxychloroquine, Lopinavir/ritonavir	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04299724">NCT04299724</a>	Safety and Immunity of Covid-19 aAPC Vaccine	China	N	N	Vaccine	ND:Covid-19 aAPC vaccine	Safety	General population, Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04456153">NCT04456153</a>	Atovaquone for Treatment of COVID-19	United States	Y	N	Drug Repurposing	Atovaquone	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04416048">NCT04416048</a>	Effect of Anticoagulation Therapy on Clinical Outcomes in COVID-19	Germany	Y	N	Drug Repurposing	Rivaroxaban	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04315298">NCT04315298</a>	Evaluation of the Efficacy and Safety of Sarilumab in Hospitalized Patients With COVID-19	United States	Y	Y	Drug Repurposing	Sarilumab	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04389359">NCT04389359</a>	PROphylaxis for paTiEnts at Risk of COVID-19 infecTion	United Kingdom	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04418518">NCT04418518</a>	A Trial of CONvalescent Plasma for Hospitalized Adults With Acute COVID-19 Respiratory Illness	United States	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04366232">NCT04366232</a>	Efficacy of Intravenous Anakinra and Ruxolitinib During COVID-19 Inflammation (JAKINCOV)	France	Y	N	Drug Repurposing	Ruxolitinib, Anakinra	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04363372">NCT04363372</a>	A Study for Efficacy and Safety of Live Biotherapeutic MRx4DP0004 to Treat COVID-19	United Kingdom	Y	N	Shelved drug or NME	MRx-4DP0004	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04355897">NCT04355897</a>	CoVID-19 Plasma in Treatment of COVID-19 Patients	United States	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04377620">NCT04377620</a>	Assessment of Efficacy and Safety of Ruxolitinib in Participants With COVID-19-Associated ARDS Who Require Mechanical Ventilation (RUXCOVID-DEVENT)	United States	Y	N	Drug Repurposing	Ruxolitinib	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04475991">NCT04475991</a>	Safety and Efficacy of Maraviroc and/or Favipiravir vs Currently Used Therapy in Severe COVID-19 Adults	Mexico	Y	Y	Drug Repurposing	Maraviroc, Favipiravir	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04435184">NCT04435184</a>	Crizanlizumab for Treating COVID-19 Vasculopathy	United States	Y	N	Drug Repurposing	Crizanlizumab	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04377750">NCT04377750</a>	The Use of Tocilizumab in the Management of Patients Who Have Severe COVID-19 With Suspected Pulmonary Hyperinflammation	Israel	Y	N	Drug Repurposing	Tocilizumab	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04448119">NCT04448119</a>	Control of COVID-19 Outbreaks in Long Term Care	Canada	Y	N	Drug Repurposing	Favipiravir	Efficacy - Infection rate (prevention)	Other	
<a href="https://ClinicalTrials.gov/show/NCT04353180">NCT04353180</a>	Assessment the Activity Value of Isotretinoin (13- Cis-Retinoic Acid ) in the Treatment of COVID-19 (Randomized)	Egypt	Y	Y	Drug Repurposing	Retinoic acid	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04371965">NCT04371965</a>	Povidone Iodine Mouthwash, Gargle, and Nasal Spray to Reduce Naso- Pharyngeal Viral Load in Patients With COVID-19	France	Y	N	Shelved drug or NME	Povidone-Iodine	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04363866">NCT04363866</a>	A Pilot Study to Assess Hydroxychloroquine in Patients With SARS-CoV-2 (COVID-19)	United States	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04330638">NCT04330638</a>	Treatment of COVID-19 Patients With Anti-interleukin Drugs	Belgium	Y	Y	Drug Repurposing	Anakinra, Siltuximab, Tocilizumab	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04394442">NCT04394442</a>	Hydroxychloroquine in COVID-19 Patients	Saudi Arabia	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04485429">NCT04485429</a>	Efficacy Assessment of Methylprednisolone and Heparin in Patients With COVID-19 Pneumonia	Brazil	Y	Y	Drug Repurposing	Methylprednisolone, Heparin	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04382625">NCT04382625</a>	Hydroxychloroquine in SARS-CoV-2 (COVID-19) Pneumonia Trial	United States	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Oxygen parameters	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04353206">NCT04353206</a>	Convalescent Plasma in ICU Patients With COVID-19-induced Respiratory Failure	United States	N	N	Cell/Blood based	ND:Convalescent plasma	Other	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04488081">NCT04488081</a>	I-SPY COVID-19 TRIAL: An Adaptive Platform Trial for Critically Ill Patients	United States	Y	Y	Drug Repurposing	Cenicriviroc, Icatibant, Razuprotafib, Apremilast	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04473053">NCT04473053</a>	Rapid Experimental Medicine for COVID-19	United Kingdom	Y	Y	Drug Repurposing, Shelved drug or NME	TD139, Nafamostat	Safety	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04400890">NCT04400890</a>	Randomized Proof-of-Concept Trial to Evaluate the Safety and Explore the Effectiveness of Resveratrol for COVID-19	United States	Y	N	Drug Repurposing	Resveratrol	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04425837">NCT04425837</a>	Effectiveness and Safety of Convalescent Plasma in Patients With High-risk COVID-19	Colombia	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04452474">NCT04452474</a>	Study of the Efficacy and Safety of a Single Administration of Olokizumab vs. Placebo in Addition to Standard Treatment in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection (COVID-19).	United States	Y	N	Shelved drug or NME	Olokizumab	Efficacy - WHO scale	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04361214">NCT04361214</a>	Leflunomide in Mild COVID-19 Patients	United States	N	N	Drug Repurposing	Leflunomide	Safety	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04380519">NCT04380519</a>	Study of the Efficacy and Safety of a Single Administration of Olokizumab and RPH-104 With Standard Therapy in Patients With Severe Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection (COVID-19)	Russian Federation	Y	N	Shelved drug or NME	Olokizumab, RPH-104	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04483635">NCT04483635</a>	Preventing COVID-19 With High-dose Vitamin D Supplements	Canada	Y	N	Drug Repurposing	Vitamin D	Efficacy - Infection rate (prevention)	General population	
<a href="https://ClinicalTrials.gov/show/NCT04313322">NCT04313322</a>	Treatment of COVID-19 Patients Using Wharton's Jelly-Mesenchymal Stem Cells	Jordan	N	N	Cell/Blood based	ND:Stem cells	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04369742">NCT04369742</a>	Treating COVID-19 With Hydroxychloroquine (TEACH)	United States	Y	N	Drug Repurposing	Hydroxychloroquine	Safety	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04394117">NCT04394117</a>	Controlled evaLuation of Angiotensin Receptor Blockers for COVID-19 respIraTorY Disease	Australia	Y	N	Drug Repurposing	Angiotensin Receptor Blockers	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04389411">NCT04389411</a>	The COvid-19 Symptom MOntelukast Trial	Canada	Y	N	Drug Repurposing	Montelukast	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04398303">NCT04398303</a>	ACT-20 in Patients With Severe COVID-19 Pneumonia	United States	Y	Y	Cell/Blood based	ND:Stem cells	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04435795">NCT04435795</a>	Inhaled Ciclesonide for Outpatients With COVID19	United States	Y	N	Drug Repurposing	Ciclesonide	Efficacy - Oxygen parameters	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04425707">NCT04425707</a>	Ivermectin In Treatment of COVID 19 Patients	Egypt	Y	N	Drug Repurposing	Ivermectin	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04355767">NCT04355767</a>	Convalescent Plasma in Outpatients With COVID-19	United States	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04326920">NCT04326920</a>	Sargramostim in Patients With Acute Hypoxic Respiratory Failure Due to COVID-19 (SARPAC)	Belgium	Y	N	Drug Repurposing	Sargramostim	Efficacy - Oxygen parameters	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04446377">NCT04446377</a>	A Study of LAM-002A for the Prevention of Progression of COVID-19	United States	Y	N	Shelved drug or NME	Apilimod dimesylate	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04304313">NCT04304313</a>	A Pilot Study of Sildenafil in COVID-19	China	N	N	Drug Repurposing	Sildenafil	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04390503">NCT04390503</a>	Convalescent Plasma for COVID-19 Close Contacts	United States	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Other efficacy	Exposed individuals (family members, HCP), Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04382755">NCT04382755</a>	Zilucoplan  in Improving Oxygenation and Short- and Long-term Outcome of COVID-19 Patients With Acute Hypoxic Respiratory Failure	Belgium	Y	N	Shelved drug or NME	Zilucoplan	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04365699">NCT04365699</a>	Cardiovascular Effects of COVID-19	United States	N	N	Shelved drug or NME	AT-001	Efficacy - Other efficacy	Other	
<a href="https://ClinicalTrials.gov/show/NCT04458298">NCT04458298</a>	A Study to Evaluate OP-101 (Dendrimer N-acetyl-cysteine) in Severe Coronavirus Disease 2019 (COVID-19) Patients	United States	Y	N	Shelved drug or NME	OP-101	Safety	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04351243">NCT04351243</a>	A Study to Assess the Efficacy and Safety of Gimsilumab in Subjects With Lung Injury or Acute Respiratory Distress Syndrome Secondary to COVID-19 (BREATHE)	United States	Y	N	Shelved drug or NME	Gimsilumab	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04355247">NCT04355247</a>	Prophylactic Corticosteroid to Prevent COVID-19 Cytokine Storm	United States	N	N	Drug Repurposing	Methylprednisolone	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04405908">NCT04405908</a>	SCB-2019 as COVID-19 Vaccine	China	Y	Y	Vaccine	ND:Vaccine	Safety	General population	
<a href="https://ClinicalTrials.gov/show/NCT04353284">NCT04353284</a>	Camostat Mesylate in COVID-19 Outpatients	United States	Y	N	Drug Repurposing	Camostat	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04389710">NCT04389710</a>	Convalescent Plasma for the Treatment of COVID-19	United States	N	N	Cell/Blood based	ND:Convalescent plasma	Other	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04494399">NCT04494399</a>	IFN Beta-1b and Ribavirin for Covid-19	Hong Kong	Y	N	Drug Repurposing	Interferon beta-1b, Ribavirin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04380402">NCT04380402</a>	Atorvastatin as Adjunctive Therapy in COVID-19	United States	Y	N	Drug Repurposing	Atorvastatin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04374903">NCT04374903</a>	Hydroxychloroquine in Combination With Azithromycin or Sirolimus for Treating COVID-19 Patients	Jordan	Y	N	Drug Repurposing	Azithromycin, Sirolimus	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04386239">NCT04386239</a>	Study on the Use of Sarilumab in Patients With COVID-19 Infection	Italy	N	N	Drug Repurposing	Sarilumab	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04354805">NCT04354805</a>	Administration of Chlorpromazine as a Treatment for COVID-19	Egypt	Y	N	Drug Repurposing	Chlorpromazine	Other	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04351763">NCT04351763</a>	Amiodarone or Verapamil in COVID-19 Hospitalized Patients With Symptoms	Poland	Y	Y	Drug Repurposing	Amiodarone, Verapamil	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04388527">NCT04388527</a>	COVID-19 Convalescent Plasma for Mechanically Ventilated Population	United States	N	N	Cell/Blood based	ND:Convalescent plasma	Safety	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04340544">NCT04340544</a>	Hydroxychloroquine for the Treatment of Mild COVID-19 Disease	Germany	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04487444">NCT04487444</a>	Thymalfasin (Thymosin Alpha 1) to Treat COVID-19 Infection	United States	Y	N	Drug Repurposing	Thymalfasin	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04338828">NCT04338828</a>	Nitric Oxide Inhalation Therapy for COVID-19 Infections in the ED	United States	Y	N	Drug Repurposing	Nitric Oxide	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04480424">NCT04480424</a>	Study to Evaluate the Safety and Efficacy of High Dose Intravenous Immune Globulin (IVIG) Plus Standard Medical Treatment (SMT) Versus SMT Alone in Participants in Intensive Care Unit (ICU) With Coronavirus Disease (COVID-19)	United States	Y	N	Cell/Blood based	ND:Immunoglobulin	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04468087">NCT04468087</a>	Antiviral Agents Against COVID-19 Infection	Brazil	Y	Y	Drug Repurposing	Atazanavir, Daclatasvir, Sofusbuvir	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04338958">NCT04338958</a>	Ruxolitinib in Covid-19 Patients With Defined Hyperinflammation	Germany	N	N	Drug Repurposing	Ruxolitinib	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04356690">NCT04356690</a>	Etoposide in Patients With COVID-19 Infection	United States	N	N	Drug Repurposing	Etoposide	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04472494">NCT04472494</a>	Study of Abatacept in the Treatment of Hospitalized COVID-19 Participants With Respiratory Compromise	United States	Y	N	Drug Repurposing	Abatacept	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04415151">NCT04415151</a>	Tofacitinib for Treatment of Moderate COVID-19	United States	Y	N	Drug Repurposing	Tofacitinib	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04375124">NCT04375124</a>	Treatment of Angiotensin Peptide (1-7) for COVID-19	Turkey	N	N	Drug Repurposing	Angiotensin 1-7	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04371952">NCT04371952</a>	DYNAMIC Study (DoxycYcliNe AMbulatoIre COVID-19)	France	Y	N	Drug Repurposing	Doxycycline	Efficacy - Oxygen parameters	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04371822">NCT04371822</a>	Efficacy of Sunlight Activated Synthetic Porphyrin in COVID-19 Infected Patients	Egypt	Y	Y	Shelved drug or NME	SnPP Protoporphyrin, Sulfonatoporphyrin	Efficacy - Infection rate (prevention)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04427098">NCT04427098</a>	Enoxaparin in COVID-19 Moderate to Severe Hospitalized Patients	Iceland	N	N	Drug Repurposing	Enoxaparin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04438694">NCT04438694</a>	Use of Convalescent Plasma for Treatment of Patients With COVID-19 Infection	Egypt	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04443725">NCT04443725</a>	Efficacy and Safety of Anti HCV Drugs in the Treatment of COVID-19	Egypt	Y	N	Drug Repurposing	Hydroxychloroquine, Sofosbuvir, Daclatasvir	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04366115">NCT04366115</a>	Evaluating AVM0703 for Treatment of COVID-19	United States	Y	N	Drug Repurposing, Shelved drug or NME	AVM0703	Safety	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04383002">NCT04383002</a>	High Dose Inhaled Nitric Oxide for COVID-19 (ICU Patients)	Canada	Y	N	Drug Repurposing	Nitric Oxide	Efficacy - Viral load	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04410328">NCT04410328</a>	Aggrenox To Treat Acute Covid-19	United States	Y	N	Drug Repurposing	Aspirin/dipyridamole	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04445935">NCT04445935</a>	Anticoagulation in Patients Suffering From COVID-19 Disease The ANTI-CO Trial	Qatar	Y	N	Drug Repurposing	Bivalirudin	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04343092">NCT04343092</a>	Efficacy of Ivermectin as Add on Therapy in COVID19 Patients	Iraq	Y	N	Drug Repurposing	Ivermectin	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04338074">NCT04338074</a>	TXA and Corona Virus 2019 (COVID19) in Outpatients	United States	Y	N	Drug Repurposing	Tranexamic acid	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04494724">NCT04494724</a>	Clazakizumab vs. Placebo - COVID-19 Infection	United States	Y	N	Shelved drug or NME	Clazakizumab	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04366050">NCT04366050</a>	Ramipril for the Treatment of COVID-19	United States	Y	N	Drug Repurposing	Ramipril	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04438850">NCT04438850</a>	COVidIVERmectin: Ivermectin for Treatment of Covid-19	Italy	Y	N	Drug Repurposing	Ivermectin	Safety	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04338126">NCT04338126</a>	Tranexamic Acid (TXA) and Corona Virus 2019 (COVID19) in Inpatients	United States	Y	N	Drug Repurposing	Tranexamic acid	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04355026">NCT04355026</a>	Use of Bromhexine and Hydroxychloroquine for Treatment of COVID-19 Pneumonia	Slovenia	Y	N	Drug Repurposing	Bromhexine	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04341675">NCT04341675</a>	Sirolimus Treatment in Hospitalized Patients With COVID-19 Pneumonia	United States	Y	N	Drug Repurposing	Sirolimus	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04444271">NCT04444271</a>	Mesenchymal Stem Cell Infusion for COVID-19 Infection	Pakistan	Y	N	Cell/Blood based	ND:Stem cells	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04469114">NCT04469114</a>	Tofacitinib in Hospitalized Patients With COVID-19 Pneumonia	Brazil	Y	N	Drug Repurposing	Tofacitinib	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04446104">NCT04446104</a>	A Preventive Treatment for Migrant Workers at High-risk of Covid-19	Singapore	Y	Y	Drug Repurposing	Hydroxychloroquine, Ivermectin, Zinc, Povidone-Iodine	Efficacy - Oxygen parameters	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04329923">NCT04329923</a>	The PATCH Trial (Prevention And Treatment of COVID-19 With Hydroxychloroquine)	United States	Y	Y	Drug Repurposing	Hydroxychloroquine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04394416">NCT04394416</a>	Trial of Imatinib for Hospitalized Adults With COVID-19	United States	Y	N	Drug Repurposing	Imatinib	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04374461">NCT04374461</a>	A Study of N-acetylcysteine in Patients With COVID-19 Infection	United States	N	N	Drug Repurposing	N-acetylcysteine	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04397757">NCT04397757</a>	COVID-19 Convalescent Plasma for the Treatment of Hospitalized Patients With Pneumonia Caused by SARS-CoV-2.	United States	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04361643">NCT04361643</a>	Low-dose Lenalidomide for Non-severe COVID-19 Treatment Trial	Spain	Y	N	Drug Repurposing	Lenalidomide	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04455243">NCT04455243</a>	Inflammatory Regulation Effect of NAC on COVID-19 Treatment	Saudi Arabia	Y	N	Drug Repurposing	N-acetylcysteine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04333628">NCT04333628</a>	Chloroquine for Mild Symptomatic and Asymptomatic COVID-19	Israel	Y	Y	Drug Repurposing	Chloroquine	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04463602">NCT04463602</a>	Desidustat in the Management of COVID-19 Patients	Mexico	Y	N	Shelved drug or NME	Desidustat	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04372628">NCT04372628</a>	Trial of Early Therapies During Non-hospitalized Outpatient Window for COVID-19	United States	Y	N	Drug Repurposing	Lopinavir/ritonavir	Efficacy - WHO scale	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04429763">NCT04429763</a>	Safety and Efficacy of Mesenchymal Stem Cells in the Management of Severe COVID-19 Pneumonia	Colombia	Y	N	Cell/Blood based	ND:Stem cells	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04304053">NCT04304053</a>	Treatment of COVID-19 Cases and Chemoprophylaxis of Contacts as Prevention	Spain	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP), Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04421027">NCT04421027</a>	A Study of Baricitinib (LY3009104) in Participants With COVID-19	United States	Y	N	Drug Repurposing	Baricitinib	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04355143">NCT04355143</a>	Colchicine to Reduce Cardiac Injury in COVID-19 (COLHEART-19)	United States	Y	N	Drug Repurposing	Colchicine	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04451174">NCT04451174</a>	Early Use of Corticosteroids in Hospitalized Patients With Moderate COVID19 Pneumonia	Chile	Y	N	Drug Repurposing	Prednisone	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04362085">NCT04362085</a>	Coagulopathy of COVID-19: A Pragmatic Randomized Controlled Trial of Therapeutic Anticoagulation Versus Standard Care	Canada	Y	N	Drug Repurposing	Enoxaparin, Dalteparin, Tinzaparin, Heparin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04351620">NCT04351620</a>	High-dose Hydroxychloroquine for the Treatment of Ambulatory Patients With Mild COVID-19	United States	N	N	Drug Repurposing	Hydroxychloroquine	Safety	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04390464">NCT04390464</a>	mulTi-Arm Therapeutic Study in Pre-ICu Patients Admitted With Covid-19 - Repurposed Drugs (TACTIC-R)	United Kingdom	Y	Y	Drug Repurposing	Ravulizumab, Baricitinib	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04480138">NCT04480138</a>	Pegylated Interferon - a2b With SARSCoV- 2 (COVID-19)	Mexico	Y	N	Drug Repurposing	Interferon alpha-2b	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04363216">NCT04363216</a>	Pharmacologic Ascorbic Acid as an Activator of Lymphocyte Signaling for COVID-19 Treatment	United States	Y	N	Drug Repurposing	Ascorbic Acid	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04339426">NCT04339426</a>	Atovaquone and Azithromycin Combination for Confirmed COVID-19 Infection	United States	N	N	Drug Repurposing	Atovaquone, Azithromycin	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04334382">NCT04334382</a>	Hydroxychloroquine vs. Azithromycin for Outpatients in Utah With COVID-19	United States	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04437693">NCT04437693</a>	Post Exposure Prophylaxis in Healthcare Workers Exposed to COVID-19 Patients	Qatar	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04438057">NCT04438057</a>	Evaluating the Efficacy of Convalescent Plasma in Symptomatic Outpatients Infected With COVID-19	United States	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04350320">NCT04350320</a>	Trial to Study the Benefit of Colchicine in Patients With COVID-19	Spain	Y	N	Drug Repurposing	Colchicine	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04342182">NCT04342182</a>	Convalescent Plasma as Therapy for Covid-19 Severe SARS-CoV-2 Disease (CONCOVID Study)	Netherlands	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04343001">NCT04343001</a>	Coronavirus Response - Active Support for Hospitalised Covid-19 Patients	United Kingdom	Y	Y	Drug Repurposing	Aspirin, Losartan, Simvastatin	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04463420">NCT04463420</a>	Safety and Efficacy of PHR 160 Spray on the Outcomes of Patients With COVID-19	Iran	Y	N	Shelved drug or NME	PHR160 Spray	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04410159">NCT04410159</a>	Povidone-Iodine Vs Essential Oil Vs Tap Water Gargling For COVID-19 Patients	Malaysia	Y	Y	Shelved drug or NME	Povidone-Iodine	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04357990">NCT04357990</a>	Kerecis Oral and Nasal Spray for Treating the Symptoms of COVID-19	Iceland	Y	N	Shelved drug or NME	Omega3 Viruxide	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04356534">NCT04356534</a>	Convalescent Plasma Trial in COVID -19 Patients	Bahrain	Y	N	Cell/Blood based	ND:Covalescent plasma	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04393311">NCT04393311</a>	Ulinastatin for the Treatment of COVID-19 in Hospitalized Patients	United States	Y	N	Shelved drug or NME	Ulinastatin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04348500">NCT04348500</a>	Clazakizumab (Anti-IL- 6 Monoclonal) Compared to Placebo for COVID19 Disease	United States	Y	N	Shelved drug or NME	Clazakizumab	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04392414">NCT04392414</a>	Hyperimmune Convalescent Plasma in Moderate and Severe COVID-19 Disease	Russian Federation	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04442191">NCT04442191</a>	Convalescent Plasma as a Possible Treatment for COVID-19	United States	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Oxygen parameters	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04362189">NCT04362189</a>	Efficacy and Safety Study of Allogeneic HB-adMSCs for the Treatment of COVID-19	United States	Y	Y	Cell/Blood based	ND:Stem cells	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04409522">NCT04409522</a>	Evaluation of Therapeutic Effects of Melatonin by Inhibition of NLRP3 Inflammasome in COVID19 Patients	Iran	Y	N	Drug Repurposing	Melatonin	Other	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04360980">NCT04360980</a>	The Effects of Standard Protocol With or Without Colchicine in Covid-19 Infection	Iran	Y	N	Drug Repurposing	Colchicine	Other	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04335136">NCT04335136</a>	Recombinant Human Angiotensin-converting Enzyme 2 (rhACE2) as a Treatment for Patients With COVID-19	Denmark	Y	N	Shelved drug or NME	Recombinant Human Angiotensin-converting Enzyme 2	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04391127">NCT04391127</a>	Hydroxychloroquine and Ivermectin for the Treatment of COVID-19 Infection	Mexico	Y	N	Drug Repurposing	Ivermectin, Hydroxychloroquine	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04359537">NCT04359537</a>	Efficacy of Various Doses of Hydroxychloroquine in Pre-Exposure Prophylaxis for COVID 19	Pakistan	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04457726">NCT04457726</a>	Part Two of Novel Adoptive Cellular Therapy With SARS-CoV-2 Specific T Cells in Patients With Severe COVID-19	Singapore	N	N	Cell/Blood based	ND:T-cells	Safety	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04492254">NCT04492254</a>	Early Prophylactic Low-molecular-weight Heparin (LMWH) in Symptomatic COVID-19 Positive Patients	United Kingdom	Y	N	Drug Repurposing	Enoxaparin	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04276896">NCT04276896</a>	Immunity and Safety of Covid-19 Synthetic Minigene Vaccine	China	N	N	Cell/Blood based	ND:T-cells	Efficacy - WHO scale	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04370236">NCT04370236</a>	XPro1595 for the Treatment of Pulmonary Complications From COVID-19	United States	Y	N	Drug Repurposing	XPro1595	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04359511">NCT04359511</a>	Efficacy and Safety of Corticosteroids in Oxygen-dependent Patients With COVID-19 Pneumonia	France	Y	N	Drug Repurposing	Prednisone, Hydrocortisone	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04331795">NCT04331795</a>	Tocilizumab to Prevent Clinical Decompensation in Hospitalized, Non-critically Ill Patients With COVID-19 Pneumonitis	United States	N	Y	Drug Repurposing	Tocilizumab	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04456452">NCT04456452</a>	Study of Ampion for the Treatment of Adult COVID-19 Patients Requiring Oxygen Supplementation	United States	Y	N	Drug Repurposing	Ampion	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04333225">NCT04333225</a>	Hydroxychloroquine in the Prevention of COVID-19 Infection in Healthcare Workers	United States	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04405843">NCT04405843</a>	Efficacy of Ivermectin in Adult Patients With Early Stages of COVID-19	Colombia	Y	N	Drug Repurposing	Ivermectin	Efficacy - WHO scale	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04351724">NCT04351724</a>	Austrian CoronaVirus Adaptive Clinical Trial (COVID-19)	Austria	Y	Y	Drug Repurposing, Shelved drug or NME	Hydroxychloroquine, Chloroquine, Lopinavir/ritonavir, Rivaroxaban, Candesartan, Clazakizumab	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04393246">NCT04393246</a>	mulTi-Arm Therapeutic Study in Pre-ICu Patients Admitted With Covid-19 - Experimental Drugs and Mechanisms	United Kingdom	Y	N	Shelved drug or NME	EDP1815, Dapagliflozin, Ambrisentan	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04344444">NCT04344444</a>	Treatment in Patients With Suspected or Confirmed COVID-19 With Early Moderate or Severe Disease	United States	Y	Y	Drug Repurposing	Hydroxychloroquine, Azithromycin	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04429867">NCT04429867</a>	Hydroxychloroquine Use in Hospitalized Patients With COVID-19: Impact on Progression to Severe or Critical Disease	United States	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04377659">NCT04377659</a>	Tocilizumab for Prevention of Respiratory Failure in Patients With Severe COVID-19 Infection	United States	Y	N	Drug Repurposing	Tocilizumab	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04425772">NCT04425772</a>	A Clinical Trial for Azvudine in the Treatment of Novel Coronavirus Pneumonia (COVID-19)	United States	Y	N	Drug Repurposing	Azvudine	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04352465">NCT04352465</a>	Efficacy and Safety of MTX-loaded Nanoparticles to Treat Severe COVID-19 Patients	Brazil	N	N	Shelved drug or NME	Methotrexate nano-formulation	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04435314">NCT04435314</a>	Efficacy and Safety of Nitazoxanide for Post Exposure Prophylaxis of COVID-19	Brazil	Y	N	Drug Repurposing	Nitazoxanide	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04352751">NCT04352751</a>	Experimental Use of Convalescent Plasma for Passive Immunization in Current COVID-19 Pandemic in Pakistan in 2020	Pakistan	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04389801">NCT04389801</a>	Use of Desferal for Prevention of ARDS in Hospitalised Cases Documented With Covid 19 Infection	Egypt	Y	N	Drug Repurposing	Deferoxamine	Efficacy - Mortality	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04427501">NCT04427501</a>	A Study of LY3819253 (LY-CoV555) in Participants With Mild to Moderate COVID-19 Illness	United States	Y	N	Shelved drug or NME	LY3819253	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04486313">NCT04486313</a>	Trial to Evaluate Efficacy and Safety of Nitazoxanide in the Treatment of Mild or Moderate COVID-19	United States	Y	N	Drug Repurposing	Nitazoxanide, ND:Dietary supplement	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04374487">NCT04374487</a>	Assess the Safety and Efficacy of Convalescent Plasma to Limit COVID-19 Associated Complications	India	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04328441">NCT04328441</a>	Reducing Health Care Workers Absenteeism in Covid-19 Pandemic Through BCG Vaccine	Netherlands	Y	N	Drug Repurposing, Vaccine	BCG Vaccine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04432766">NCT04432766</a>	A Phase 1 Study to Assess BAT2020 in Hospitalized Patients Infected With SARS-CoV-2 (COVID-19)	China	Y	N	Shelved drug or NME	BAT2020	Safety	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04429711">NCT04429711</a>	Ivermectin vs. Placebo for the Treatment of Patients With Mild to Moderate COVID-19	Israel	Y	N	Drug Repurposing	Ivermectin	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04307693">NCT04307693</a>	Comparison of Lopinavir/Ritonavir or Hydroxychloroquine in Patients With Mild Coronavirus Disease (COVID-19)	Korea, Republic of	Y	Y	Drug Repurposing	Hydroxychloroquine, Lopinavir/ritonavir	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04329650">NCT04329650</a>	Efficacy and Safety of Siltuximab vs. Corticosteroids in Hospitalized Patients With COVID-19 Pneumonia	Spain	Y	N	Drug Repurposing	Siltuximab, Methylprednisolone	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04468139">NCT04468139</a>	The Study of Quadruple Therapy Zinc, Quercetin, Bromelain and Vitamin C on the Clinical Outcomes of Patients Infected With COVID-19	Saudi Arabia	N	N	Drug Repurposing, Other	Ascorbic acid, ND:Quercetin/bromelain, Zinc	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04385849">NCT04385849</a>	Study of the Safety of Therapeutic Treatment With an Immunomodulatory Agent (N-803) in Adults With COVID-19	United States	Y	N	Shelved drug or NME	N-803	Safety	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04454398">NCT04454398</a>	Study to Evaluate STI-1499 (COVI-GUARD) in Hospitalized Patients With COVID-19	United States	Y	N	Cell/Blood based	STI-1499	Safety	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04363814">NCT04363814</a>	Clinical Impact of BACTEK-R in Subject With Mild Pneumonia Due to COVID-19 Infection	United States	Y	N	Shelved drug or NME	Bactek-R	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04345692">NCT04345692</a>	A Randomized Controlled Clinical Trial: Hydroxychloroquine for the Treatment of COVID-19 in Hospitalized Patients	United States	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - WHO scale	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04364763">NCT04364763</a>	A Study to Evaluate the Effect of RBT-9 on Progression of COVID-19 in High-Risk Individuals (The PREVENT Study)	United States	N	N	Shelved drug or NME	RBT-9	Efficacy - WHO scale	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04397562">NCT04397562</a>	A Clinical Trial of the Efficacy and Safety of Levilimab (BCD-089) in Patients With Severe COVID-19	Russian Federation	Y	N	Shelved drug or NME	Levilimab	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04331899">NCT04331899</a>	Single-Blind Study of a Single Dose of Peginterferon Lambda-1a Compared With Placebo in Outpatients With Mild COVID-19	United States	Y	N	Shelved drug or NME	Peg-Interferon lambda-1a	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04397718">NCT04397718</a>	Hormonal Intervention for the Treatment in Veterans With COVID-19 Requiring Hospitalization	United States	Y	N	Drug Repurposing	Degarelix	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04362332">NCT04362332</a>	Chloroquine, Hydroxychloroquine or Only Supportive Care in Patients AdmItted With Moderate to Severe COVID-19	Netherlands	Y	Y	Drug Repurposing	Chloroquine, Hydroxychloroquine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04441398">NCT04441398</a>	Efficacy and Safety of Nitazoxanide 600 mg to Treat Mild Ambulatory COVID-19 Patients	Brazil	Y	N	Drug Repurposing	Nitazoxanide	Efficacy - WHO scale	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04486508">NCT04486508</a>	Intermediate-dose vs Standard Prophylactic Anticoagulation and Statin vs Placebo in ICU Patients With COVID-19	Iran	Y	Y	Drug Repurposing	Enoxaparin, Atorvastatin	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04434131">NCT04434131</a>	Treatment With Investigational Convalescent Plasma and Measure Antibody Levels in Patients Hospitalized With COVID-19	United States	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04331834">NCT04331834</a>	Pre-Exposure Prophylaxis With Hydroxychloroquine for High-Risk Healthcare Workers During the COVID-19 Pandemic	Spain	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04331470">NCT04331470</a>	Evaluation of Efficacy of Levamisole and Formoterol+Budesonide in Treatment of COVID-19	Iran	Y	N	Drug Repurposing	Levamisole, Budesonide/formoterol	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04440007">NCT04440007</a>	Study of the Efficacy and Safety of STI-5656 (Abivertinib Maleate) With SOC Versus SOC in Subjects With COVID-19	United States	Y	N	Shelved drug or NME	Abivertinib	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04423861">NCT04423861</a>	Efficacy and Safety of Nitazoxanide 600 mg TID for the Treatment of Hospitalized Patients With COVID-19	Brazil	Y	N	Drug Repurposing	Nitazoxanide	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04386252">NCT04386252</a>	Phase Ib-II Trial of Dendritic Cell Vaccine to Prevent COVID-19 in Adults	United States	Y	N	Vaccine	ND:Vaccine	Safety	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04356677">NCT04356677</a>	Study to Evaluate the Safety and Efficacy of VIRAZOLE  in Hospitalized Adult Participants With Respiratory Distress Due to COVID-19	United States	N	N	Drug Repurposing	Ribavirin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04313023">NCT04313023</a>	The Use PUL-042 to Reduce the Infection Rate and Progression to COVID-19 in Adults Exposed to SARS-CoV-2	United States	Y	N	Shelved drug or NME	PUL-042	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04409327">NCT04409327</a>	Phase 3 Study to Determine if RTB101 Reduces the Severity of COVID-19 in Older Adults Residing in Nursing Homes	United States	Y	N	Shelved drug or NME	RTB101	Efficacy - Other efficacy	Other	
<a href="https://ClinicalTrials.gov/show/NCT04336254">NCT04336254</a>	Safety and Efficacy Study of Allogeneic Human Dental Pulp Mesenchymal Stem Cells to Treat Severe COVID-19 Patients	China	Y	N	Cell/Blood based	ND:Stem cells	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04292899">NCT04292899</a>	Study to Evaluate the Safety and Antiviral Activity of Remdesivir (GS-5734 ) in Participants With Severe Coronavirus Disease (COVID-19)	United States	N	N	Shelved drug or NME	Remdesivir	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04416139">NCT04416139</a>	Mesenchymal Stem Cell for Acute Respiratory Distress Syndrome Due for COVID-19	Mexico	N	N	Cell/Blood based	ND:Stem cells	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04332094">NCT04332094</a>	Clinical Trial of Combined Use of Hydroxychloroquine, Azithromycin, and Tocilizumab for the Treatment of COVID-19	Brazil	Y	N	Drug Repurposing	Tocilizumab	Efficacy - Mortality	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04456595">NCT04456595</a>	Clinical Trial of Efficacy and Safety of Sinovac's Adsorbed COVID-19 (Inactivated) Vaccine in Healthcare Professionals	Brazil	Y	N	Vaccine	ND:Vaccine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04466280">NCT04466280</a>	Efficacy and Safety of Mucoadhesive Sustained Release, Mucodentol, in Comparison With Hydroxychloroquine to Prevent COVID-19	Iran	Y	N	Drug Repurposing, Shelved drug or NME	Hydroxychloroquine, Mucodentol	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04312997">NCT04312997</a>	The Use of PUL-042 Inhalation Solution to Reduce the Severity of COVID-19 in Adults Positive for SARS-CoV-2 Infection	United States	Y	N	Shelved drug or NME	PUL-042	Efficacy - WHO scale	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04385264">NCT04385264</a>	#StayHome: Early Hydroxychloroquine to Reduce Secondary Hospitalisation and Household Transmission in COVID-19	Switzerland	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04425460">NCT04425460</a>	A Multi-center,Randomized,Double-blind,Placebo-controlled,Phase 3 Study Evaluating Favipiravir in Treatment of COVID19	China	Y	N	Drug Repurposing	Favipiravir	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04370782">NCT04370782</a>	Hydroxychloroquine and Zinc With Either Azithromycin or Doxycycline for Treatment of COVID-19 in Outpatient Setting	United States	Y	N	Drug Repurposing	Hydroxychloroquine, Azithromycin, Zinc, Doxycycline	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04334980">NCT04334980</a>	Evaluating the Safety, Tolerability and Immunogenicity of bacTRL-Spike Vaccine for Prevention of COVID-19	Canada	Y	Y	Vaccine	bacTRL-Spike vaccine	Safety	Other	
<a href="https://ClinicalTrials.gov/show/NCT04478019">NCT04478019</a>	SHIELD Study: Using Naso-oropharyngeal Antiseptic Decolonization to Reduce COVID-19 Viral Shedding	United States	Y	N	Shelved drug or NME	Povidone-Iodine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04348409">NCT04348409</a>	Efficacy and Safety of Nitazoxanide for the Treatment of Hospitalized Patients With Moderate COVID-19	Brazil	Y	N	Drug Repurposing	Nitazoxanide	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04377711">NCT04377711</a>	A Study of the Safety and Efficacy of Ciclesonide in the Treatment of Non-hospitalized COVID-19 Patients	Switzerland	Y	N	Drug Repurposing	Ciclesonide	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04353518">NCT04353518</a>	Clinical Trial to Evaluate Mycobacterium w in Preventing COVID-19 in Subjects at Risk of Getting Infected With COVID-19	India	Y	N	Shelved drug or NME	ND:Mycobacterium	Efficacy - Infection rate (prevention)	General population	
<a href="https://ClinicalTrials.gov/show/NCT04429334">NCT04429334</a>	Safety, Tolerability and Efficacy of Nangibotide in Mechanically Ventilated Patients With COVID-19 and Features of Systemic Inflammation	France	Y	N	Shelved drug or NME	Nangibotide	Safety	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04328493">NCT04328493</a>	The Vietnam Chloroquine Treatment on COVID-19	Viet Nam	Y	N	Drug Repurposing	Chloroquine	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04360551">NCT04360551</a>	Pilot Clinical Trial of the Safety and Efficacy of Telmisartan for the Mitigation of Pulmonary and Cardiac Complications in COVID-19 Patients	United States	Y	N	Drug Repurposing	Telmisartan	Efficacy - WHO scale	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04343989">NCT04343989</a>	A Randomized Placebo-controlled Safety and Dose-finding Study for the Use of the IL-6 Inhibitor Clazakizumab in Patients With Life-threatening COVID-19 Infection	United States	Y	Y	Shelved drug or NME	Clazakizumab	Safety	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04348474">NCT04348474</a>	Efficacy and Safety of Hydroxychloroquine and Azithromycin for the Treatment of Ambulatory Patients With Mild COVID-19	Brazil	N	N	Drug Repurposing	Hydroxychloroquine, Azithromycin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04470531">NCT04470531</a>	Role of Co-trimoxazole in Severe COVID-19 Patients	Bangladesh	Y	N	Drug Repurposing	Trimethoprim/sulfamethoxazole	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04488575">NCT04488575</a>	Safety and Efficacy of EDP1815 in the Treatment of Patients Hospitalized With COVID-19 Infection	United States	Y	N	Shelved drug or NME	EDP1815	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04358809">NCT04358809</a>	Clinical Trial of Mycobacterium w in COVID-19 Positive Patients, Hospitalized But Not Critically Ill	India	Y	N	Vaccine	ND:Mycobacterium	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04492358">NCT04492358</a>	Treatment for Moderate/Severe COVID-19 in a Fragile and Vulnerable Population, Admitted to a Geriatric Hospital Unit or in a Transicional Care Center	Spain	Y	N	Drug Repurposing	Colchicine, Prednisone	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04348435">NCT04348435</a>	A Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Determine the Safety and Efficacy of Hope Biosciences Allogeneic Mesenchymal Stem Cell Therapy (HB-adMSCs) to Provide Protection Against COVID-19	United States	Y	Y	Cell/Blood based	ND:Stem cells	Efficacy - Other efficacy	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04329572">NCT04329572</a>	Efficacy and Safety of Hydroxychloroquine and Azithromycin for the Treatment of Hospitalized Patients With Moderate to Severe COVID-19	Brazil	N	N	Drug Repurposing	Hydroxychloroquine, Azithromycin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT03348670">NCT03348670</a>	Follow NCT03305341 - Proof-of-Concept - COVID-19 AP TP Vaccine	United States	N	N	Vaccine	ND:Vaccine	Other	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04292730">NCT04292730</a>	Study to Evaluate the Safety and Antiviral Activity of Remdesivir (GS-5734 ) in Participants With Moderate Coronavirus Disease (COVID-19) Compared to Standard of Care Treatment	United States	Y	Y	Shelved drug or NME	Remdesivir	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04431453">NCT04431453</a>	Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Efficacy of Remdesivir (GS-5734 ) in Participants From Birth to < 18 Years of Age With Coronavirus Disease 2019 (COVID-19)	United States	N	N	Shelved drug or NME	Remdesivir	Safety	Other	
<a href="https://ClinicalTrials.gov/show/NCT04358549">NCT04358549</a>	Study of the Use of Favipiravir in Hospitalized Subjects With COVID-19	United States	Y	N	Drug Repurposing	Favipiravir	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04482699">NCT04482699</a>	RAPA-501-Allo Off-the-Shelf Therapy of COVID-19	United States	Y	Y	Cell/Blood based	ND:MSC	Safety	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04481685">NCT04481685</a>	A Trial of Aclaris Therapeutics, Inc. (ATI)-450 in Patients With Moderate-severe Novel Coronavirus Disease 2019 (COVID-19)	United States	Y	N	Shelved drug or NME	ATI-450	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT03305341">NCT03305341</a>	Discovery Stage (Proof-of-concept) COVID-19 Antigen Presentation Therapeutic Vaccine	United States	N	N	Vaccine	ND:Vaccine	Other	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04428021">NCT04428021</a>	Standard or Convalescent Plasma in Patients With Recent Onset of COVID-19 Respiratory Failure	Italy	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04346615">NCT04346615</a>	Safety and Efficacy Trial of Zavegepant* Intranasal for Hospitalized Patients With COVID-19 Requiring Supplemental Oxygen	United States	Y	N	Shelved drug or NME	Vazegepant	Safety	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04428268">NCT04428268</a>	Chloroquine + Losartan Compared to Chloroquine Alone for the Treatment of COVID-19 Pneumonia	Mexico	Y	N	Drug Repurposing	Losartan	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04360824">NCT04360824</a>	Covid-19 Associated Coagulopathy	United States	Y	N	Drug Repurposing	Enoxaparin	Efficacy - Mortality	General population, Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04463264">NCT04463264</a>	Efficacy and Safety Study of Nitazoxanide (NTX) in the Treatment of Patients With SARS-CoV-2 Virus Infection (COVID-19)	Argentina	Y	N	Drug Repurposing	Nitazoxanide	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04368728">NCT04368728</a>	Study to Describe the Safety, Tolerability, Immunogenicity, and Efficacy of RNA Vaccine Candidates Against COVID-19 in Healthy Adults	United States	Y	Y	Shelved drug or NME	BNT162b1, BNT162b2	Safety	General population	
<a href="https://ClinicalTrials.gov/show/NCT04415060">NCT04415060</a>	SedAting With Volatile Anesthetics Critically Ill COVID-19 Patients in ICU: Effects On Ventilatory Parameters And Survival	Canada	Y	N	Drug Repurposing	Isoflurane, Sevoflurane	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04349410">NCT04349410</a>	The Fleming [FMTVDM] Directed CoVid-19 Treatment Protocol	United States	Y	Y	Drug Repurposing, Shelved drug or NME, Cell/Blood based	Hydroxychloroquine, Azithromycin, Doxycycline, Clindamycin, Primaquine, Remdesivir, Tocilizumab, Methylprednisolone, Losartan, ND:Convalescent plasma, Interferon alpha-2b	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04387760">NCT04387760</a>	Favipiravir vs Hydroxychloroquine in COVID -19	Bahrain	Y	Y	Drug Repurposing	Hydroxychloroquine, Favipiravir	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04460651">NCT04460651</a>	PREPARE-IT. Prevention of COVID19 With EPA in Healthcare Providers at Risk - Intervention Trial	Argentina	Y	N	Drug Repurposing	Icosapent ethyl	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04364802">NCT04364802</a>	COVID-19: Povidone-Iodine Intranasal Prophylaxis in Front-line Healthcare Personnel and Inpatients	United States	N	N	Shelved drug or NME	Povidone-Iodine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04315896">NCT04315896</a>	Hydroxychloroquine Treatment for Severe COVID-19 Pulmonary Infection (HYDRA Trial)	Mexico	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04408209">NCT04408209</a>	Convalescent Plasma for the Treatment of Patients With Severe COVID-19 Infection	Greece	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04323514">NCT04323514</a>	Use of Ascorbic Acid in Patients With COVID 19	Italy	N	N	Drug Repurposing	Ascorbic acid	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04273646">NCT04273646</a>	Study of Human Umbilical Cord Mesenchymal Stem Cells in the Treatment of Severe COVID-19	China	N	N	Cell/Blood based	ND:Stem cells	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04381858">NCT04381858</a>	Convalescent Plasma vs Human Immunoglobulin to Treat COVID-19 Pneumonia	Mexico	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04494646">NCT04494646</a>	BARCONA: A Study of Effects of Bardoxolone Methyl in Participants With SARS-Corona Virus-2 (COVID-19)	United States	Y	N	Shelved drug or NME	Bardoxolone	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04461925">NCT04461925</a>	Treatment of Coronavirus COVID-19 Pneumonia (Pathogen SARS-CoV-2) With Cryopreserved Allogeneic P_MMSCs and UC-MMSCs	Ukraine	N	N	Cell/Blood based	ND:MSC	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04477083">NCT04477083</a>	Development and Validation of "Ready-to-Use" Inhalable Forms of Hydroxychloroquine for Treatment of COVID-19	Egypt	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04362137">NCT04362137</a>	Phase 3 Randomized, Double-blind, Placebo-controlled Multi-center Study to Assess the Efficacy and Safety of Ruxolitinib in Patients With COVID-19 Associated Cytokine Storm (RUXCOVID)	United States	Y	N	Drug Repurposing	Ruxolitinib	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04305106">NCT04305106</a>	Bevacizumab in Severe or Critically Severe Patients With COVID-19 Pneumonia-RCT	China	Y	N	Drug Repurposing	Bevacizumab	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04315987">NCT04315987</a>	NestaCell  Mesenchymal Stem Cell to Treat Patients With Severe COVID-19 Pneumonia	Brazil	N	N	Cell/Blood based	ND:Stem cells	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04460105">NCT04460105</a>	Lanadelumab in Participants Hospitalized With COVID-19 Pneumonia	United States	Y	N	Drug Repurposing	Lanadelumab	Safety	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04354870">NCT04354870</a>	COVID-19 PrEP HCW HCQ Study	United States	N	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04244591">NCT04244591</a>	Glucocorticoid Therapy for COVID-19 Critically Ill Patients With Severe Acute Respiratory Failure	China	Y	N	Drug Repurposing	Methylprednisolone	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04342663">NCT04342663</a>	A Double-blind, Placebo-controlled Clinical Trial of Fluvoxamine for Symptomatic Individuals With COVID-19 Infection	United States	Y	N	Drug Repurposing	Fluvoxamine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04325061">NCT04325061</a>	Efficacy of Dexamethasone Treatment for Patients With ARDS Caused by COVID-19	Spain	Y	N	Drug Repurposing	Dexamethasone	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04320615">NCT04320615</a>	A Study to Evaluate the Safety and Efficacy of Tocilizumab in Patients With Severe COVID-19 Pneumonia	United States	Y	N	Drug Repurposing	Tocilizumab	Efficacy - WHO scale	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04344730">NCT04344730</a>	Dexamethasone and Oxygen Support Strategies in ICU Patients With Covid-19 Pneumonia	France	Y	Y	Drug Repurposing, Other	Dexamethasone, ND:Procedure	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04372186">NCT04372186</a>	A Study to Evaluate the Efficacy and Safety of Tocilizumab in Hospitalized Participants With COVID-19 Pneumonia	United States	Y	N	Drug Repurposing	Tocilizumab	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04407130">NCT04407130</a>	Efficacy and Safety of Ivermectin and Doxycycline in Combination or IVE Alone in Patients With COVID-19 Infection.	Bangladesh	Y	Y	Drug Repurposing	Ivermectin, Doxycycline	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04386616">NCT04386616</a>	A Study to Evaluate the Safety and Efficacy of MSTT1041A (Astegolimab) or UTTR1147A in Patients With Severe COVID-19 Pneumonia	United States	Y	N	Shelved drug or NME	Astegolimab	Efficacy - WHO scale	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04332107">NCT04332107</a>	Azithromycin for COVID-19 Treatment in Outpatients Nationwide	United States	Y	N	Drug Repurposing	Azithromycin	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04363736">NCT04363736</a>	A Study to Investigate Intravenous Tocilizumab in Participants With Moderate to Severe COVID-19 Pneumonia	United States	Y	N	Drug Repurposing	Tocilizumab	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04363060">NCT04363060</a>	Azithromycin+Amoxicillin/Clavulanate vs Amoxicillin/Clavulanate in COVID19 Patients With Pneumonia in Non-intensive Unit	France	Y	N	Drug Repurposing	Azithromycin, Amoxicillin/clavulanate	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04371640">NCT04371640</a>	Sirolimus in COVID-19 Phase 1	United States	Y	N	Drug Repurposing	Sirolimus	Efficacy - Viral load	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04455815">NCT04455815</a>	A Trial Looking at the Use of Camostat to Reduce Progression of Symptoms of Coronavirus (COVID-19) in People Who Have Tested Positive But Are Able to Stay at Home	United Kingdom	Y	N	Drug Repurposing	Camostat	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04417257">NCT04417257</a>	Study of LAU-7b for the Treatment of COVID-19 Disease in Adults	Canada	Y	N	Shelved drug or NME	LAU-7b	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04273529">NCT04273529</a>	The Efficacy and Safety of Thalidomide in the Adjuvant Treatment of Moderate New Coronavirus (COVID-19) Pneumonia	China	Y	N	Drug Repurposing	Thalidomide	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04273581">NCT04273581</a>	The Efficacy and Safety of Thalidomide Combined With Low-dose Hormones in the Treatment of Severe COVID-19	China	Y	N	Drug Repurposing	Thalidomide	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04409262">NCT04409262</a>	A Study to Evaluate the Efficacy and Safety of Remdesivir Plus Tocilizumab Compared With Remdesivir Plus Placebo in Hospitalized Participants With Severe COVID-19 Pneumonia	United States	Y	N	Drug Repurposing	Tocilizumab	Efficacy - WHO scale	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04335201">NCT04335201</a>	Defibrotide in COVID-19 Pneumonia	Italy	N	N	Drug Repurposing	Defibrotide	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04379336">NCT04379336</a>	BCG Vaccination for Healthcare Workers in COVID-19 Pandemic	South Africa	Y	N	Drug Repurposing	BCG Vaccine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04283461">NCT04283461</a>	Safety and Immunogenicity Study of 2019-nCoV Vaccine (mRNA-1273) for Prophylaxis of SARS-CoV-2 Infection (COVID-19)	United States	N	Y	Vaccine	ND:Vaccine	Safety	General population	
<a href="https://ClinicalTrials.gov/show/NCT04374032">NCT04374032</a>	Clinical Trial to Evaluate the Efficacy and Safety of an Immunomodulatory Therapy for the Treatment of Patients With Moderate to Severe COVID-19 Infection	Bosnia and Herzegovina	Y	N	Drug Repurposing	Metenkefalin, Tridecactide	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04359680">NCT04359680</a>	Trial to Evaluate the Efficacy and Safety of Nitazoxanide (NTZ) for Post Exposure Prophylaxis of COVID-19 and Other Viral Respiratory Illnesses (VRI) in Healthcare Workers	United States	Y	N	Drug Repurposing	Nitazoxanide	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04334044">NCT04334044</a>	Treatment of SARS Caused by COVID-19 With Ruxolitinib	Mexico	N	N	Drug Repurposing	Ruxolitinib	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04342221">NCT04342221</a>	Hydroxychloroquine for COVID-19	Germany	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04362124">NCT04362124</a>	Performance Evaluation of BCG Vaccination in Healthcare Personnel to Reduce the Severity of SARS-COV-2 Infection	Colombia	Y	N	Drug Repurposing	BCG Vaccine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04365127">NCT04365127</a>	Progesterone for the Treatment of COVID-19 in Hospitalized Men	United States	Y	N	Drug Repurposing	Progesterone	Efficacy - WHO scale	Severe Cases, Other	
<a href="https://ClinicalTrials.gov/show/NCT04382053">NCT04382053</a>	Study of Efficacy and Safety of DV890 in Patients With COVID-19 Pneumonia	United States	Y	N	Shelved drug or NME	DFV890	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04353271">NCT04353271</a>	Trial of Hydroxychloroquine In Covid-19 Kinetics	United States	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04343248">NCT04343248</a>	Trial to Evaluate the Efficacy and Safety of Nitazoxanide (NTZ) for Post-Exposure Prophylaxis of COVID-19 and Other Viral Respiratory Illnesses in Elderly Residents of Long-Term Care Facilities (LTCF)	United States	Y	N	Drug Repurposing	Nitazoxanide	Efficacy - Infection rate (prevention)	Other	
<a href="https://ClinicalTrials.gov/show/NCT04372017">NCT04372017</a>	Hydroxychloroquine as Post-Exposure Prophylaxis Against COVID-19 Infection	United States	Y	Y	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04449380">NCT04449380</a>	Clinical Study for the Treatment With Interferon- -1a (IFN -1a) of COVID-19 Patients	Italy	Y	N	Drug Repurposing	Interferon beta-1a	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04363203">NCT04363203</a>	VA Remote and Equitable Access to COVID-19 Healthcare Delivery (VA-REACH TRIAL)	United States	Y	Y	Drug Repurposing	Hydroxychloroquine, Azithromycin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Other	
<a href="https://ClinicalTrials.gov/show/NCT04341207">NCT04341207</a>	Epidemiology of SARS-CoV-2 and Mortality to Covid19 Disease in French Cancer Patients	France	N	N	Drug Repurposing	Hydroxychloroquine, Azithromycin	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04469179">NCT04469179</a>	Safety, Tolerability, and Pharmacokinetics of SAB-185 in Ambulatory Participants With COVID-19	United States	Y	Y	Shelved drug or NME	SAB-185	Safety	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04252664">NCT04252664</a>	A Trial of Remdesivir in Adults With Mild and Moderate COVID-19	China	Y	N	Shelved drug or NME	Remdesivir	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04413838">NCT04413838</a>	Efficiency and Security of NIVOLUMAB Therapy in Obese Individuals With COVID-19(COrona VIrus Disease) Infection	France	Y	N	Drug Repurposing	Nivolumab	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases, Other	
<a href="https://ClinicalTrials.gov/show/NCT04446065">NCT04446065</a>	Protection of Health Workers Against COVID-19	Chile	Y	N	Shelved drug or NME	Previfenon	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04405921">NCT04405921</a>	Hydroxychloroquine, Azithromycin in the Treatment of Covid-19	Tunisia	N	N	Drug Repurposing	Azithromycin, Hydroxychloroquine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04346628">NCT04346628</a>	Oral Favipiravir Compared to Placebo in Subjects With Mild COVID-19	United States	Y	N	Drug Repurposing	Favipiravir	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04377646">NCT04377646</a>	A Study of Hydroxychloroquine and Zinc in the Prevention of COVID-19 Infection in Military Healthcare Workers	Tunisia	Y	N	Drug Repurposing	Hydroxychloroquine, Zinc	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP), Other	
<a href="https://ClinicalTrials.gov/show/NCT04382651">NCT04382651</a>	Study of Efficacy and Safety of MAS825 in Patients With COVID-19	United States	Y	N	Shelved drug or NME	MAS825	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04362813">NCT04362813</a>	Study of Efficacy and Safety of Canakinumab Treatment for CRS in Participants With COVID-19-induced Pneumonia	United States	Y	N	Drug Repurposing	Canakinumab	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04452643">NCT04452643</a>	Efficacy of BACMUNE (MV130) in the Prevention of Disease Due to COVID-19 Infection in Healthcare Personnel	Mexico	Y	N	Shelved drug or NME	MV130	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04494984">NCT04494984</a>	A Study to Investigate the Pharmacokinetics, Efficacy and Safety of INM005 in Patients With COVID-19.	Argentina	Y	N	Shelved drug or NME	INM005	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04470297">NCT04470297</a>	Melatonin Agonist on Hospitalized Patients With Confirmed or Suspected COVID-19	Brazil	Y	N	Drug Repurposing	Ramelteon	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04358068">NCT04358068</a>	Evaluating the Efficacy of Hydroxychloroquine and Azithromycin to Prevent Hospitalization or Death in Persons With COVID-19	United States	Y	N	Drug Repurposing	Hydroxychloroquine, Azithromycin	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04437875">NCT04437875</a>	An Open Study of the Safety, Tolerability and Immunogenicity of "Gam-COVID-Vac Lyo" Vaccine Against COVID-19	Russian Federation	N	N	Vaccine	ND:Gam-COVID-Vac Lyo Vaccine	Efficacy - Other efficacy	General population	
<a href="https://ClinicalTrials.gov/show/NCT04470609">NCT04470609</a>	Safety and Immunogenicity Study of an Inactivated SARS-CoV-2 Vaccine for Preventing Against COVID-19 in People Aged ?60 Years	China	Y	Y	Vaccine	Inactivated SARS-CoV-2 vaccine	Safety	General population	
<a href="https://ClinicalTrials.gov/show/NCT04435808">NCT04435808</a>	Efficacy of Hydroxychloroquine Prophylaxis for Health Care Workers at High Risk for COVID-19	United States	N	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04400032">NCT04400032</a>	Cellular Immuno-Therapy for COVID-19 Acute Respiratory Distress Syndrome - Vanguard	Canada	N	N	Cell/Blood based	ND:MSC	Safety	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04354259">NCT04354259</a>	Interferon Lambda for Immediate Antiviral Therapy at Diagnosis in COVID-19	Canada	Y	Y	Shelved drug or NME	Interferon lambda	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04352608">NCT04352608</a>	Safety and Immunogenicity Study of Inactivated Vaccine for Prophylaxis of SARS CoV-2 Infection (COVID-19)	China	Y	Y	Vaccine	ND:Vaccine	Safety	General population	
<a href="https://ClinicalTrials.gov/show/NCT04383574">NCT04383574</a>	Safety and Immunogenicity Study of Inactivated Vaccine for Prevention of SARS-CoV-2 Infection(COVID-19)	China	Y	N	Vaccine	ND:Vaccine	Safety	General population	
<a href="https://ClinicalTrials.gov/show/NCT04280588">NCT04280588</a>	Fingolimod in COVID-19	China	Y	N	Drug Repurposing	Fingolimod	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04344457">NCT04344457</a>	Evaluate the Efficacy and Safety of Oral Hydroxychloroquine, Indomethacin and Zithromax in Subjects With Mild Symptoms of COVID-19	United States	N	N	Drug Repurposing	Hydroxychloroquine, Indomethacin, Azithromycin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04351919">NCT04351919</a>	Assessment of Efficacy and Safety of HCQ and Antibiotics Administrated to Patients COVID19(+)	Tunisia	N	N	Drug Repurposing	Hydroxychloroquine, Azithromycin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04336332">NCT04336332</a>	Randomized Comparison of Combination Azithromycin and Hydroxychloroquine vs. Hydroxychloroquine Alone for the Treatment of Confirmed COVID-19	United States	Y	Y	Drug Repurposing	Hydroxychloroquine, Azithromycin	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04368988">NCT04368988</a>	Evaluation of the Safety and Immunogenicity of a SARS-CoV-2 rS (COVID-19) Nanoparticle Vaccine With/Without Matrix-M Adjuvant	Australia	Y	N	Shelved drug or NME	SARS-CoV-2 rS Vaccine, Matrix-M Adjuvant	Safety	General population	
<a href="https://ClinicalTrials.gov/show/NCT04486482">NCT04486482</a>	A Clinical Study to Assess the Physiologic Effects of KB109 in Patients With COVID-19 on Gut Microbiota Structure and Function	United States	Y	N	Shelved drug or NME	KB109	Safety	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04366271">NCT04366271</a>	Clinical Trial of Allogeneic Mesenchymal Cells From Umbilical Cord Tissue in Patients With COVID-19	Spain	Y	N	Cell/Blood based	ND:Stem cells	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04422678">NCT04422678</a>	The Safety & Efficacy of Imatinib for the Treatment of SARS-COV-2 Induced Pneumonia	Egypt	Y	N	Drug Repurposing	Imatinib	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04333472">NCT04333472</a>	Piclidenoson for Treatment of COVID-19	Israel	Y	N	Shelved drug or NME	Piclidenoson	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04392128">NCT04392128</a>	Study Evaluating the Efficacy of Hydroxychloroquine and Azithromycine in Patients With COVID-19 and Hematological Malignancies (HYACINTHE)	France	Y	N	Drug Repurposing	Hydroxychloroquine, Azithromycin	Efficacy - Viral load	Other	
<a href="https://ClinicalTrials.gov/show/NCT04414124">NCT04414124</a>	A Clinical Study to Assess the Natural History of COVID-19 and Effects of KB109 and Supportive Self-care in Outpatients With Mild-to-moderate COVID-19	United States	Y	N	Shelved drug or NME	KB109	Safety	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04389944">NCT04389944</a>	Amotosalen-Ultraviolet A Pathogen-Inactivated Convalescent Plasma in Addition to Best Supportive Care and Antiviral Therapy on Clinical Deterioration in Adults Presenting With Moderate to Severe COVID-19	Switzerland	N	N	Cell/Blood based	ND:Convalescent plasma	Safety	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT03891420">NCT03891420</a>	A Study to Evaluate the Safety, Pharmacokinetics and Antiviral Effects of Galidesivir in Yellow Fever or COVID-19	Brazil	Y	N	Shelved drug or NME	Galidesivir	Safety	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04397523">NCT04397523</a>	Efficacy and Safety of COVID-19 Convalescent Plasma	Macedonia, the former Yugoslav Republic of	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04351152">NCT04351152</a>	Phase 3 Study to Evaluate Efficacy and Safety of Lenzilumab in Patients With COVID-19	United States	Y	N	Shelved drug or NME	Lenzilumab	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04394208">NCT04394208</a>	Silymarin in COVID-19 Pneumonia	Egypt	Y	N	Drug Repurposing	Silymarin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04303299">NCT04303299</a>	Various Combination of Protease Inhibitors, Oseltamivir, Favipiravir, and Hydroxychloroquine for Treatment of COVID-19 : A Randomized Control Trial	Thailand	Y	Y	Drug Repurposing, Shelved drug or NME	Oseltamivir, Hydroxychloroquine, Darunavir, Lopinavir/ritonavir, Favipiravir	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04334005">NCT04334005</a>	Vitamin D on Prevention and Treatment of COVID-19	Spain	Y	N	Drug Repurposing	Vitamin D3	Efficacy - Mortality	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04346446">NCT04346446</a>	Efficacy of Convalescent Plasma Therapy in Severely Sick COVID-19 Patients	India	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04357457">NCT04357457</a>	Efficacy of Intravenous Almitrine in Reducing the Need for Mechanical Ventilation in Patients With Hypoxemic Acute Respiratory Failure Due to Covid-19-related Pneumonia	France	Y	N	Drug Repurposing	Almitrine	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04456049">NCT04456049</a>	Randomized Open Label Phase II Study to Evaluate the Efficacy of Enzalutamide in High Risk Male Outpatients With COVID-19	Switzerland	Y	N	Drug Repurposing	Enzalutamide	Efficacy - Clinical improvement (except WHO scale)	Other	
<a href="https://ClinicalTrials.gov/show/NCT04405271">NCT04405271</a>	TAF/FTC for Pre-exposure Prophylaxis of COVID-19 in Healthcare Workers (CoviPrep Study)	Argentina	Y	N	Drug Repurposing	Emtricitabine/Tenofovir Alafenamide	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04348877">NCT04348877</a>	Plasma Rich Antibodies From Recovered Patients From COVID19	Egypt	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Viral load	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04344951">NCT04344951</a>	Chloroquine Phosphate Against Infection by the Novel Coronavirus SARS-CoV-2 (COVID-19): The HOPE Open-Label, Non Randomized Clinical Trial	Greece	N	N	Drug Repurposing	Chloroquine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04487574">NCT04487574</a>	A Study to Assess the Efficacy and Safety of XC221 in Patients With COVID-19	Russian Federation	Y	N	Shelved drug or NME	XC221	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04349241">NCT04349241</a>	Efficacy and Safety of Favipiravir in Management of COVID-19	Egypt	Y	N	Drug Repurposing	Favipiravir	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04360876">NCT04360876</a>	Targeted Steroids for ARDS Due to COVID-19 Pneumonia: A Pilot Randomized Clinical Trial	United States	Y	N	Drug Repurposing	Dexamethasone	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04452812">NCT04452812</a>	Statistical and Epidemiological Study Based on the Use of Convalescent Plasma for the Management of Patients With COVID-19	Mexico	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04362176">NCT04362176</a>	Passive Immunity Trial of Nashville II for COVID-19	United States	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04331600">NCT04331600</a>	Chloroquine as Antiviral Treatment in Coronavirus Infection 2020	Poland	Y	N	Drug Repurposing	Chloroquine	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04409925">NCT04409925</a>	DISmantling COvid iNduced Neutrophil ExtraCellular Traps (DISCONNECT-1)	Canada	N	N	Drug Repurposing	Dornase alfa	Safety	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04342897">NCT04342897</a>	A Study of LY3127804 in Participants With COVID-19	United States	Y	N	Shelved drug or NME	LY3127804	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04487886">NCT04487886</a>	Duvelisib Ameliorates Manifestations of Pneumonia in Established Novel Coronavirus Infection (COVID-19)	United States	Y	N	Drug Repurposing	Duvelisib	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04377308">NCT04377308</a>	Fluoxetine to Reduce Intubation and Death After COVID19 Infection	United States	N	N	Drug Repurposing	Fluoxetine	Efficacy - Infection rate (prevention)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04360122">NCT04360122</a>	Levamisole and Isoprinosine in Immune-prophylaxis of Egyptian Healthcare Workers Facing COVID-19	Egypt	Y	N	Drug Repurposing	Levamisole, Isoprinosine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04354428">NCT04354428</a>	Treatment for COVID-19 in High-Risk Adult Outpatients	United States	Y	Y	Drug Repurposing	Hydroxychloroquine, Ascorbic acid, Folic acid, Azithromycin	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04350736">NCT04350736</a>	First in Human SAD and MAD Study of Inhaled TD-0903, a Potential Treatment for ALI Associated With COVID-19	United Kingdom	Y	N	Shelved drug or NME	TD-0903	Safety	General population	
<a href="https://ClinicalTrials.gov/show/NCT04347681">NCT04347681</a>	Potential Efficacy of Convalescent Plasma to Treat Severe COVID-19 and Patients at High Risk of Developing Severe COVID-19	Saudi Arabia	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04348513">NCT04348513</a>	Triiodothyronine for the Treatment of Critically Ill Patients With COVID-19 Infection	Greece	Y	N	Drug Repurposing	Triiodothyronine	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04341116">NCT04341116</a>	Study of TJ003234 (Anti-GM-CSF Monoclonal Antibody) in Subjects With Severe Coronavirus Disease 2019 (COVID-19)	United States	Y	Y	Shelved drug or NME	TJ003234 (Anti-GM-CSF Monoclonal Antibody)	Efficacy - WHO scale	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04377568">NCT04377568</a>	Efficacy of Human Coronavirus-immune Convalescent Plasma for the Treatment of COVID-19 Disease in Hospitalized Children	Canada	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Clinical improvement (except WHO scale)	Other	
<a href="https://ClinicalTrials.gov/show/NCT04373460">NCT04373460</a>	Convalescent Plasma to Limit SARS-CoV-2 Associated Complications	United States	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Mortality	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04350931">NCT04350931</a>	Application of BCG Vaccine for Immune-prophylaxis Among Egyptian Healthcare Workers During the Pandemic of COVID-19	Egypt	Y	N	Drug Repurposing	BCG Vaccine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04458363">NCT04458363</a>	Convalescent Plasma in Pediatric COVID-19	United States	N	N	Cell/Blood based	ND:Convalescent plasma	Safety	Other	
<a href="https://ClinicalTrials.gov/show/NCT04373044">NCT04373044</a>	Baricitinib, Placebo and Antiviral Therapy for the Treatment of Patients With Moderate and Severe COVID-19	United States	N	N	Drug Repurposing, Shelved drug or NME	Baricitinib, Hydroxychloroquine	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04389840">NCT04389840</a>	Dociparstat for the Treatment of Severe COVID-19 in Adults at High Risk of Respiratory Failure	United States	Y	N	Shelved drug or NME	Dociparastat	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04447469">NCT04447469</a>	Study of Mavrilimumab (KPL-301) in Participants Hospitalized With Severe Corona Virus Disease 2019 (COVID-19) Pneumonia and Hyper-inflammation	United States	Y	N	Shelved drug or NME	Mavrilimumab	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04341389">NCT04341389</a>	A Phase II Clinical Trial to Evaluate the Recombinant Vaccine for COVID-19 (Adenovirus Vector)	China	Y	Y	Vaccine	ND:Vaccine	Safety	General population	
<a href="https://ClinicalTrials.gov/show/NCT04359654">NCT04359654</a>	Nebulised Dornase Alfa for Treatment of COVID-19	United Kingdom	Y	N	Drug Repurposing	Dornase alfa	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04468971">NCT04468971</a>	REgulatory T Cell infuSion fOr Lung Injury Due to COVID-19 PnEumonia	United States	Y	Y	Shelved drug or NME	CK0802	Safety	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04491994">NCT04491994</a>	Clearing the Fog: Is Hydroxychloroquine Effective in Reducing COVID-19 Progression	Pakistan	Y	N	Drug Repurposing	Hydoxychloroquine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04413864">NCT04413864</a>	Immunomodulatory Profile of Dexmedetomidine Sedation in Patients Recovering After ARDS Covid-19	France	N	N	Drug Repurposing	Dexmedetomidine	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04374526">NCT04374526</a>	Early transfusIon of Convalescent Plasma in Elderly COVID-19 Patients. to Prevent Disease Progression.	Italy	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04375098">NCT04375098</a>	Efficacy and Safety of Early COVID-19 Convalescent Plasma in Patients Admitted for COVID-19 Infection	Chile	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04317040">NCT04317040</a>	CD24Fc as a Non-antiviral Immunomodulator in COVID-19 Treatment	United States	Y	N	Shelved drug or NME	CD24Fc	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04409509">NCT04409509</a>	Treatment With CSL312 in Adults With Coronavirus Disease 2019 (COVID-19)	United States	Y	N	Shelved drug or NME	Garadacimab	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04326790">NCT04326790</a>	The GReek Study in the Effects of Colchicine in Covid-19 cOmplications Prevention	Greece	Y	N	Drug Repurposing	Colchicine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04339816">NCT04339816</a>	Azithromycin Added to Hydrochloroquine in Patients Admitted to Intensive Care With COVID-19: Randomised Controlled Trial	Czech Republic	Y	N	Drug Repurposing	Azithromycin, Hydroxychloroquine	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04453488">NCT04453488</a>	Clinical Trial to Evaluate the Efficacy of RUTI  Against SARS-COV-2 Infection (COVID-19) in Healthcare Workers	Spain	Y	N	Vaccine	ND:RUTI Vaccine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04349371">NCT04349371</a>	Saved From COVID-19	United States	Y	N	Drug Repurposing	Chloroquine	Efficacy - Other efficacy	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04364893">NCT04364893</a>	Angiotensin Receptor Blockers and Angiotensin-converting Enzyme Inhibitors and Adverse Outcomes in Patients With COVID19	Brazil	Y	N	Drug Repurposing	Angiotensin Receptor Blockers, Angiotensin-converting Enzyme Inhibitors	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04351516">NCT04351516</a>	Test and Treat COVID 65plus+	Germany	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04451291">NCT04451291</a>	Study of Decidual Stromal Cells to Treat COVID-19 Respiratory Failure	Canada	N	N	Cell/Blood based	ND:Decidual Stromal Cells	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04345653">NCT04345653</a>	Hydroxychloroquine as Chemoprevention for COVID-19 for High Risk Healthcare Workers	United States	N	N	Drug Repurposing	Hydroxychloroquine	Other	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04468646">NCT04468646</a>	To Determine the Efficacy of Neurokinin 1 Receptor Antagonist as a Therapeutic Tool Against Cytokine Storm and Respiratory Failure in Covid-19 Patients	Pakistan	Y	N	Drug Repurposing	Aprepitant	Efficacy - WHO scale	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04331054">NCT04331054</a>	Protective Role of Inhaled Steroids for Covid-19 Infection	France	Y	N	Drug Repurposing	Budesonide/formoterol	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04358406">NCT04358406</a>	Rhu-pGSN for Severe Covid-19 Pneumonia	United States	Y	N	Shelved drug or NME	Recombinant human plasma gelsolin	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04346368">NCT04346368</a>	Bone Marrow-Derived Mesenchymal Stem Cell Treatment for Severe Patients With Coronavirus Disease 2019 (COVID-19)	China	Y	N	Cell/Blood based	ND:Stem cells	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04392973">NCT04392973</a>	FAvipiravir and HydroxyChloroquine Combination Therapy	Saudi Arabia	Y	N	Drug Repurposing	Favipiravir, Hydroxychloroquine	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04396067">NCT04396067</a>	Combination With Inhibitor of Neutrophil Elastase (All-trans Retinoic Acid ) and Isotretinoin May Enhances Neutralizing Antibodies in COVID -19 Infected Patients Better Than COVID-19 Inactivated Vaccines	Egypt	Y	N	Drug Repurposing	Alvelestat, Isotretinoin	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04335071">NCT04335071</a>	Tocilizumab in the Treatment of Coronavirus Induced Disease (COVID-19)	Switzerland	Y	N	Drug Repurposing	Tocilizumab	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04395170">NCT04395170</a>	Convalescent Plasma (PC) and Human Intravenous Anti-COVID-19 Immunoglobulin (IV Anti COVID-19 IgG) in Patients Hospitalized for COVID-19.	Colombia	Y	Y	Cell/Blood based	ND:Convalescent plasma, ND:Human Immunoglobulin	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04459676">NCT04459676</a>	Study to Assess Efficacy and Safety Relative to Standard of Care in Patients With COVID-19 Pneumonia	Brazil	Y	N	Shelved drug or NME	ANG-3777	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04345276">NCT04345276</a>	Efficacy and Safety of Ganovo (Danoprevir) Combined With Ritonavir in the Treatment of SARS-CoV-2 Infection	China	N	N	Drug Repurposing, Shelved drug or NME	Danoprevir, Ritonavir	Efficacy - Oxygen parameters	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04291729">NCT04291729</a>	Evaluation of Ganovo (Danoprevir ) Combined With Ritonavir in the Treatment of SARS-CoV-2 Infection	China	N	N	Drug Repurposing, Shelved drug or NME	Danoprevir, Ritonavir, Interferon(NOS)	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04338906">NCT04338906</a>	Combination Therapy With Camostat Mesilate + Hydroxychloroquine for COVID-19	Germany	Y	N	Drug Repurposing	Camostat	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04386447">NCT04386447</a>	Phase II RCT to Assess Efficacy of Intravenous Administration of Oxytocin in Patients Affected by COVID-19	Italy	Y	Y	Drug Repurposing	Oxytocin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04286503">NCT04286503</a>	The Clinical Study of Carrimycin on Treatment Patients With COVID-19	China	Y	N	Shelved drug or NME	Carrimycin	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04380376">NCT04380376</a>	Low-doses Melphalan Inhalation in Patients With COVID-19 (CoronavIrus Disease 2019) Pneumonia	Russian Federation	N	N	Drug Repurposing	Melphalan	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04288102">NCT04288102</a>	Treatment With Human Umbilical Cord-derived Mesenchymal Stem Cells for Severe Corona Virus Disease 2019 (COVID-19)	China	Y	N	Cell/Blood based	ND:Stem cells	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04352803">NCT04352803</a>	Adipose Mesenchymal Cells for Abatement of SARS-CoV-2 Respiratory Compromise in COVID-19 Disease	United States	N	N	Cell/Blood based	ND:MSCs	Safety	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04350580">NCT04350580</a>	Polyvalent Immunoglobulin in COVID-19 Related ARds	France	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04487990">NCT04487990</a>	CoV-Hep Study: Regional Anticoagulation Modalities in Continuous Venous Venous Hemodialysis in Patients With COVID-19	Brazil	Y	N	Drug Repurposing	Heparin	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04466241">NCT04466241</a>	Combination Therapies to Reduce Carriage of SARS-Cov-2 and Improve Outcome of COVID-19 in Ivory Coast: a Phase Randomized IIb Trial	Ivory Coast	Y	Y	Drug Repurposing	Telmisartan, Atorvastatin	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04428073">NCT04428073</a>	Therapeutic Vaccine Trial of COVID-19 for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection	United States	Y	Y	Vaccine	ND:Vaccine	Safety	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04365582">NCT04365582</a>	OUTpatient Treatment of COVID-19 in Patients With Risk Factor for Poor Outcome	France	Y	N	Drug Repurposing	Azithromycin, Hydroxychloroquine, Lopinavir/ritonavir	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04353674">NCT04353674</a>	Modulation of Hyperinflammation in COVID-19	United States	Y	N	Cell/Blood based	ND:Neutrophil modulation	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04473261">NCT04473261</a>	Efficacy of Iodine Complex Against COVID-19 Patients	Pakistan	Y	Y	Shelved drug or NME	Iodine complex	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04348305">NCT04348305</a>	Hydrocortisone for COVID-19 and Severe Hypoxia	Denmark	Y	N	Drug Repurposing	Hydrocortisone	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04407286">NCT04407286</a>	Vitamin D Testing and Treatment for COVID 19	United States	N	N	Drug Repurposing	Vitamin D3	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04401410">NCT04401410</a>	Anti-SARS Cov-2 T Cell Infusions for COVID 19	United States	N	N	Cell/Blood based	ND:T-cells	Safety	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04344600">NCT04344600</a>	Peginterferon Lambda-1a for the Prevention and Treatment of SARS-CoV-2 (COVID-19) Infection	United States	Y	N	Shelved drug or NME	Peg-Interferon lambda-1a	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04377503">NCT04377503</a>	Tocilizumab Versus Methylprednisolone in the Cytokine Release Syndrome of Patients With COVID-19	Brazil	Y	N	Drug Repurposing	Tocilizumab	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04395456">NCT04395456</a>	A Phase 2 Study of the C3 Inhibitor AMY-101 in Patients With ARDS Due to COVID-19 (SAVE)	Greece	Y	N	Shelved drug or NME	AMY-101	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04335305">NCT04335305</a>	Checkpoint Blockade in COVID-19 Pandemic	Spain	Y	N	Drug Repurposing	Pembrolizumab, Tocilizumab	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04372589">NCT04372589</a>	Antithrombotic Therapy to Ameliorate Complications of COVID-19 ( ATTACC )	Canada	Y	N	Drug Repurposing	Heparin	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04273321">NCT04273321</a>	Efficacy and Safety of Corticosteroids in COVID-19	China	Y	N	Drug Repurposing	Methylprednisolone	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04474340">NCT04474340</a>	COVID-19 Convalescent Plasma Treatment in SARS-CoV-2 Infected Patients	Kuwait	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04403477">NCT04403477</a>	Convalescent Plasma Therapy in Severe COVID-19 Infection	Bangladesh	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04351490">NCT04351490</a>	Impact of Zinc and Vitamin D3 Supplementation on the Survival of Aged Patients Infected With COVID-19	France	Y	N	Drug Repurposing	Zinc, Vitamin D3	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04375735">NCT04375735</a>	London's Exogenous Surfactant Study for COVID19	United States	Y	N	Drug Repurposing	Bovine Lipid Extract Surfactant	Safety	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04353336">NCT04353336</a>	Efficacay of Chloroquine or Hydroxychloroquine in COVID-19 Treatment	Egypt	Y	N	Drug Repurposing	Chloroquine, Hydroxychloroquine	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04397796">NCT04397796</a>	Study of the Safety of Therapeutic Tx With Immunomodulatory MSC in Adults With COVID-19 Infection Requiring Mechanical Ventilation	United States	Y	N	Cell/Blood based	ND:Stem cells	Safety	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04399889">NCT04399889</a>	hCT-MSCs for COVID19 ARDS	United States	Y	N	Cell/Blood based	ND:MSC	Safety	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04331665">NCT04331665</a>	Study of the Efficacy and Safety of Ruxolitinib to Treat COVID-19 Pneumonia	Canada	N	N	Drug Repurposing	Ruxolitinib	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04362111">NCT04362111</a>	Early Identification and Treatment of Cytokine Storm Syndrome in Covid-19	United States	Y	N	Drug Repurposing	Anakinra	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04378920">NCT04378920</a>	A Study of Trans Crocetin in Patients With Acute Respiratory Distress Syndrome Due to COVID-19 Disease (LEAF-4L7520/4L6715)	France	N	N	Shelved drug or NME	LEAF-4L7520, LEAF-4L6715	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04318444">NCT04318444</a>	Hydroxychloroquine Post Exposure Prophylaxis for Coronavirus Disease (COVID-19)	United States	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04389671">NCT04389671</a>	The Safety and Preliminary Efficacy of Lucinactant in Adults With COVID-19	United States	N	N	Drug Repurposing	Lucinactant	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04395105">NCT04395105</a>	Dexamethasone for COVID-19 Related ARDS: a Multicenter, Randomized Clinical Trial	Argentina	Y	N	Drug Repurposing	Dexamethasone	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04402203">NCT04402203</a>	Study on Safety and Efficacy of Favipiravir (Favipira) for COVID-19 Patient in Selected Hospitals of Bangladesh	Bangladesh	Y	N	Drug Repurposing	Favipiravir	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04438837">NCT04438837</a>	Hydroxychloroquine Post-Exposure Prophylaxis for Coronavirus Disease (COVID-19) Among Health-Care Workers	Israel	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04467840">NCT04467840</a>	Opaganib, a Sphingosine Kinase-2 (SK2) Inhibitor in COVID-19 Pneumonia	United States	Y	N	Shelved drug or NME	Opaganib	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04402944">NCT04402944</a>	Pulmozyme to Improve COVID-19 ARDS Outcomes	United States	Y	N	Drug Repurposing	Dornase alfa	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04407390">NCT04407390</a>	Effects of Nicotinamide Riboside on the Clinical Outcome of Covid-19 in the Elderly	Denmark	Y	N	Shelved drug or NME	Nicotinamide Riboside	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04318015">NCT04318015</a>	Hydroxychloroquine Chemoprophylaxis in Healthcare Personnel in Contact With COVID-19 Patients (PHYDRA Trial)	Mexico	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04341038">NCT04341038</a>	Clinical Trial to Evaluate Methylprednisolone Pulses and Tacrolimus in Patients With COVID-19 Lung Injury	Spain	Y	N	Drug Repurposing	Methylprednisolone, Tacrolimus	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04381988">NCT04381988</a>	A Study of Hydroxychloroquine vs Placebo to Prevent COVID-19 Infection in Patients Receiving Radiotherapy	United States	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Other	
<a href="https://ClinicalTrials.gov/show/NCT04456361">NCT04456361</a>	Use of Mesenchymal Stem Cells in Acute Respiratory Distress Syndrome Caused by COVID-19	Mexico	N	N	Cell/Blood based	ND:Stem cells	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04330144">NCT04330144</a>	Hydroxychloroquine as Post Exposure Prophylaxis for SARS-CoV-2(HOPE Trial)	Korea, Republic of	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04392713">NCT04392713</a>	Efficacy of Ivermectin in COVID-19	Pakistan	Y	N	Drug Repurposing	Ivermectin	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04407689">NCT04407689</a>	InterLeukin-7 to Improve Clinical Outcomes in Lymphopenic pAtients With COVID-19 Infection FR BL Cohort	France	Y	N	Shelved drug or NME	CYT107	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04379076">NCT04379076</a>	InterLeukin-7 (CYT107) to Improve Clinical Outcomes in Lymphopenic pAtients With COVID-19 Infection UK Cohort	United Kingdom	Y	N	Shelved drug or NME	Interleukin-7 (CYT107)	Other	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04445311">NCT04445311</a>	Ivermectin in Treatment of COVID-19	Egypt	Y	N	Drug Repurposing	Ivermectin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04377997">NCT04377997</a>	Safety and Efficacy of Therapeutic Anticoagulation on Clinical Outcomes in Hospitalized Patients With COVID-19	United States	Y	N	Drug Repurposing	Enoxaparin	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04345848">NCT04345848</a>	Preventing COVID-19 Complications With Low- and High-dose Anticoagulation	Switzerland	Y	N	Drug Repurposing	Enoxaparin	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04335552">NCT04335552</a>	Pragmatic Factorial Trial of Hydroxychloroquine, Azithromycin, or Both for Treatment of Severe SARS-CoV-2 Infection	United States	Y	Y	Drug Repurposing	Hydroxychloroquine, Azithromycin	Efficacy - WHO scale	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04436458">NCT04436458</a>	Niclosamide In Moderate COVID-19	United States	Y	N	Drug Repurposing	Niclosamide	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04343963">NCT04343963</a>	Pyridostigmine in Severe SARS-CoV-2 Infection	Mexico	Y	N	Drug Repurposing	Pyridostigmine	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04374149">NCT04374149</a>	Therapeutic Plasma Exchange Alone or in Combination With Ruxolitinib in COVID-19 Associated CRS	United States	Y	N	Drug Repurposing, Other	Ruxolitinib, ND:Procedure	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04419610">NCT04419610</a>	RAS and Coagulopathy in COVID19	United Kingdom	Y	N	Shelved drug or NME	TRV027	Efficacy - Other efficacy	Other	
<a href="https://ClinicalTrials.gov/show/NCT04401475">NCT04401475</a>	A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of EB05 + SOC vs. Placebo + SOC in Adult Hospitalized Patients With Moderate to Severe COVID-19	United States	Y	N	Shelved drug or NME	EB05	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04390061">NCT04390061</a>	TOFAcitinib Plus Hydroxycloroquine vs Hydroxycloroquine in Patients With COVID-19 Interstitial Pneumonia	Italy	Y	N	Drug Repurposing	Tofacitinib	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04359329">NCT04359329</a>	Estrogen Patch for COVID-19 Symptoms	United States	Y	N	Drug Repurposing	Estrogen patch	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04422561">NCT04422561</a>	Prophylactic Ivermectin in COVID-19 Contacts	Egypt	N	N	Drug Repurposing	Ivermectin	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04403555">NCT04403555</a>	Ivermectin and Doxycycine in COVID-19 Treatment	Egypt	Y	N	Drug Repurposing	Doxycycline, Ivermectin	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04351295">NCT04351295</a>	Efficacy of Faviprevir in COVID-19 Treatment	Egypt	Y	N	Drug Repurposing	Favipiravir	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04401293">NCT04401293</a>	Full Dose Heparin Vs. Prophylactic Or Intermediate Dose Heparin in High Risk COVID-19 Patients	United States	Y	N	Drug Repurposing	Enoxaparin	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04387240">NCT04387240</a>	Evaluating the Efficacy of Artesunate in Adults With Mild Symptoms of COVID-19	Saudi Arabia	Y	N	Drug Repurposing	Artesunate	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04426201">NCT04426201</a>	InterLeukin-7 to Improve Clinical Outcomes in Lymphopenic pAtients With COVID-19 Infection ( ILIAD-7-US-O )	United States	Y	N	Shelved drug or NME	CYT107	Efficacy - Other efficacy	Other	
<a href="https://ClinicalTrials.gov/show/NCT04345406">NCT04345406</a>	Angiotensin Converting Enzyme Inhibitors in Treatment of Covid 19	Egypt	Y	N	Drug Repurposing	Captopril, Enalapril	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04388709">NCT04388709</a>	Interferon Lambda Therapy for COVID-19	United States	Y	N	Drug Repurposing	Peginterferon lambda-1a	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04433988">NCT04433988</a>	Efficacy of Pentoxifylline as Add on Therapy in COVID19 Patients	Egypt	Y	N	Drug Repurposing	Pentoxifylline	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04374019">NCT04374019</a>	Novel Agents for Treatment of High-risk COVID-19 Positive Patients	United States	Y	Y	Drug Repurposing	Hydroxychloroquine, Azithromycin, Ivermectin, Camostat, Artemisinin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04460443">NCT04460443</a>	Sofosbuvir With and Without Ribavirin in Treatment of COVID 19	Egypt	Y	Y	Drug Repurposing	Sofosbuvir, Ribavirin, Daclatasvir	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04363853">NCT04363853</a>	Tocilizumab Treatment in Patients With COVID-19	Mexico	N	N	Drug Repurposing	Tocilizumab	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04361032">NCT04361032</a>	Assessment of Efficacy and Safety of Tocilizumab Compared to DefeROxamine, Associated With Standards Treatments in COVID-19 (+) Patients Hospitalized In Intensive Care in Tunisia	Tunisia	Y	N	Drug Repurposing	Tocilizumab, Deferoxamine	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04424901">NCT04424901</a>	Trial of Open Label Dipyridamole- In Hospitalized Patients With COVID-19	United States	Y	N	Drug Repurposing	Dipyridamole	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04374552">NCT04374552</a>	Asymptomatic COVID-19 Trial	United States	Y	N	Drug Repurposing	Hydroxychloroquine, Azithromycin	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04408040">NCT04408040</a>	Use of Convalescent Plasma for COVID-19	United States	N	Y	Cell/Blood based	ND:Convalescent plasma	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04359901">NCT04359901</a>	Sarilumab for Patients With Moderate COVID-19 Disease	United States	Y	N	Drug Repurposing	Sarilumab	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04371107">NCT04371107</a>	Proactive Care of Ambulatory COVID19 Patients	France	Y	N	Drug Repurposing	Azithromycin	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04459247">NCT04459247</a>	Short Term, High Dose Vitamin D Supplementation for COVID-19	India	Y	N	Drug Repurposing	Vitamin D3	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04425915">NCT04425915</a>	Efficacy of Convalescent Plasma Therapy in Patients With COVID-19	India	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04351347">NCT04351347</a>	The Efficacy of Ivermectin and Nitazoxanide in COVID-19 Treatment	Egypt	Y	N	Drug Repurposing	Ivermectin, Nitazoxanide, Chloroquine	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04313127">NCT04313127</a>	Phase I Clinical Trial of a COVID-19 Vaccine in 18-60 Healthy Adults	China	N	N	Vaccine	ND:Vaccine	Safety	General population	
<a href="https://ClinicalTrials.gov/show/NCT04447534">NCT04447534</a>	Zinc With Chloroquine/Hydroxychloroquine in Treatment of COVID-19	Egypt	N	N	Drug Repurposing	Zinc	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04469491">NCT04469491</a>	Treatment of COVID-19 by Nebulization of Inteferon Beta 1b Efficiency and Safety Study	France	Y	N	Drug Repurposing	Interferon-1-beta	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04399746">NCT04399746</a>	Ivermectin-Azithromycin-Cholecalciferol (IvAzCol) Combination Therapy for COVID-19	Mexico	N	N	Drug Repurposing	Ivermectin, Azithromycin, Cholecalciferol	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04445467">NCT04445467</a>	An Adaptive Randomised Placebo Controlled Phase II Trial of Antivirals for COVID-19 Infection	United States	Y	N	Drug Repurposing	Favipiravir	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04393051">NCT04393051</a>	Baricitinib Compared to Standard Therapy in Patients With COVID-19	Italy	Y	N	Drug Repurposing	Baricitinib	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04391101">NCT04391101</a>	Convalescent Plasma for the Treatment of Severe SARS-CoV-2 (COVID-19)	Colombia	Y	N	Cell/Blood based	ND:Convalescent plasma	Safety	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04479163">NCT04479163</a>	Prevention of Severe Covid-19 in Infected Elderly by Early Administration of Convalescent Plasma With High-titers of Antibody Against SARS-CoV2	Cuba	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Oxygen parameters	Other	
<a href="https://ClinicalTrials.gov/show/NCT04472611">NCT04472611</a>	Colchicine/Statins for the Prevention of COVID-19 Complications (COLSTAT) Trial	United States	Y	N	Drug Repurposing	Colchicine, Rosuvastatin	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04343261">NCT04343261</a>	Convalescent Plasma in the Treatment of COVID 19	United States	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04356937">NCT04356937</a>	Efficacy of Tocilizumab on Patients With COVID-19	United States	Y	N	Drug Repurposing	Tocilizumab	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04475302">NCT04475302</a>	BCG Vaccine in Reducing Morbidity and Mortality in Elderly Individuals in COVID-19 Hotspots	India	Y	N	Drug Repurposing	BCG Vaccine	Efficacy - Mortality	Other	
<a href="https://ClinicalTrials.gov/show/NCT04344535">NCT04344535</a>	Convalescent Plasma vs. Standard Plasma for COVID-19	United States	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04371367">NCT04371367</a>	Avdoralimab an Anti-C5aR Antibody, in Patients With COVID-19 Severe Pneumonia ( FORCE )	France	Y	N	Shelved drug or NME	Avdoralimab	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04359862">NCT04359862</a>	Sedation With Sevoflurane Versus Propofol in Patients With Acute Respiratory Distress Syndrome Caused by COVID19 Infection	Spain	Y	N	Drug Repurposing	Sevoflurane	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04372082">NCT04372082</a>	Hydroxychloroquine or Diltiazem-Niclosamide for the Treatment of COVID-19	France	Y	Y	Drug Repurposing	Diltiazem, Niclosamide, Hydroxychloroquine	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04442048">NCT04442048</a>	Immunization With IMM-101 vs Observation for Prevention of Respiratory and Severe COVID-19 Related Infections in Cancer Patients at Increased Risk of Exposure	Canada	Y	N	Shelved drug or NME	IMM-101	Efficacy - Infection rate (prevention)	Other	
<a href="https://ClinicalTrials.gov/show/NCT04363502">NCT04363502</a>	Use of the Interleukin-6 Inhibitor Clazakizumab in Patients With Life-threatening COVID-19 Infection	United States	Y	N	Shelved drug or NME	Clazakizumab	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04392427">NCT04392427</a>	New Antiviral Drugs for Treatment of COVID-19	Egypt	Y	N	Drug Repurposing	Nitazoxanide, Ribavirin, Ivermectin	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04404361">NCT04404361</a>	PRE-VENT Study in Hospitalized Patients With Severe COVID-19 With or Without Cancer	United States	Y	N	Shelved drug or NME	Pacritinib	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04382924">NCT04382924</a>	Safety and Efficacy of NP-120 (Ifenprodil) for the Treatment of Hospitalized Patient With Confirmed COVID-19 Disease	Australia	Y	N	Shelved drug or NME	Ifenprodil	Efficacy - WHO scale	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04398290">NCT04398290</a>	iNOPulse for COVID-19	United States	Y	N	Drug Repurposing	Nitric oxide	Safety	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04445623">NCT04445623</a>	Prasugrel in Severe COVID-19 Pneumonia	Italy	Y	N	Drug Repurposing	Prasugrel	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04344548">NCT04344548</a>	Phase I / II Clinical Study of Immunotherapy Based on Adoptive Cell Transfer as a Therapeutic Alternative for Patients With COVID-19 in Colombia	Colombia	N	N	Cell/Blood based	ND:NK-cells	Safety	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04408183">NCT04408183</a>	GLS-1200Topical Nasal Spray to Prevent SARS-CoV-2 Infection (COVID-19) in Health Care Personnel	United States	Y	N	Shelved drug or NME	GLS-1200	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04482673">NCT04482673</a>	Vitamin D Supplementation in the Prevention and Mitigation of COVID-19 Infection	United States	Y	N	Drug Repurposing	Vitamin D3	Other	Other	
<a href="https://ClinicalTrials.gov/show/NCT04334460">NCT04334460</a>	Safety and Antiviral Activity of BLD-2660 in COVID-19 Hospitalized Subjects	United States	Y	N	Shelved drug or NME	BLD-2660	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04328012">NCT04328012</a>	COVID MED Trial - Comparison Of Therapeutics for Hospitalized Patients Infected With SARS-CoV-2	United States	Y	Y	Drug Repurposing	Lopinavir/ritonavir, Hydroxychloroquine, Losartan	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04445389">NCT04445389</a>	Safety and Immunogenicity Study of GX-19, a COVID-19 Preventive DNA Vaccine in Healthy Adults	Korea, Republic of	Y	N	Vaccine	GX-19	Safety	Other	
<a href="https://ClinicalTrials.gov/show/NCT04468009">NCT04468009</a>	Treatment of Critically Ill Patients With Covid-19 With Convalescent Plasma	Argentina	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04261517">NCT04261517</a>	Efficacy and Safety of Hydroxychloroquine for Treatment of COVID-19	China	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04405570">NCT04405570</a>	A Safety, Tolerability and Efficacy of EIDD-2801 to Eliminate Infectious Virus Detection in Persons With COVID-19	United States	Y	N	Shelved drug or NME	EIDD-2801	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04382950">NCT04382950</a>	Combination of Recombinant Bacterial ACE2 Receptors -Like Enzyme of B38-CAP and Isotretinoin Could be Promising COVID-19 Infection- and Lung Injury Preventing Drug Better Than Recombinant Human ACE2	Israel	Y	N	Drug Repurposing, Shelved drug or NME	rbACE2, Isotretinoin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04450004">NCT04450004</a>	Safety, Tolerability and Immunogenicinity of a Coronavirus-Like Particle COVID-19 Vaccine in Adults Aged 18-55 Years.	United States	Y	N	Vaccine	ND:Vaccine	Safety	Other	
<a href="https://ClinicalTrials.gov/show/NCT04366245">NCT04366245</a>	Clinical Trial to Evaluate the Efficacy of Treatment With Hyperimmune Plasma Obtained From Convalescent Antibodies of COVID-19 Infection	Spain	Y	N	Cell/Blood based	ND:Convalescent plasma	Safety	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04367831">NCT04367831</a>	Intermediate or Prophylactic-Dose Anticoagulation for Venous or Arterial Thromboembolism in Severe COVID-19	United States	Y	N	Drug Repurposing	Heparin, Enoxaparin/Lovenox	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04373824">NCT04373824</a>	Max Ivermectin- COVID 19 Study Versus Standard of Care Treatment for COVID 19 Cases. A Pilot Study	India	Y	N	Drug Repurposing	Ivermectin	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04319731">NCT04319731</a>	A Pilot Study of Human Amniotic Fluid for COVID19 Associated Respiratory Failure	United States	N	N	Cell/Blood based	ND:Amniotic fluid	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04493242">NCT04493242</a>	Extracellular Vesicle Infusion Therapy for Severe COVID-19	United States	Y	N	Shelved drug or NME	DB-001	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04385199">NCT04385199</a>	Convalescent Plasma for Patients With COVID-19	United States	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04366323">NCT04366323</a>	Clinical Trial to Assess the Safety and Efficacy of Intravenous Administration of Allogeneic Adult Mesenchymal Stem Cells of Expanded Adipose Tissue in Patients With Severe Pneumonia Due to COVID-19	Spain	Y	N	Cell/Blood based	ND:Stem cells	Safety	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04257656">NCT04257656</a>	A Trial of Remdesivir in Adults With Severe COVID-19	China	Y	N	Shelved drug or NME	Remdesivir	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04492514">NCT04492514</a>	Mavrilimumab to Reduce Progression of Acute Respiratory Failure in COVID-19 Pneumonia and Systemic Hyper-inflation	United States	Y	N	Shelved drug or NME	Mavrilimumab	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04477993">NCT04477993</a>	Ruxolitinib for Acute Respiratory Disorder Syndrome Due to COVID-19	Brazil	Y	N	Drug Repurposing	Ruxolitinib	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04338698">NCT04338698</a>	Hydroxychloroquine, Oseltamivir and Azithromycin for the Treatment of COVID-19 Infection: An RCT	Pakistan	Y	Y	Drug Repurposing	Hydroxychloroquine, Oseltamivir, Azithromycin	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04375397">NCT04375397</a>	Study of Oral Ibrutinib Capsules to Assess Respiratory Failure in Adult Participants With Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) and Pulmonary Injury	United States	Y	N	Drug Repurposing	Ibrutinib	Efficacy - Other efficacy	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04439045">NCT04439045</a>	Efficacy and Safety of VPM1002 in Reducing SARS-CoV-2 (COVID-19) Infection Rate and Severity	United States	Y	N	Vaccine	ND:VPM1002 vaccine	Efficacy - Infection rate (prevention)	Other	
<a href="https://ClinicalTrials.gov/show/NCT04463004">NCT04463004</a>	Mavrilimumab to Reduce Progression of Acute Respiratory Failure in COVID-19 Pneumonia and Systemic Hyper-inflammation	United States	Y	N	Shelved drug or NME	Mavrilimumab	Efficacy - Mortality	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04399980">NCT04399980</a>	Mavrilimumab to Reduce Progression of Acute Respiratory Failure in COVID-19 Pneumonia and Systemic Hyper-inflammation	United States	Y	N	Shelved drug or NME	Mavrilimumab	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04397510">NCT04397510</a>	Nebulized Heparin for the Treatment of COVID-19 Induced Lung Injury	United States	Y	N	Drug Repurposing	Heparin	Efficacy - Oxygen parameters	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04457609">NCT04457609</a>	Administration of Allogenic UC-MSCs as Adjuvant Therapy for Critically-Ill COVID-19 Patients	Indonesia	Y	N	Drug Repurposing, Cell/Blood based	Oseltamivir, Azithromycin, ND:Stem cells	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04470427">NCT04470427</a>	A Study to Evaluate Efficacy, Safety, and Immunogenicity of mRNA-1273 Vaccine in Adults Aged 18 Years and Older to Prevent COVID-19	United States	Y	N	Vaccine	mRNA-1273 vaccine	Efficacy - Infection rate (prevention)	General population	
<a href="https://ClinicalTrials.gov/show/NCT04364737">NCT04364737</a>	CONTAIN COVID-19: Convalescent Plasma to Limit COVID-19 Complications in Hospitalized Patients	United States	Y	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - WHO scale	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04405076">NCT04405076</a>	Dose-Confirmation Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of mRNA-1273 COVID-19 Vaccine in Adults Aged 18 Years and Older	United States	Y	N	Vaccine	ND:Vaccine	Safety	General population	
<a href="https://ClinicalTrials.gov/show/NCT04349631">NCT04349631</a>	A Clinical Trial to Determine the Safety and Efficacy of Hope Biosciences Autologous Mesenchymal Stem Cell Therapy (HB-adMSCs) to Provide Protection Against COVID-19	United States	N	N	Cell/Blood based	ND:Stem cells	Efficacy - Other efficacy	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04379271">NCT04379271</a>	A Study to Evaluate the Efficacy, Safety and Tolerability of IMU-838 as Addition to Investigator's Choice of Standard of Care Therapy, in Patients With Coronavirus Disease 19 (COVID-19)	United States	Y	N	Shelved drug or NME	IMU-838	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04414241">NCT04414241</a>	Hydroxychloroquine to Prevent SARS-CoV-2 Infection	Peru	Y	N	Drug Repurposing	Hydroxychloroquine	Efficacy - Infection rate (prevention)	General population	
<a href="https://ClinicalTrials.gov/show/NCT04345601">NCT04345601</a>	Mesenchymal Stromal Cells for the Treatment of SARS-CoV-2 Induced Acute Respiratory Failure (COVID-19 Disease)	United States	N	N	Cell/Blood based	ND:MSC	Safety	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04399356">NCT04399356</a>	Niclosamide for Mild to Moderate COVID-19	United States	Y	N	Drug Repurposing	Niclosamide	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04351191">NCT04351191</a>	PRophylaxis of Exposed COVID-19 Individuals With Mild Symptoms Using choloroquinE Compounds	Pakistan	Y	Y	Drug Repurposing	Hydroxychloroquine, Chloroquine	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04377334">NCT04377334</a>	Mesenchymal Stem Cells (MSCs) in Inflammation-Resolution Programs of Coronavirus Disease 2019 (COVID-19) Induced Acute Respiratory Distress Syndrome (ARDS)	Germany	Y	N	Cell/Blood based	ND:Stem cells	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://anzctr.org.au/ACTRN12620000557932.aspx">ACTRN12620000557932</a>	Therapies to prevent progression of COVID-19, including Hydroxychloroquine, Azithromycin, Zinc, Vitamin D, Vitamin B12 with or without Vitamin C, a multi-centre, international, randomized trial: The International ALLIANCE Study	Australia	Y	Y	Drug Repurposing	Hydroxychloroquine, Azithromycin, Zinc Citrate, Vitamin D3, Vitamin B12, Ascorbic acid	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://anzctr.org.au/ACTRN12620000788976.aspx">ACTRN12620000788976</a>	Safety and efficacy of intranasal delivery of BromAc   (Bromelain & Acetylcysteine) in swab positive SARS-CoV-2 patients     inactivating the COVID-19 virus by cleavage of the spike and other glycoproteins	Australia	N	N	Drug Repurposing, Other	N-acetylcysteine, Bromelain	Safety	Mild/Moderate Cases	
<a href="http://www.chictr.org.cn/showproj.aspx?proj=49918">ChiCTR2000030259</a>	Evaluation Danoprevir sodium tablets combined with ritonavir in the treatment of novel coronavirus infection (COVID-19): a randomized, open and controlled trial	China	Y	N	Drug Repurposing, Shelved drug or NME	Danoprevir, Ritonavir	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="http://www.drks.de/DRKS00022484">DRKS00022484</a>	Clinical pilot study on the effects of a hydrogen peroxide mouthrinse on the intraoral viral load of SARS-CoV-2 (COVID-19)	Germany	N	N	Drug Repurposing	Hydrogen peroxide	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://jrct.niph.go.jp/latest-detail/jRCT2071200023">JPRN-jRCT2071200023</a>	Evaluation of Nelfinavir for asymptomatic and mild COVID-19: A multicenter open-label, blinded outcome, randomized controlled trial - NFV trial for asymptomatic and mild COVID-19	Japan	Y	N	Drug Repurposing	Nelfinavir	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://jrct.niph.go.jp/latest-detail/jRCTs051200036">JPRN-jRCTs051200036</a>	Efficacy and safety of nintedanib on lung fibrosis in severe pneumonia induced by coronavirus disease 2019: Historical control study.	Japan	N	N	Drug Repurposing	Nintedanib	Efficacy - Mortality	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-002039-31/FI">2020-002039-31</a>	COVIDSTORM - study protocol COVID-19: Slavage TOcilizumab as a Rescue Measure	Finland	N	N	Drug Repurposing	Tocilizumab	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-002038-33/FI">2020-002038-33</a>	Controlled clinical trial of hydroxychloroquine in the treatment of adult patients with Covid-19 infection in a primary care setting	Finland	Y	N	Drug Repurposing	Hydoxychloroquine	Efficacy - Other efficacy	Mild/Moderate Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-002102-58/BE">2020-002102-58</a>	Mesenchymal stromal cell therapy for severe COVID-19 infection	Belgium	N	N	Cell/Blood based	ND:MSC	Safety	Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-002458-25/IT">2020-002458-25</a>	Randomized, controlled, open label, phase 2 clinical trial of Interferon-&szlig;-1a (IFN&szlig;-1a) in COVID-19 patients.	Italy	Y	N	Drug Repurposing	Interferon beta 1a	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-002322-85/SE">2020-002322-85</a>	KAND567 Versus Placebo in Subjects Hospitalized with COVID-19. A Phase II, Randomized, 2-Arm Parallel-Group, Double-blind Study to Evaluate Efficacy, Safety, Tolerability, and Pharmacokinetics.	Sweden	Y	N	Shelved drug or NME		Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-001483-28/BE">2020-001483-28</a>	A Randomized, Double-blind, Placebo-controlled Phase 1/2a Study to Evaluate the Safety, Reactogenicity, and Immunogenicity of Ad26COVS1 in Adults Aged 18 to 55 Years Inclusive and Adults Aged 65 Years and Older	Belgium	Y	N	Shelved drug or NME	ND: Ad26COVS1 vaccine	Safety	General population	
<a href="https://www.clinicaltrialsregister.eu/ctr-search/trial/2020-002574-27/FR">2020-002574-27</a>	A randomized, double-blind, placebo-controlled phase 2a and 2b study to evaluate the safety and efficacy of XAV-19 in patients with COVID-19 induced moderate pneumonia	France	Y	N	Shelved drug or NME	XAV-19	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04510233">NCT04510233</a>	Ivermectin Nasal Spray for COVID19 Patients	Egypt	Y	N	Drug Repurposing	Ivermectin	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04501796">NCT04501796</a>	A Trial of NT-I7 in COVID-19 (SPESELPIS)	United States	Y	N	Shelved drug or NME	NT-17	Safety	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04513158">NCT04513158</a>	Convalescent Plasma in the Early Treatment of High-Risk Patients With SARS-CoV-2 (COVID-19) Infection	United States	N	N	Cell/Blood based	ND:Convalescent plasma	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04514302">NCT04514302</a>	Safety and Efficacy of Anti-SARS-CoV-2 Equine Antibody Fragments (INOSARS) for Hospitalized Patients With COVID-19	Mexico	Y	Y	Shelved drug or NME	INOSARS	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04504240">NCT04504240</a>	Role of Famotidine in the Symptomatic Improvement of COVID-19 Patients	Bangladesh	Y	N	Drug Repurposing	Famotidine	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04500418">NCT04500418</a>	Charit  Trial of Cenicriviroc (CVC) Treatment for COVID-19 Patients	Germany	Y	N	Shelved drug or NME	Cenicriviroc	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04516746">NCT04516746</a>	Phase III Double-blind, Placebo-controlled Study of AZD1222 for the Prevention of COVID-19 in Adults	United States	Y	N	Vaccine	AZD1222	Efficacy - Infection rate (prevention)	General population	
<a href="https://ClinicalTrials.gov/show/NCT04333732">NCT04333732</a>	CROWN CORONATION: COVID-19 Research Outcomes Worldwide Network for CORONAvirus prevenTION	United States	Y	Y	Vaccine	MR Vaccine, MMRII Vaccine	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP), General population	
<a href="https://ClinicalTrials.gov/show/NCT04497948">NCT04497948</a>	Acalabrutinib Study With Best Supportive Care in Participants Hospitalized With COVID-19	United States	N	N	Drug Repurposing	Acalabrutinib	Other	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04513184">NCT04513184</a>	Randomized Clinical Trial of Intranasal Dexamethasone as an Adjuvant in Patients With COVID-19	Mexico	Y	N	Drug Repurposing	Dexamethasone	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04497298">NCT04497298</a>	Clinical Trial to Evaluate the Safety and Immunogenicitiy of the COVID-19 Vaccine	France	Y	Y	Vaccine	TMV-083 Vaccine	Safety	General population	
<a href="https://ClinicalTrials.gov/show/NCT04501978">NCT04501978</a>	Therapeutics for Inpatients With COVID-19	United States	Y	N	Drug Repurposing, Shelved drug or NME	LY3819253, Remdesivir	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04511819">NCT04511819</a>	Losmapimod Safety and Efficacy in COVID-19	United States	Y	N	Shelved drug or NME	Losmapimod	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04390594">NCT04390594</a>	Efficacy and Safety Evaluation of Treatment Regimens in Adult COVID-19 Patients in Senegal	Senegal	Y	N	Drug Repurposing	Nafamostat	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04501783">NCT04501783</a>	Study of Efficacy and Safety of TL-FVP-t vs. SOC in Patients With Mild to Moderate COVID-19	Russian Federation	Y	N	Drug Repurposing	Favipiravir	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04498325">NCT04498325</a>	Evaluating the Effect of NT-I7, a Long Acting Interleukin-7, to Increase Lymphocyte Counts and Enhance Immune Clearance of SARS-CoV-2 (COVID-19)	United States	Y	Y	Shelved drug or NME	NT-I7	Safety	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04513470">NCT04513470</a>	Allocetra-OTS in COVID-19	Israel	N	N	Cell/Blood based	ND:Allocetra-OTS	Safety	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04516954">NCT04516954</a>	Convalescent Plasma for COVID-19 Patients	Viet Nam	N	N	Cell/Blood based	ND:Convalescent plasma	Safety	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04498273">NCT04498273</a>	COVID-19 Positive Outpatient Thrombosis Prevention in Adults Aged 40-79	United States	Y	Y	Drug Repurposing	Aspirin, Apixaban	Efficacy - Other efficacy	Mild/Moderate Cases, Other	
<a href="https://ClinicalTrials.gov/show/NCT04504734">NCT04504734</a>	Bucillamine in Treatment of Patients With COVID-19	Canada	Y	N	Drug Repurposing	Bucillamine	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04497649">NCT04497649</a>	Sofosbuvir Containing Regimens in Treatment of COVID 19 Patients	Egypt	Y	N	Drug Repurposing	Ledipasvir, Ribavirin, Daclatasvir, Sofosbuvir	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04509999">NCT04509999</a>	Bicalutamide to Block TMPRSS2 in Males With COVID-19 Infection	United States	Y	N	Drug Repurposing	Bicalutamide	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases, Other	
<a href="https://ClinicalTrials.gov/show/NCT04505774">NCT04505774</a>	Anti-thrombotics for Adults Hospitalized With COVID-19	United States	Y	N	Drug Repurposing	Heparin	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04500132">NCT04500132</a>	To Evaluate Safety and Efficacy of EC-18 in COVID-19 Infection to Pneumonia	Korea, Republic of	Y	N	Shelved drug or NME	EC-18	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04498377">NCT04498377</a>	Study of F-652 (IL-22:IgG2 Fusion Protein) in Patients With Moderate to Severe COVID-19	China	Y	N	Shelved drug or NME	F-652	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04502472">NCT04502472</a>	Open-label Treatment of Severe Coronavirus Disease 2019 (COVID-19) With Convalescent Plasma	United States	N	N	Cell/Blood based	ND:Convelescent plasma	Efficacy - Clinical improvement (except WHO scale)	Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04501965">NCT04501965</a>	Phytomedicines Versus Hydroxychloroquine as an Add on Therapy to Azythromycin in Asymptomatic Covid-19 Patients	Guinea	Y	N	Drug Repurposing, Other	Hydroxychloroquine, Azithromycine, ND:Phytomedicine	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04502342">NCT04502342</a>	Add on to Azythromycine, Phytomedicine and/or Antimalarial Drug vs Hydroxychloroquine in Uncomplicated COVID-19 Patients	Guinea	Y	Y	Drug Repurposing, Other	Hydroxycloroquine, Azythromycine, Cospherunate, ND;Phytomedicine	Efficacy - Viral load	Mild/Moderate Cases	
<a href="https://ClinicalTrials.gov/show/NCT04501952">NCT04501952</a>	Study to Evaluate the Efficacy and Safety of Remdesivir (GS-5734 ) Treatment of Coronavirus Disease 2019 (COVID-19) in an Outpatient Setting	United States	Y	N	Shelved drug or NME	Remdesivir	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04510207">NCT04510207</a>	A Study to Evaluate The Efficacy, Safety and Immunogenicity of Inactivated SARS-CoV-2 Vaccines (Vero Cell) in Healthy Population Aged 18 Years Old and Above	United Arab Emirates	Y	N	Vaccine	ND:Vaccine	Efficacy - Infection rate (prevention)	General population, Other	
<a href="https://ClinicalTrials.gov/show/NCT04484493">NCT04484493</a>	Corticosteroid Nasal Spray in COVID-19 Anosmia	Egypt	Y	N	Drug Repurposing	Mometasone furoate	Other	Other	
<a href="https://ClinicalTrials.gov/show/NCT04497987">NCT04497987</a>	A Study of LY3819253 (LY-CoV555) in Preventing SARS-CoV-2 Infection and COVID-19 in Nursing Home Residents and Staff	United States	Y	N	Shelved drug or NME	LY3819253	Efficacy - Infection rate (prevention)	Exposed individuals (family members, HCP)	
<a href="https://ClinicalTrials.gov/show/NCT04511650">NCT04511650</a>	A Study to Evaluate the Safety and Efficacy of Razuprotafib, a Novel Tie 2 Activator, in Hospitalized Subjects With Moderate to Severe Coronavirus Disease 2019 (COVID-19)	United States	Y	N	Shelved drug or NME	Razuprotafib	Safety	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04512079">NCT04512079</a>	FREEDOM COVID-19 Anticoagulation Strategy	United States	Y	N	Drug Repurposing	Apixaban	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04497389">NCT04497389</a>	Safety and Feasibility of Amniotic Fluid as a Treatment for COVID-19 Patients	United States	Y	N	Cell/Blood based	ND:Amniotic Fluid	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04509973">NCT04509973</a>	Higher vs. Lower Doses of Dexamethasone for COVID-19 and Severe Hypoxia	Denmark	Y	N	Drug Repurposing	Dexamethasone	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04499313">NCT04499313</a>	Dexamethasone Vs Methylprednisolone for the Treatment of Patients With ARDS Caused by COVID-19	Bangladesh	Y	N	Drug Repurposing	Dexamethasone, Methylprednisolone	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04517188">NCT04517188</a>	Halodine Nasal Antiseptic in Patients With COVID-19	United States	N	N	Shelved drug or NME	Povidone-Iodine	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04498247">NCT04498247</a>	A Study to Assess Safety, Tolerability, and Immunogenicity of V591 (COVID-19 Vaccine) in Healthy Participants (V591-001)	United States	Y	N	Vaccine	ND:Vaccine	Safety	Other	
<a href="https://ClinicalTrials.gov/show/NCT04500067">NCT04500067</a>	Intravenous Immunoglobulin (IVIG, Bioven) Efficacy Assess for COVID-19 / SARS-CoV-2 Severe Pneumonia Complex Treatment	Ukraine	Y	N	Cell/Blood based	ND:Immunoglobulin	Efficacy - Clinical improvement (except WHO scale)	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04508023">NCT04508023</a>	A Study of Rivaroxaban to Reduce the Risk of Major Venous and Arterial Thrombotic Events, Hospitalization and Death in Medically Ill Outpatients With Acute, Symptomatic Coronavirus Disease 2019 (COVID-19) Infection	United States	Y	N	Drug Repurposing	Rivaroxaban	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04510194">NCT04510194</a>	MET-Covid Trial - METformin for Prevention and Outpatient Treatment of COVID-19	United States	Y	N	Drug Repurposing	Metformin	Efficacy - Mortality	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04510038">NCT04510038</a>	Colchicine vs Current Standard of Care in Hospitalized Patients With COVID-19 and Cardiac Injury	United States	Y	N	Drug Repurposing	Colchicine	Efficacy - Mortality	Other	
<a href="https://ClinicalTrials.gov/show/NCT04510402">NCT04510402</a>	Phase I/II Trial of Povidone-iodine (PVP-I) Nasal Swab For Preventing COVID-19 Spread in Healthy Subjects	United Kingdom	N	Y	Shelved drug or NME	Povidone-Iodine	Safety	General population, Other	
<a href="https://ClinicalTrials.gov/show/NCT04345419">NCT04345419</a>	Remdesivir vs Chloroquine in Covid 19	Egypt	Y	Y	Drug Repurposing	Chloroquine, Remdesivir	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04445220">NCT04445220</a>	A Study of Cell Therapy in COVID-19 Subjects With Acute Kidney Injury Who Are Receiving Renal Replacement Therapy	United States	Y	N	Shelved drug or NME	SBI-101	Safety	Other	
<a href="https://ClinicalTrials.gov/show/NCT04498936">NCT04498936</a>	Sofosbuvir/Ledipasvir and Nitazoxanide for Treatment of COVID-19	Egypt	Y	N	Drug Repurposing	Ledipasvir/sofosbuvir, Nitazoxanide	Efficacy - Viral load	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04517396">NCT04517396</a>	Fenofibrate Intervention as COVID-19 Therapy	United States	Y	N	Drug Repurposing	Fenofibrate	Efficacy - WHO scale	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04504032">NCT04504032</a>	A Randomized, Controlled, Phase 2b Trial to Evaluate Safety and Efficacy of Rivaroxaban	United States	Y	N	Drug Repurposing	Rivaroxaban	Safety	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04505592">NCT04505592</a>	Tenecteplase in Patients With COVID-19	United States	Y	N	Drug Repurposing	Tenecteplase	Efficacy - Oxygen parameters	Mild/Moderate Cases, Severe Cases	
<a href="https://ClinicalTrials.gov/show/NCT04516941">NCT04516941</a>	CorONa Virus edoxabaN ColchicinE (CONVINCE) COVID-19	Switzerland	Y	Y	Drug Repurposing	Colchicine, Edoxaban	Efficacy - Other efficacy	Mild/Moderate Cases, Severe Cases